Research Career Scientist

研究职业科学家

• 批准号: 10754193
• 负责人: RICHARD Fergus ffrench WEIR
• 金额: --
• 依托单位: VA EASTERN COLORADO HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10754193
• 关键词: 3-Dimensional; Action Potentials; Address; Algorithms; Amputation; Appointment; Architecture; Area; Articulation; Award; Back; Belief; Biomedical Engineering; Blood Glucose; Caring; Cells; Chicago; Cladribine; Clinic; Clinical; Collaborations; Complex; Consensus; Contracts; Development; Devices; Distal; Doctor of Philosophy; Elasticity; Esthesia; Exclusion; Extramural Activities; Fingers; Forearm; Freedom; Funding; Fuzzy Logic; Goals; Grant; Hand; Healthcare; Heart; Iceland; Impairment; Implant; Individual; Inflammation; Joints; Laboratories; Lead; Licensing; Life Style; Limb Prosthesis; Limb structure; Maps; Maryland; Mechanics; Medical; Medical center; Mentors; Metals; Methods; Michigan; Modeling; Motor; Muscle; Musculoskeletal Equilibrium; National Institute of Neurological Disorders and Stroke; Nature; Nerve; Nervous System; Neurons; Occupational Therapist; Occupations; Optics; Pancreas; Paper; Pattern Recognition; Peripheral Nerves; Persons; Phantom Limb Pain; Physics; Post-Traumatic Stress Disorders; Postdoctoral Fellow; Printing; Process; Prosthesis; Prosthesis Design; Prosthetic rehabilitation; Provider; Publishing; Quality of life; Radial; Research; Research Personnel; Scientist; Secure; Sensory; Series; Severities; Signal Transduction; Site; Source; Students; Surface; Suspensions; System; Techniques; Technology; Time; Touch sensation; Training; Translating; Translations; United States National Institutes of Health; Upper Extremity; Vagus nerve structure; Veterans; Woman; Work; Wrist; arm; biomechanical model; blind; care delivery; career; clinical development; clinical translation; clinically relevant; design; experience; first-in-human; implantation; implanted sensor; improved; innovation; innovative technologies; interest; laboratory development; limb amputation; limb loss; meetings; neural; neuroregulation; novel; novel strategies; optogenetics; personalized approach; pressure; prophylactic; prosthetic hand; prototype; regenerative; rehabilitation research; research and development; research clinical testing; sensor; sensor technology; sensory feedback; sound

The over-arching goal of the Nominee’s, Richard F. ff. Weir, PhD, research is to improve the quality-of-life of veterans and individuals with limb loss. Upper-limb prosthetics research is an area of particular interest and relevance to VA. The Nominee and his team at the laboratory, the VA/CU Biomechatronics Development Laboratory, seek to improve the prosthetic options available to veterans with limb loss through the application of novel approaches and innovative technology to the development of clinically relevant prosthetic systems and solutions. The Nominee has been in the field of Prosthesis design and Rehabilitation Research in one form or another (Student, Post-doc, Scientist, Mentor) for over 25 years and has maintained extramural funding and developed a large network of collaborators in that time. The Nominee holds joint appointments at both VA as a Research Career Scientist and UC Denver|Anschtuz Medical Center in the Bioengineering Department. The Nominee currently mentors 1 CDA2 Candidate, 4 PhD candidates and 4 MS candidates and has mentored another 2 CDA Candidates, 8 PhD candidates and 22 MS candidates. The Nominee has aided and supported trainees in identifying and transitioning into translational careers. While it is a personal goal of the Nominee to be able to develop an artificial hand replacement capable of true dexterous manipulation for use by persons with upper-limb loss the Nominee and his team explore all aspects of the problem ranging from neural control and sensing; mechatronic design and development; novel actuator technologies; novel physical suspension/interface techniques; clinical deployment of these systems; methods to manage phantom limb pain; conducting clinical testing of the systems developed. The Nominee has had numerous contracts and grants to develop advanced limb systems for several different Federal agencies including VA, NIH, and DARPA. Over that time, in addition to being a VA Researcher and academic researcher, the Nominee completed the training required to become a clinical prosthetist, was National Director of Research for Advanced Arm Dynamics (AAD) for 2 years, (AAD is a national provider of upper-limb prosthetics care) and most recently founded Point Designs, LLC, as a conduit for translation of his Laboratory’s developments. It is these clinical experiences that inform the Nominee’s belief he should explore and provide practical solutions for immediately pressing clinical problems while also exploring ideas that push the envelope of current technology. The Nominee’s VA projects aim to address issues of more immediate clinical relevance like our project to develop artificial fingers suitable for women veterans [2I01RX002830(Weir)] while at the same time- exploring via a VA SPiRE [IK21RX003471(Weir)] using blood sugar as a fuel for a novel implanted fuel cell. Much of the Nominee’s non-VA research is centered around using optics to interrogate nerves. True dexterous manipulation needs sensory feedback (touch, pressure, force). Thus, a bidirectional control interface is needed, one for motor commands and one for sensation. The Nominee is exploring the use of optogenetic methods to non-invasively excite action potentials within neurons as a means of creating sensory percepts. Optogenetic neuromodulation of the vagus nerve has the potential for board reaching impact and indeed we have a VA SPiRE to explore optical modulation of the vagus as a potential treatment paradigm for PTSD [I21RX003894- 01(Fontaine)]. Another recent collaboration is one with Dr. Paul Cederna to develop a surface myoelectric sensor for his Regenerative peripheral nerve interface (RPNI) this is exciting because it looks like prophylactic use of RPNI’s with cut nerves might help mitigate phantom limb pain, a primary driver of prosthesis rejection, while at the same time creating/providing additional independent control sites. The barrier to using RPNI for control has been the need for some sort of implanted sensor [CDMRP W81XWH2110771(Kemp)]. All in all, I believe we are doing exciting and relevant research and to have the protected effort this VA RR&D RCS award provides has been truly enabling.

