Developmental Neurology

 描述(由申请者提供)：波士顿儿童医院的发展神经学培训计划旨在培养从详细和机械的角度为发展神经科学配备和深入从事最先进研究的受训人员，同时也认识到他们所在领域的临床重要性以及当今的临床挑战和机遇。我们利用儿童医院及其附属机构的基础神经学家的非凡社区的存在，嵌入世界级的临床环境。我们挑选优秀的候选人，他们将在30个导师实验室之一工作，并从事指导神经系统发育的机制的基础研究。这些高度互动的实验室使用遗传学、分子生物学、生物化学、电生理学、解剖学和行为学，并使用从果蝇到小鼠、大鼠和人类细胞的各种系统。因此，我们的受训人员接触到了整个领域，并准备做出明智的战略决定。该培训计划的一个特点是，每个学员将与一名临床医生或临床医生-科学家配对，作为共同导师，目的是帮助学员了解基础研究与健康和疾病的关系。这种共同指导关系将利用医院环境，并增加学习翻译研究的丰富机会。该项目的目的不是为了分散对神经发育基本分子机制的密集研究经验的注意力，而是要让学员了解其对人类健康的背景。培训项目主任Thomas Schwarz教授与培训项目主任Thomas Schwarz教授之间异常广泛的指导关系也增强了学员的研究经验，后者会见并建议所有学员提供反馈和职业指导。培训经验还包括丰富的职业指导指导，包括陈述技能、求职技能、关于不同职业选择的信息，当然还有负责任的研究工作。所有这一切都位于一个拥有非凡资源和智力生活的环境中。我们招募了一支种族和民族多元化的导师队伍，并致力于通过我们的培训计划加强神经科学家社区的多样性。因此，该计划旨在增强受训者的经验，超越与优秀科学家合作解决基本问题的机会。在神经科学中，几乎没有什么挑战像理解导致神经发育障碍和智力残疾的过程那么大，人们越来越意识到，许多情感障碍是由发育错误引起的。如果对这些过程没有更深入的机制了解，临床挑战仍将存在。为这项任务培训下一代是当务之急。

 DESCRIPTION (provided by applicant): The Developmental Neurology Training Program at Boston Children's Hospital is designed to produce trainees who are equipped for and deeply engaged in state-of-the-art research in developmental neuroscience from a detailed and mechanistic perspective, while also cognizant of the clinical importance of their field and the clinical challenges and opportunities today. We take advantage of the presence of an extraordinary community of basic neuroscientists at Children's Hospital and its affiliated institutions, embedded in a world-class clinical setting. We select outstanding candidates who will work in one of 30 mentor laboratories and engage in fundamental research into the mechanisms that guide the development of the nervous system. These highly interactive laboratories employ genetics, molecular biology, biochemistry, electrophysiology, anatomy and behavior and use systems ranging from Drosophila to mouse, rat, and human cells. Consequently, our trainees are exposed to the full breadth of the field and are prepared to make informed strategic decisions. It is a special feature of this training program that each trainee wil be paired with a clinician or clinician-scientist as a co-mentor with the goal of helping trainees o understand the relationship of basic research to health and disease. This co-mentoring relationship will take advantage of the hospital setting and augment the rich opportunities for learning about translational research. The goal of the program is not to distract from an intensive research experience in fundamental molecular mechanisms of neurodevelopment, but rather to inform the trainee of its context in human health. The research experience of the trainee is also enhanced by an unusually extensive mentoring relationship with the Director of the Training Program, Prof. Thomas Schwarz, who meets with and advises all the trainees to offer feedback and career guidance. The training experience is also supplemented by a wealth of career-guidance instruction, including presentations skills, job- seeking skills, information about diverse career options, and of course the responsible conduct of research. All of this is situated within an environment of extraordinary resources and intellectual life. We have recruited a racially and ethnically diverse faculty of mentors and are committed to enhancing the diversity of the community of neuroscientists through our Training Program. The program thus seeks to enhance the experience of trainees beyond the opportunity to work with superb scientists tackling essential questions. There are few challenges in neuroscience as great as understanding the processes that result in neurodevelopmental disorders and intellectual disabilities and there is a growing awareness that many affective disorders arise from errors in development. Without deeper mechanistic understanding of these processes, the clinical challenges will remain. Training the next generation for this task is imperative.