Point of Care Diagnostic test for Molecular Subtyping of Breast Cancer (PoCBreCa Study)
Point of Care Diagnostic test for Molecular Subtyping of Breast Cancer (PoCBreCa Study)
批准号:
10348749
负责人:
Clement Adebayo Adebamowo
金额:
$17.67万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
未结题
起止时间:
2021-02-10 至 2025-01-31
关键词:
AddressAfricanAreaBaltimoreBioethicsBiological AssayBiological MarkersBreast Cancer PatientBreast Cancer PreventionBreast Cancer TreatmentCellular PhoneChemistryClinical ResearchConflict (Psychology)Continuity of Patient CareCountryDiagnosisDiagnostic Reagent KitsDiseaseEpidemiologic FactorsEpidemiologyEpigenetic ProcessEvaluationFeasibility StudiesFundingGeneticGenetic VariationGenomicsGoldHormone ReceptorHuman ResourcesImmunohistochemistryIn VitroIncidenceInfrastructureInvestigationInvestmentsKnowledgeLaboratoriesLogisticsMalignant NeoplasmsMammary NeoplasmsMarylandMethodologyMethodsMiniaturizationMolecular DiagnosisMolecular Diagnostic TestingMolecular EpidemiologyNanotechnologyNew YorkNigeriaOutcomePatternPhasePrognosisResearchResearch PersonnelResourcesRiskSamplingStandardizationSystemTechnologyTissue MicroarrayTissuesTrainingTraining and InfrastructureUnited StatesUniversitiesValidationWomanWorkanticancer researchbasecancer clinical trialchemotherapycostcost effectiveempoweredepidemiology studyepigenetic variationhormone therapyimprovedinnovationlow and middle-income countriesmalignant breast neoplasmmedical schoolsmolecular subtypesnew technologynovelnovel strategiespatient oriented researchphotonicspilot testpoint of carepoint-of-care diagnosticspre-clinicalprecision medicinepredicting responseprognosticationreceptorresponsesample archiveside effecttargeted treatmenttreatment researchtreatment responsetrend
中文摘要
乳腺癌分子分型的护理点诊断试验(PoCBreCa)研究
英文摘要
Point of Care Diagnostic test for Molecular Subtyping of Breast Cancer (PoCBreCa) Study
Project Summary
The incidence of breast cancer in low and middle-income countries (LMIC) is rising rapidly. Despite this,
very little is known about the epidemiology of molecular subtypes of breast cancer in these countries because of
lack of facilities, resources and personnel for immunohistochemistry (IHC), the current gold standard for
molecular subtyping of breast cancer. Innovative strategies that combine nanotechnology, photonics,
miniaturization and cell phone networks to develop new technologies and kits can overcome these limitations
and increase availability of molecular subtyping of breast cancer in LMIC.
Increased availability of molecular subtyping will enable epidemiological research into the determinants
and secular trend in the incidence of molecular subtypes of breast cancer in LMIC where previous studies have
yielded conflicting results. It will also empower clinicians in their choice of breast cancer treatment, prediction of
response and prognosis. The kits that we propose to develop in this project will generate quantitative results
which will open new research and treatment opportunities for precision medicine based on quantitative levels of
hormone receptors, its determinants and associations with germline and somatic, genetic and epigenetic
variations.
