Developmental Neurology

发育神经病学

• 批准号: 9385084
• 负责人: Thomas L. Schwarz
• 金额: $ 1.49万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-02-15 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9385084
• 关键词: Development; Neurology

 DESCRIPTION (provided by applicant): The Developmental Neurology Training Program at Boston Children's Hospital is designed to produce trainees who are equipped for and deeply engaged in state-of-the-art research in developmental neuroscience from a detailed and mechanistic perspective, while also cognizant of the clinical importance of their field and the clinical challenges and opportunities today. We take advantage of the presence of an extraordinary community of basic neuroscientists at Children's Hospital and its affiliated institutions, embedded in a world-class clinical setting. We select outstanding candidates who will work in one of 30 mentor laboratories and engage in fundamental research into the mechanisms that guide the development of the nervous system. These highly interactive laboratories employ genetics, molecular biology, biochemistry, electrophysiology, anatomy and behavior and use systems ranging from Drosophila to mouse, rat, and human cells. Consequently, our trainees are exposed to the full breadth of the field and are prepared to make informed strategic decisions. It is a special feature of this training program that each trainee wil be paired with a clinician or clinician-scientist as a co-mentor with the goal of helping trainees o understand the relationship of basic research to health and disease. This co-mentoring relationship will take advantage of the hospital setting and augment the rich opportunities for learning about translational research. The goal of the program is not to distract from an intensive research experience in fundamental molecular mechanisms of neurodevelopment, but rather to inform the trainee of its context in human health. The research experience of the trainee is also enhanced by an unusually extensive mentoring relationship with the Director of the Training Program, Prof. Thomas Schwarz, who meets with and advises all the trainees to offer feedback and career guidance. The training experience is also supplemented by a wealth of career-guidance instruction, including presentations skills, job- seeking skills, information about diverse career options, and of course the responsible conduct of research. All of this is situated within an environment of extraordinary resources and intellectual life. We have recruited a racially and ethnically diverse faculty of mentors and are committed to enhancing the diversity of the community of neuroscientists through our Training Program. The program thus seeks to enhance the experience of trainees beyond the opportunity to work with superb scientists tackling essential questions. There are few challenges in neuroscience as great as understanding the processes that result in neurodevelopmental disorders and intellectual disabilities and there is a growing awareness that many affective disorders arise from errors in development. Without deeper mechanistic understanding of these processes, the clinical challenges will remain. Training the next generation for this task is imperative.

 描述（由应用程序提供）：波士顿儿童医院的发育神经病学培训计划旨在生产受训者，这些受训者从详细和机械的角度从事并深入研究了最先进的神经科学研究，同时也认识到其领域的临床重要性以及当今的临床挑战和机会。我们利用了一个非凡的基本神经科学家在儿童医院及其关联机构的存在，并嵌入了世界一流的临床环境中。我们选择将在30个精神实验室之一中工作的杰出候选人，并从事指导神经系统发展的机制的基本研究。这些高度互动的实验室员工遗传学，分子生物学，生物化学，电生理学，解剖学和行为以及从果蝇到小鼠，大鼠和人类细胞的使用系统。因此，我们的学员将面临整个领域的广度，并准备做出明智的战略决策。这是该培训计划的一个特殊特征，每个学员将与临床或临床科学家配对，以帮助受训者了解基础研究与健康和疾病的关系。这种联合关系将利用医院的环境，并增加学习翻译研究的丰富机会。该计划的目的不是要分散神经发育基本分子机制的密集研究经验，而是要告知受训者在人类健康方面的背景。与培训计划主任托马斯·施瓦茨（Thomas Schwarz）教授托马斯·施瓦茨（Thomas Schwarz）的主任托马斯·施瓦茨（Thomas Schwarz）的主任托马斯·施瓦茨（Thomas Schwarz）会见并建议所有受训人员提供反馈和职业指导，还通过与培训计划主任托马斯·施瓦茨（Thomas Schwarz）教授建立了广泛的心理关系，从而增强了学员的研究经验。培训经验还包括丰富的职业实习指导，包括演讲技巧，寻求工作的技能，有关潜水员职业选择的信息，当然还有负责任的研究。所有这些都位于非凡资源和知识生活的环境中。我们已经招募了一个大致和种族多样化的导师学院，并致力于通过我们的培训计划来增强神经科学家社区的多样性。因此，该计划试图增强学员的经验，超越与出色的科学家一起解决基本问题的机会。神经科学中的挑战很少，就像了解导致神经发育障碍和智力障碍的过程一样，并且越来越认识到许多人因发育错误影响了许多疾病。如果没有更深入的机械理解这些过程，将仍然存在临床挑战。训练下一代为此任务是必要的。