Genetic dissection of lateral septal circuitry that controls stress-induced persistent anxiety states

控制压力引起的持续焦虑状态的外侧间隔电路的基因解剖

基本信息

  • 批准号:
    10748497
  • 负责人:
  • 金额:
    $ 8.56万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-03-01 至 2023-12-31
  • 项目状态:
    已结题

项目摘要

Project Summary We are investigating the neural circuits that control persistent elevations of defensive behaviors following uncontrollable stress. This has potential human health benefits relevant to the mission of the NIH. In particular, exposure to uncontrollable stress is thought to contribute to or directly trigger the onset of multiple psychiatric disorders for which existing therapies are inadequate. Improved treatments for such disorders will require an understanding of how stressful experiences normally engage specific neural circuits to increase anxiety and defensive behaviors, as well as how abormal engagement of these circuits leads to mental illness. Corticotropin releasing factor receptors (CRFR) control behavioral and physiological responses to stress and are implicated in trauma-related mental illnesses, but the neural circuit-level mechanisms by which they act have not been clearly defined. One critically important region is the lateral septum (LS), which is potently activated by uncontrollable stressors and regulates severity of stress-induced anxious states via the type 2 CRFR (CRFR2) in rodent models. Moreover, neuroimaging studies of patients with stress-related disorders have consistently detected abnormalities in the hippocampus, a structure that is strongly connected with the LS. However, the precise means by which stress induces persistent CRFR2-dependent changes in anxiety and defensive behaviors via specific LS circuits, and the potential roles of hippocampal inputs, have not been determined. Here, we focus on filling this gap in knowledge by addressing two fundamentally important issues concerning LS connectivity and function in the mouse, a model organism whose brain shares high structural and molecular similarity to the human brain. In Aim 1, we will determine how activity of CRFR2-expressing neurons in LS changes following a stressful experience, and how these changes are related to the severity of stress-induced anxious behavior. As particular patterns of neural activity may promote resilience or susceptibility to stress, this aim has the potential to inform new approaches to prevent or treat stress-related disorders. We will also determine how the CRFR2 receptor alters activity of LS neurons. This is important as efforts to treat stress-related mental illnesses by administering drugs that act on CRF receptors have shown some promise but have had limited success. An improved understanding of how CRF receptors control brain activity may therefore result in development of more effective therapies. In Aim 2, we will determine how a specific input from the hippocampus is connected to the LS, responds to threat, and influences anxiety and fear-related behaviors.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Thomas L. Schwarz其他文献

Discovery of small molecule pathway regulators by image 2 profile matching
通过图像 2 配置文件匹配发现小分子途径调节剂
  • DOI:
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
    M. Rohban;Ashley M. Fuller;Ceryl Tan;Jonathan T. Goldstein;Deepsing Syangtan;Madhura P. Nijsure;M. Rigby;Joshua R. Sacher;S. M. Corsello;Grace B. Peppler;Marta;Bogaczynska;Gabrielle E Ciotti;Ann DeVine;M. Doan;Jennifer P. Gale;Rik Derynck;T. Turbyville;J. Boerckel;Shantanu Singh;L. Kiessling;Thomas L. Schwarz;X. Varelas;Ran Kafri;T. S. Eisinger;Anne E Carpenter
  • 通讯作者:
    Anne E Carpenter

Thomas L. Schwarz的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Thomas L. Schwarz', 18)}}的其他基金

Kinetochore Protein Functions in Synaptogenesis
动粒蛋白在突触发生中的功能
  • 批准号:
    10891859
  • 财政年份:
    2023
  • 资助金额:
    $ 8.56万
  • 项目类别:
Genetic dissection of lateral septal circuitry that controls stress-induced persistent anxiety states
控制压力引起的持续焦虑状态的外侧间隔电路的基因解剖
  • 批准号:
    10542797
  • 财政年份:
    2019
  • 资助金额:
    $ 8.56万
  • 项目类别:
Kinetochore Protein Functions in Synaptogenesis
动粒蛋白在突触发生中的功能
  • 批准号:
    10248433
  • 财政年份:
    2019
  • 资助金额:
    $ 8.56万
  • 项目类别:
Kinetochore Protein Functions in Synaptogenesis
动粒蛋白在突触发生中的功能
  • 批准号:
    10017352
  • 财政年份:
    2019
  • 资助金额:
    $ 8.56万
  • 项目类别:
Axonal Transport of mRNA for Mitochondrial Proteins
线粒体蛋白 mRNA 的轴突运输
  • 批准号:
    10210451
  • 财政年份:
    2018
  • 资助金额:
    $ 8.56万
  • 项目类别:
Axonal Transport of mRNA for Mitochondrial Proteins
线粒体蛋白 mRNA 的轴突运输
  • 批准号:
    9921501
  • 财政年份:
    2018
  • 资助金额:
    $ 8.56万
  • 项目类别:
Axonal Transport of mRNA for Mitochondrial Proteins
线粒体蛋白 mRNA 的轴突运输
  • 批准号:
    10430133
  • 财政年份:
    2018
  • 资助金额:
    $ 8.56万
  • 项目类别:
Developmental Neurology
发育神经病学
  • 批准号:
    9385084
  • 财政年份:
    2017
  • 资助金额:
    $ 8.56万
  • 项目类别:
2016 Cell Biology of the Neuron Gordon Research Conference and Gordon Research Seminar
2016年神经元细胞生物学戈登研究会议暨戈登研究研讨会
  • 批准号:
    9193674
  • 财政年份:
    2016
  • 资助金额:
    $ 8.56万
  • 项目类别:
Developmental Neurology
发育神经病学
  • 批准号:
    9385080
  • 财政年份:
    2016
  • 资助金额:
    $ 8.56万
  • 项目类别:

相似海外基金

RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 8.56万
  • 项目类别:
    Standard Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 8.56万
  • 项目类别:
    Standard Grant
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 8.56万
  • 项目类别:
    Training Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 8.56万
  • 项目类别:
    Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 8.56万
  • 项目类别:
    Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 8.56万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 8.56万
  • 项目类别:
    Studentship
ERI: Developing a Trust-supporting Design Framework with Affect for Human-AI Collaboration
ERI:开发一个支持信任的设计框架,影响人类与人工智能的协作
  • 批准号:
    2301846
  • 财政年份:
    2023
  • 资助金额:
    $ 8.56万
  • 项目类别:
    Standard Grant
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 8.56万
  • 项目类别:
    Operating Grants
How motor impairments due to neurodegenerative diseases affect masticatory movements
神经退行性疾病引起的运动障碍如何影响咀嚼运动
  • 批准号:
    23K16076
  • 财政年份:
    2023
  • 资助金额:
    $ 8.56万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了