A Pragmatic Clinical Trial of MyPEEPS Mobile to Improve HIV prevention Behaviors in Diverse Adolescent MSM

项目摘要 男男性行为者（MSM）比世界上任何其他人口群体都承受着更大的艾滋病毒/艾滋病负担。 美国，仅占人口的2%，但艾滋病毒/艾滋病感染者占56%。 虽然大部分 据报道，年轻男男性行为者（YMSM）的艾滋病毒感染率有所上升，特别是在种族和民族之间 少数群体，并与高风险的性行为，仍然缺乏证据为基础的艾滋病毒 对YMSM的预防干预措施-没有一项针对种族/族裔多样化的YMSM。为了解决这个 需要，我们的研究，响应RFA-MD-15-012，利用移动的技术和MyPEEPS，现有的 理论驱动，多种族，群体水平，以证据为基础的干预，为不同的YMSM。MyPEEPS是一个 由我们建议的调查小组成员开发的手动课程，包括6个模块 注重关键的中间社会和个人因素，包括知识（例如，正确的使用方法 安全套）、安全性行为的自我效能、人际沟通技巧和行为技巧。MyPEEPS是一个 这是文献中唯一关注不同青少年MSM的艾滋病预防干预措施。长期 面对面的、群体层面的行为干预措施（如MyPEEPS）的可持续性一直存在问题 在高危人群中传播，特别是在年轻的种族和少数民族群体中传播。在 为了应对这一挑战，我们建议将MyPEEPS从一个面对面的、基于小组的课程转化为 一个移动的、响应驱动的基于Web的平台，可通过智能手机或其他支持Web的设备访问， 为不同YMSM增加可访问性和可扩展性。移动的电话在日常生活中无处不在的特性， 特别是在13-18奥尔兹的青少年中，创造了以便携式形式进行卫生干预的机会， 增强隐私。使用参与式的方法，我们的研究将纳入以用户为中心的设计， 将MyPEEPS干预翻译到移动的平台上。MyPEEPS移动的将在RCT中进行测试 13-18岁的不同种族和民族艾滋病毒阴性或身份不明的青年男男性行为者， 不同的地点：伯明翰、芝加哥、纽约市和西雅图，从而增加了 调查结果。所提出的MyPEEPS移动的干预是一种新型的证据驱动的干预，使用移动的 提供专门为高危YMSM开发的艾滋病毒预防信息的技术。才是最 第一批测试现有艾滋病毒预防干预措施的扩大版移动的版本的有效性的研究 最初是为YMSM的不同群体开发、设计和试验的。研究团队拥有独特的 经验和专业知识来进行这项重要的工作，并进行了重要的初步工作， 到项目目标。如果有效，公共卫生影响是巨大的，因为干预措施已经在移动的 这是一种非常适合广泛传播的格式。

PROJECT SUMMARY Men who have sex with men (MSM) bear a greater burden of HIV/AIDS than any other population group in the US, comprising only 2% of the population but 56% of individuals living with HIV/AIDS. Although much of the increased incidence in HIV has been reported among young MSM (YMSM), especially among racial and ethnic minority groups, and is linked to high-risk sexual behavior, there remains a dearth of evidence-based HIV prevention interventions for YMSM – and none that address racially/ethnically diverse YMSM. To address this need, our study, in response to RFA-MD-15-012, leverages mobile technology and MyPEEPS, an existing theory-driven, multi-ethnic, group-level, evidence-based intervention for diverse YMSM. MyPEEPS is a manualized curriculum, developed by members of our proposed Investigative team, comprised of 6 modules focusing on key intermediate social and personal factors, including knowledge (e.g., correct way to use a condom), self-efficacy for safer sex, interpersonal communication skills and behavioral skills. MyPEEPS is one of the only HIV prevention interventions in the literature that focuses on diverse adolescent MSM. Long-term sustainability of face-to face, group-level behavioral interventions, such as MyPEEPS, have been problematic for dissemination in at-risk populations, particularly among young racial and ethnic minority groups. In response to this challenge, we propose to translate MyPEEPS from a face-to-face, group-based curriculum to a mobile, responsive-driven web-based platform, accessible by smartphone or other web-enabled devices, to increase accessibility and scalability for diverse YMSM. The ubiquitous nature of mobile phones in daily life, especially among 13-18 year olds, has created opportunities for health interventions in a portable format with enhanced privacy. Using a participatory approach, our study will incorporate user-centered design in the translation of the MyPEEPS intervention onto a mobile platform. MyPEEPS Mobile will be tested in an RCT with racially and ethnically diverse HIV-negative or unknown status YMSM aged 13-18 at four geographically diverse sites: Birmingham, Chicago, New York City, and Seattle, allowing for increased generalizability of findings. The proposed MyPEEPS Mobile intervention is a novel and evidence-driven intervention using mobile technology to deliver HIV prevention information specifically developed for at-risk YMSM. This will be the one of the first studies to test the efficacy of a scaled-up, mobile version of an existing HIV prevention intervention originally developed for, designed by, and piloted for, a diverse group of YMSM. The research team has unique experience and expertise to conduct this important work and has conducted significant preliminary work related to the project goals. If efficacious, the public health impact is large, as the intervention will already be in mobile format which is well-suited for widespread dissemination.