In this project, researchers at University of Maryland School of Medicine, Baltimore and Cornell University
in the United States, and Center for Bioethics and Research, and the University of Ibadan in Nigeria work
together to develop and pilot-test a point of care diagnostic kit for molecular subtyping of breast tumors and
compare it to IHC in order to overcome current challenges and open new opportunities for breast cancer
research.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Catalyzing Cancer Research among Urban Underrepresented Minority Youths and Teachers (CATALYST)
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批准号:10712869
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项目类别:
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资助金额:$38.88万
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财政年份:2023
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负责人:Clement Adebayo Adebamowo
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依托单位:
Baltimore CASCADE Study Site (BaCSS Project)
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批准号:10757186
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项目类别:
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资助金额:$30.9万
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财政年份:2023
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负责人:Clement Adebayo Adebamowo
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依托单位:
Scaling Up Research Ethics and Research Integrity (SURER) Project
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批准号:10593154
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项目类别:
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资助金额:$24.57万
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财政年份:2022
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负责人:Clement Adebayo Adebamowo
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依托单位:
Scaling Up Research Ethics and Research Integrity (SURER) Project
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批准号:10418132
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项目类别:
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资助金额:$24.95万
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财政年份:2022
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负责人:Clement Adebayo Adebamowo
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依托单位:
Bridging Gaps in the ELSI of Data Science Health Research in Nigeria (BridgELSI)
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批准号:10308577
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项目类别:
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资助金额:$40.0万
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财政年份:2021
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负责人:Clement Adebayo Adebamowo
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依托单位:
Eastern Nigeria Research Ethics Training (ENRICH) Program
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批准号:10374168
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项目类别:
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资助金额:$24.13万
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财政年份:2021
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负责人:Clement Adebayo Adebamowo
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依托单位:
Eastern Nigeria Research Ethics Training (ENRICH) Program
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批准号:10593101
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项目类别:
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资助金额:$24.13万
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财政年份:2021
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负责人:Clement Adebayo Adebamowo
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依托单位:
Bridging Gaps in the ELSI of Data Science Health Research in Nigeria (BridgELSI)
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批准号:10687098
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项目类别:
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资助金额:$40.0万
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财政年份:2021
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负责人:Clement Adebayo Adebamowo
-
依托单位:
Bridging Gaps in the ELSI of Data Science Health Research in Nigeria (BridgELSI)
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批准号:10491280
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项目类别:
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资助金额:$40.0万
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财政年份:2021
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负责人:Clement Adebayo Adebamowo
-
依托单位:
Eastern Nigeria Research Ethics Training (ENRICH) Program
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批准号:10228965
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项目类别:
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资助金额:$24.51万
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财政年份:2021
-
负责人:Clement Adebayo Adebamowo
-
依托单位:
Eastern Nigeria Research Ethics Training (ENRICH) Program
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批准号:10891919
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项目类别:
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资助金额:$18.36万
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财政年份:2021
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负责人:Clement Adebayo Adebamowo
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依托单位:
Entrenching Training and Capacity in Research Ethics in Nigeria (ENTRENCH) Program
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批准号:10170451
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项目类别:
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资助金额:$23.52万
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财政年份:2017
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负责人:Clement Adebayo Adebamowo
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依托单位:
AFRICAN FEMALE BREAST CANCER EPIDERMIOLOGY (AFBRECANE) STUDY
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批准号:10206220
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项目类别:
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资助金额:$23.82万
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财政年份:2017
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负责人:Clement Adebayo Adebamowo
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依托单位:
AFRICAN FEMALE BREAST CANCER EPIDERMIOLOGY (AFBRECANE) STUDY
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批准号:10409860
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项目类别:
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资助金额:$23.81万
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财政年份:2017
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负责人:Clement Adebayo Adebamowo
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依托单位:
AFRICAN FEMALE BREAST CANCER EPIDERMIOLOGY (AFBRECANE) STUDY
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批准号:9386289
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项目类别:
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资助金额:$24.87万
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财政年份:2017
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负责人:Clement Adebayo Adebamowo
-
依托单位:
AFRICAN FEMALE BREAST CANCER EPIDERMIOLOGY (AFBRECANE) STUDY
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批准号:10000207
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项目类别:
-
资助金额:$24.1万
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财政年份:2017
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负责人:Clement Adebayo Adebamowo
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依托单位:
Indigenous linguistic and cultural concepts of heritability and comprehension of
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批准号:9118282
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项目类别:
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资助金额:$9.65万
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财政年份:2014
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负责人:Clement Adebayo Adebamowo
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依托单位:
Indigenous linguistic and cultural concepts of heritability and comprehension of
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批准号:8680594
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项目类别:
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资助金额:$9.65万
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财政年份:2014
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负责人:Clement Adebayo Adebamowo
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依托单位:
African Collaborative Center for Microbiome and Genomics Research (ACCME)
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批准号:8576226
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项目类别:
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资助金额:$116.29万
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财政年份:2013
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负责人:Clement Adebayo Adebamowo
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依托单位:
African Collaborative Center for Microbiome and Genomics Research (ACCME)
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批准号:8913705
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项目类别:
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资助金额:$96.5万
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财政年份:2013
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负责人:Clement Adebayo Adebamowo
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依托单位:
海外基金