Advancing the science on recovery community centers to support persons treated with medications for opioid use disorder

推进康复社区中心的科学，以支持接受阿片类药物使用障碍药物治疗的人

• 批准号: 10754705
• 负责人: Bettina B. Hoeppner
• 金额: $ 11.37万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10754705
• 关键词: Advanced Development; Aphorisms; Capital; Chronic; Clinical; Communities; Contracts; Data; Disease remission; Education; Effectiveness; Employment; Formulation; Fostering; Funding; Goals; Growth; Health; Heart; Housing; Human Resources; Individual; Investigation; Investments; Life; Life Expectancy; Massachusetts; Narcotics Anonymous; Occupations; Outcome; Paper; Participant; Patients; Persons; Pharmaceutical Preparations; Pilot Projects; Play; Probability; Psychology; Public Health; Quality of life; Reader; Recovery; Recovery Support; Registries; Relapse; Reporting; Research; Research Infrastructure; Research Institute; Resources; Role; Science; Scientist; Series; Services; Slide; Social Network; Stress; Structure; Substance Use Disorder; Sum; Training; Twitter; United States National Institutes of Health; United States Substance Abuse and Mental Health Services Administration; Video Recording; addiction; biobehavior; community center; cost effectiveness; design; effectiveness research; efficacy research; experience; interest; marginalization; medication for opioid use disorder; meetings; opioid epidemic; opioid overdose; opioid use disorder; overdose death; person centered; prognostic; public health emergency; recovery services; repository; research study; symposium; tool; web site

PROJECT SUMMARY / ABSTRACT The opioid crisis has caused a national decline in average U.S. life-expectancy necessitating a declaration of a federal public health emergency. Evidence indicates that OUD is a chronic health condition best managed with long-term use of medications (MOUD). While MOUD save lives, reduce related harms, and enhance the likelihood of remission, compared to other substance use disorders, individuals suffering from OUD tend to be more in need of additional services, feel more isolated and marginalized, have fewer available recovery assets (e.g., jobs, safe housing) and report lower quality of life. These continued deficits increase biobehavioral stress and prognostic pessimism and, in turn, the odds of treatment discontinuation and subsequent relapse. There is a need for additional recovery support services (RSS) to help build positive social networks and to increase education, training, employment, and housing opportunities (collectively known as “recovery capital”) to enhance functioning and quality of life. Recovery Community Centers (RCCs) are emergent national entities designed specifically to help provide this growth in recovery capital and enhance remission and quality of life. Preliminary evidence indicates RCCs play a particularly valuable role for those with OUD, but despite their strong conceptual basis and rapid largescale investment in their growth, little is known from a systematic research standpoint about their clinical and public health utility and cost-effectiveness. To advance the development of efficacy and effectiveness research on RCCs for persons who were or who are being maintained on medications for the treatment of OUD (P-MOUD), we propose to orchestrate activities on a national level to engage multiple stakeholders and produce actionable deliverables. This proposal draws and builds upon numerous professional and academic resources and experiences, including the existence of our already established recovery dissemination platform (i.e., the Recovery Research Institute (RRI); 6,000 Bulletin readers, 37,000 Twitter followers, 24,000 website visitors per month), which due to its reputation and experience has been contracted by SAMHSA to first sum up the evidence on recovery support services and then to facilitate the first multi- stakeholder discussion on a national level to advance the science of RSS. In the spirit of the patient maxim, “nothing about us without us”, we have formulated a plan of action that engages and involves key support- receiving stakeholders in multiple aspects of our network plan. Five types of activities are proposed (i.e., monthly seminar series, pilot funding, symposium presentations at national conferences, advisory board meetings with RCC staff and attendees, hands-on support to RCC personnel to track and analyze organizational data), each of which will result in concrete deliverables. In so doing, the RRI will become a known hub for the science on recovery support via RCCs, and will attract, collect and disseminate ancillary products that support the building of a cumulative RCC science that can explicate the role of RCCs in providing support specifically for P-MOUD.

项目摘要 /摘要 阿片类药物危机已导致美国平均预期寿命的全国下降，以宣布宣布 联邦公共卫生紧急情况。证据表明，OUD是一种最适合管理的慢性健康状况 长期使用药物（MOUD）。穆德挽救生命，减少相关危害并增强 与其他药物使用障碍相比，缓解的可能性，患有Oud的人往往是 更多需要其他服务，感觉更孤立和边缘化，可用的恢复资产较少 （例如，工作，安全住房）并报告生活质量较低。这些持续的缺陷增加了生物行为应力 和预后的悲观主义，反过来又是治疗中断和随后的缓解的几率。有 需要额外的恢复支持服务（RSS）来帮助建立积极的社交网络并增加 教育，培训，就业和住房机会（统称为“恢复资本”），以增强 运作和生活质量。恢复社区中心（RCC）是设计的新兴国家实体 特别是为了帮助提供恢复资本和增强减轻和生活质量的增长。初步的 证据表明，RCC对有Oud的人起着特别有价值的作用，但希望他们强大的概念 从系统的研究角度来看 他们的临床和公共卫生公用事业以及成本效益。提高效率的发展 针对RCC的有效性研究，或者正在为正在维护的人或正在维持的药物治疗的人 Oud（p-moud）的处理，我们建议在全国范围内编排活动以参与多个 利益相关者并生产可行的可交付成果。该建议借鉴并建立在众多专业的基础上 以及学术资源和经验，包括我们已经建立的康复的存在 传播平台（即恢复研究所（RRI）； 6,000名公告读者，37,000个Twitter 追随者，每月24,000个网站访问者），由于其声誉和经验已签约 由Samhsa首先总结有关恢复支持服务的证据，然后促进第一个多元 利益相关者在全国范围内讨论，以推动RSS的科学。本着患者格言的精神， “没有我们，我们对我们一无所有”，我们制定了一项行动计划，该计划参与并涉及关键支持 - 在我们的网络计划的多个方面接收利益相关者。提出了五种类型的活动（即每月一次 开创性系列，飞行员资助，国家会议的研讨会演讲，顾问委员会会议与 RCC员工和与会者，对RCC人员的动手支持以跟踪和分析组织数据） 其中将导致混凝土可交付成果。这样做，RRI将成为已知的科学枢纽 通过RCC恢复支持，并将吸引，收集和传播支持该建筑物的辅助产品 累积的RCC科学可以阐明RCC在专门为P-MOUD提供支持中的作用。

项目成果

In natura heart rate variability predicts subsequent alcohol use in individuals in early recovery from alcohol use disorder.

自然地，心率变异性可以预测个体在酒精使用障碍早期恢复过程中随后的饮酒情况。

• DOI: 10.1111/adb.13306
• 发表时间: 2023
• 期刊: Addiction biology
• 影响因子: 3.4
• 作者: Eddie,David;Wieman,Sarah;Pietrzak,Agata;Zhai,Xiadi
• 通讯作者: Zhai,Xiadi

Time since last drink is positively associated with heart rate variability in outpatients with alcohol use disorder: Further evidence of psychophysiological recovery in early alcohol use disorder recovery.

距上次饮酒的时间与酒精使用障碍门诊患者的心率变异性呈正相关：早期酒精使用障碍恢复中心理生理恢复的进一步证据。

• DOI: 10.21203/rs.3.rs-2986948/v1
• 发表时间: 2023
• 期刊: Research square
• 作者: Eddie,David;Pietrzak,Agata;Ham,Jason
• 通讯作者: Ham,Jason