Boston University/Lata Medical Research Foundation Global Network for Women's Children's Health Research Unit

波士顿大学/拉塔医学研究基金会全球妇女儿童健康网络研究单位

• 批准号: 10747708
• 负责人: Patricia L Hibberd
• 金额: $ 62.27万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-03 至 2030-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10747708
• 关键词: 3 year old; Address; Age; Agreement; Arabs; Area; Azithromycin; Boston; Caring; Cesarean section; Cessation of life; Child; Child Health; Childhood; Clinical; Clinical Trials; Collaborations; Communicable Diseases; Country; Devices; Disabled Persons; Discipline of obstetrics; Disparity; Environmental Exposure; Exposure to; Faculty; Foundations; Goals; Government; Growth and Development function; Haplotypes; Health; Household Air Pollution; India; Infant Malnutrition; Infant Mortality; Infrastructure; Institution; Intervention; Lactation; Lead; Leadership; Live Birth; Medical; Medical Research; Mentors; Metagenomics; Mobile Health Application; Morbidity - disease rate; Multi-Institutional Clinical Trial; National Institute of Child Health and Human Development; Neonatal; Neonatal Mortality; Neonatology; Newborn Infant; Observational Study; Outcome; Patients; Pediatric Research; Pediatrics; Population; Population Heterogeneity; Populations at Risk; Pregnancy; Pregnant Women; Productivity; Protocols documentation; Publications; Rationalization; Reproducibility; Research; Research Design; Research Infrastructure; Research Personnel; Resource-limited setting; Risk; Role; Schools; Science; Sickle Cell Anemia; Site; Slum; Socioeconomic Status; Strategic Planning; Students; Sustainable Development; Testing; Time; Tribes; Underserved Population; United Nations; Universities; Variant; Woman; adolescent health; adverse outcome; azithromycin resistance; clinical research site; cost effective; data access; data sharing; design; early childhood; fetal; genome sequencing; global health; improved; indexing; low and middle-income countries; maternal depression; maternal risk; medical schools; microbiome; mortality; novel; patient engagement; point-of-care diagnostics; pregnant; prepregnancy; public health intervention; public health research; recruit; reproductive; retention rate; therapeutically effective; whole genome

PROJECT SUMMARY Although there have been improvements in the under age five mortality rate (U5MR) and neonatal mortality rate (NMR) in Indian children, the burden of death in this population is still one live births to deaths. To achieve the United Nations Sustainable Development Goals for the U5MR and NMR rate, there is still an urgent need for improvement in pre-pregnancy through childhood care in India and globally. The overarching goal of Boston University (BU) and Lata Medical Research Foundation's (LMRF) Global Network (GN) for Women's and Children's Health Research Unit (RU) is to continue to collaborate with other GN RUs on research to improve health outcomes for women and children in low- and lower middle-income countries (LMIC). We have had a GN RU in Nagpur, India continuously since 2008. Our RU is in the eastern part of the State of Maharashtra (center of India) where NMR and infant mortality rates are higher than the overall rates in the state and many other parts of India. Our RU involves a partnership between multiple Schools and Departments (particularly Global Health, Obstetrics, Pediatrics, and Infectious Diseases) at Boston University and the academic medical institutional consortium led by the LMRF in Nagpur, that provides clinical, research expertise and infrastructure support. Since 2008, our RU has been successfully implementing studies, by patient and public involvement and engagement strategy, that exemplify Global Network's goals to conduct high-impact clinical trials and observational studies of sustainable, cost-effective health interventions and their implementation in women and children in LMICs, and building sustainable professional capacity and infrastructure for infectious diseases (maternal and pediatric), obstetric, neonatal and pediatric research. In the current cycle of the GN, we have participated in all common protocols, and have maintained high recruitment and retention rates. We have led 5 research initiatives, including developing a new socioeconomic status index, and studying the risk of maternal, fetal and neonatal adverse outcomes associated with exposure to household air pollution, Caesarian Section delivery and Maternal Depression. We have also had a leadership role in the Azithromycin trial sub-study on risk of acquiring Azithromycin resistance using novel microbiome, metagenomics and whole genome sequencing approaches, which required helping develop lab capacity in several GN sites. We have jointly and successfully mentored 20 junior faculty, fellows and students who have led site specific and GN wide publications. continue growth and development of the Nagpur RU, advance the research network in the region, and sustain the research infrastructure for the design and conduct of public health research in the Nagpur academic institutions; strengthen research focused on the leading causes of morbidity and mortality in pregnancy and early childhood in the GN and in the Nagpur area by public and patient engagement; and continue to identify and address gaps in maternal and child research.

项目总结

项目成果

Assessing the Respiratory Effects of Air Pollution from Biomass Cookstoves on Pregnant Women in Rural India.

• DOI: 10.3390/ijerph18010183
• 发表时间: 2020-12-29
• 期刊: International journal of environmental research and public health
• 作者: Parikh R;Rao SR;Kukde R;O'Connor GT;Patel A;Hibberd PL
• 通讯作者: Hibberd PL

Detection and risk stratification of women at high risk of preterm birth in rural communities near Nagpur, India.

• DOI: 10.1186/s12884-017-1504-4
• 发表时间: 2017-09-19
• 期刊: BMC pregnancy and childbirth
• 影响因子: 3.1
• 作者: Patel A;Prakash AA;Pusdekar YV;Kulkarni H;Hibberd P
• 通讯作者: Hibberd P

Gender variations in neonatal and early infant mortality in India and Pakistan: a secondary analysis from the Global Network Maternal Newborn Health Registry.

印度和巴基斯坦新生儿和婴儿早期死亡率的性别差异：全球新生儿卫生注册表的二次分析。

• DOI: 10.1186/s12978-020-01028-0
• 发表时间: 2020-12-17
• 期刊: Reproductive health
• 影响因子: 3.4
• 作者: Aghai ZH;Goudar SS;Patel A;Saleem S;Dhaded SM;Kavi A;Lalakia P;Naqvi F;Hibberd PL;McClure EM;Nolen TL;Iyer P;Goldenberg RL;Derman RJ
• 通讯作者: Derman RJ

Early Identification of Preterm Neonates at Birth With a Tablet App for the Simplified Gestational Age Score (T-SGAS) When Ultrasound Gestational Age Dating Is Unavailable: Protocol for a Validation Study.

当超声孕龄测定不可用时，使用平板电脑应用程序进行简化孕龄评分 (T-SGAS) 早期识别早产新生儿：验证研究方案。

• DOI: 10.2196/11913
• 发表时间: 2019
• 期刊: JMIR research protocols
• 影响因子: 1.7
• 作者: Patel,ArchanaB;Kurhe,Kunal;Prakash,Amber;Bhargav,Savita;Parepalli,Suchita;Fogleman,ElizabethV;Moore,JanetL;Wallace,DennisD;Kulkarni,Hemant;Hibberd,PatriciaL
• 通讯作者: Hibberd,PatriciaL

What Helping Babies Breathe knowledge and skills are formidable for healthcare workers?

什么帮助婴儿呼吸知识和技能对于医护人员来说是可强大的？

• DOI: 10.3389/fped.2022.891266
• 发表时间: 2022
• 期刊: FRONTIERS IN PEDIATRICS
• 影响因子: 2.6
• 作者: Patel, Archana B. B.;Bang, Akash;Kurhe, Kunal;Bhargav, Savita;Hibberd, Patricia L. L.
• 通讯作者: Hibberd, Patricia L. L.