被提名人的首要目标是理查德·F·夫。威尔，博士，研究是为了提高生活质量 退伍军人和肢体丧失的个人。上肢假肢研究是一个特别感兴趣的领域， 与退伍军人事务部的相关性。被提名者和他在VA/CU生物机电开发实验室的团队 实验室，寻求通过应用以下技术来改善肢体缺失退伍军人可用的假肢选择 开发临床相关假体系统的新方法和创新技术 解决办法。被提名者曾在假体设计和康复研究领域以一种形式或 另一位(学生、博士后、科学家、导师)已超过25年，并一直维持着外部资金和 在那段时间里建立了一个庞大的合作者网络。被提名人在退伍军人管理局和退伍军人管理局担任联合职务 研究职业科学家和加州大学丹佛分校|生物工程部的Anschtuz医学中心。这个 被提名者目前指导了1名CDA2候选人，4名博士生和4名硕士候选人，并指导过 CDA考生2名，博士生8名，硕士研究生22名。被提名者已经帮助和支持 受训人员识别并过渡到翻译职业。 虽然被提名者的个人目标是能够开发一种能够 真正灵巧的手法，供上肢丧失的人使用，被提名者和他的团队探索所有 问题的各个方面，从神经控制和传感；机电一体化设计和开发；新颖 执行器技术；新的物理悬浮/接口技术；这些系统的临床部署； 方法管理幻肢疼痛；对开发的系统进行临床测试。被提名者有 有许多合同和赠款为几个不同的联邦机构开发先进的肢体系统 包括退伍军人事务部、美国国立卫生研究院和美国国防部高级研究计划局。在那段时间里，除了成为退伍军人事务部研究员和学术研究员外， 被提名者完成了成为临床修复师所需的培训，是国家研究主任 高级手臂动力学(AAD)2年(AAD是一家全国性的上肢假肢护理提供商)和 最近成立了Point Designs，LLC，作为翻译他的实验室发展的渠道。 正是这些临床经验告诉被提名者他应该探索和提供实用的 解决迫在眉睫的临床问题，同时探索突破当前 技术被提名者的退伍军人管理局项目旨在解决更直接的临床相关性问题，如我们的 开发适合女退伍军人的假指项目[2I01RX002830(伟尔)]，同时-- 通过VA尖顶[IK21RX003471(Weir)]探索将血糖用作新型植入燃料电池的燃料。 这位提名者的大部分非退伍军人研究都围绕着使用光学来询问神经。真正的灵巧 操纵需要感觉反馈(触摸、压力、力量)。因此，需要双向控制接口， 一个用于运动指令，另一个用于感觉。这位被提名者正在探索使用光遗传方法来 非侵入性地刺激神经元内的动作电位，作为创造感觉的一种手段。光遗传 迷走神经的神经调节有可能对板子产生影响，事实上我们有一个VA尖端 探索迷走神经光学调制作为治疗创伤后应激障碍的潜在范例[I21RX003894- 01(方丹)]。最近的另一项合作是与Paul Cederna博士合作开发表面肌电传感器 对于他的再生周围神经接口(RPNI)来说，这是令人兴奋的，因为它看起来像是预防性使用 切断神经的RPNI可能有助于缓解幻肢疼痛，而幻肢疼痛是假体排斥的主要驱动因素。 同时创建/提供额外的独立控制站点。使用RPNI进行控制的障碍是 需要某种植入式传感器[CDMRP W81XWH2110771(Kemp)]。 总而言之，我相信我们正在进行令人兴奋和相关的研究，并将这一受保护的努力与VA RR&D RCS大奖提供了真正令人信服的。

项目成果

Cellulose-acetate coating of carbon cloth diffusion layer for liquid-fed fuel cell applications.

• DOI: 10.1016/j.jpowsour.2022.231739
• 发表时间: 2022-06
• 期刊: Journal of power sources
• 影响因子: 9.2
• 作者: Jared Beshai;Thomas DiSorbo;Jacob Hutfles;Jacob L. Segil;Richard F. ff Weir;J. Pellegrino