Research Career Scientist

研究职业科学家

• 批准号: 10754193
• 负责人: RICHARD Fergus ffrench WEIR
• 金额: --
• 依托单位: VA EASTERN COLORADO HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10754193
• 关键词: 3-Dimensional; Action Potentials; Address; Algorithms; Amputation; Appointment; Architecture; Area; Articulation; Award; Back; Belief; Biomedical Engineering; Blood Glucose; Caring; Cells; Chicago; Cladribine; Clinic; Clinical; Collaborations; Complex; Consensus; Contracts; Development; Devices; Distal; Doctor of Philosophy; Elasticity; Esthesia; Exclusion; Extramural Activities; Fingers; Forearm; Freedom; Funding; Fuzzy Logic; Goals; Grant; Hand; Healthcare; Heart; Iceland; Impairment; Implant; Individual; Inflammation; Joints; Laboratories; Lead; Licensing; Life Style; Limb Prosthesis; Limb structure; Maps; Maryland; Mechanics; Medical; Medical center; Mentors; Metals; Methods; Michigan; Modeling; Motor; Muscle; Musculoskeletal Equilibrium; National Institute of Neurological Disorders and Stroke; Nature; Nerve; Nervous System; Neurons; Occupational Therapist; Occupations; Optics; Pancreas; Paper; Pattern Recognition; Peripheral Nerves; Persons; Phantom Limb Pain; Physics; Post-Traumatic Stress Disorders; Postdoctoral Fellow; Printing; Process; Prosthesis; Prosthesis Design; Prosthetic rehabilitation; Provider; Publishing; Quality of life; Radial; Research; Research Personnel; Scientist; Secure; Sensory; Series; Severities; Signal Transduction; Site; Source; Students; Surface; Suspensions; System; Techniques; Technology; Time; Touch sensation; Training; Translating; Translations; United States National Institutes of Health; Upper Extremity; Vagus nerve structure; Veterans; Woman; Work; Wrist; arm; biomechanical model; blind; care delivery; career; clinical development; clinical translation; clinically relevant; design; experience; first-in-human; implantation; implanted sensor; improved; innovation; innovative technologies; interest; laboratory development; limb amputation; limb loss; meetings; neural; neuroregulation; novel; novel strategies; optogenetics; personalized approach; pressure; prophylactic; prosthetic hand; prototype; regenerative; rehabilitation research; research and development; research clinical testing; sensor; sensor technology; sensory feedback; sound

The over-arching goal of the Nominee’s, Richard F. ff. Weir, PhD, research is to improve the quality-of-life of veterans and individuals with limb loss. Upper-limb prosthetics research is an area of particular interest and relevance to VA. The Nominee and his team at the laboratory, the VA/CU Biomechatronics Development Laboratory, seek to improve the prosthetic options available to veterans with limb loss through the application of novel approaches and innovative technology to the development of clinically relevant prosthetic systems and solutions. The Nominee has been in the field of Prosthesis design and Rehabilitation Research in one form or another (Student, Post-doc, Scientist, Mentor) for over 25 years and has maintained extramural funding and developed a large network of collaborators in that time. The Nominee holds joint appointments at both VA as a Research Career Scientist and UC Denver|Anschtuz Medical Center in the Bioengineering Department. The Nominee currently mentors 1 CDA2 Candidate, 4 PhD candidates and 4 MS candidates and has mentored another 2 CDA Candidates, 8 PhD candidates and 22 MS candidates. The Nominee has aided and supported trainees in identifying and transitioning into translational careers. While it is a personal goal of the Nominee to be able to develop an artificial hand replacement capable of true dexterous manipulation for use by persons with upper-limb loss the Nominee and his team explore all aspects of the problem ranging from neural control and sensing; mechatronic design and development; novel actuator technologies; novel physical suspension/interface techniques; clinical deployment of these systems; methods to manage phantom limb pain; conducting clinical testing of the systems developed. The Nominee has had numerous contracts and grants to develop advanced limb systems for several different Federal agencies including VA, NIH, and DARPA. Over that time, in addition to being a VA Researcher and academic researcher, the Nominee completed the training required to become a clinical prosthetist, was National Director of Research for Advanced Arm Dynamics (AAD) for 2 years, (AAD is a national provider of upper-limb prosthetics care) and most recently founded Point Designs, LLC, as a conduit for translation of his Laboratory’s developments. It is these clinical experiences that inform the Nominee’s belief he should explore and provide practical solutions for immediately pressing clinical problems while also exploring ideas that push the envelope of current technology. The Nominee’s VA projects aim to address issues of more immediate clinical relevance like our project to develop artificial fingers suitable for women veterans [2I01RX002830(Weir)] while at the same time- exploring via a VA SPiRE [IK21RX003471(Weir)] using blood sugar as a fuel for a novel implanted fuel cell. Much of the Nominee’s non-VA research is centered around using optics to interrogate nerves. True dexterous manipulation needs sensory feedback (touch, pressure, force). Thus, a bidirectional control interface is needed, one for motor commands and one for sensation. The Nominee is exploring the use of optogenetic methods to non-invasively excite action potentials within neurons as a means of creating sensory percepts. Optogenetic neuromodulation of the vagus nerve has the potential for board reaching impact and indeed we have a VA SPiRE to explore optical modulation of the vagus as a potential treatment paradigm for PTSD [I21RX003894- 01(Fontaine)]. Another recent collaboration is one with Dr. Paul Cederna to develop a surface myoelectric sensor for his Regenerative peripheral nerve interface (RPNI) this is exciting because it looks like prophylactic use of RPNI’s with cut nerves might help mitigate phantom limb pain, a primary driver of prosthesis rejection, while at the same time creating/providing additional independent control sites. The barrier to using RPNI for control has been the need for some sort of implanted sensor [CDMRP W81XWH2110771(Kemp)]. All in all, I believe we are doing exciting and relevant research and to have the protected effort this VA RR&D RCS award provides has been truly enabling.

提名人 Richard F. ff 的总体目标。威尔博士，研究是为了提高生活质量 退伍军人和肢体丧失的个人。上肢假肢研究是一个特别令人感兴趣的领域， 与 VA 的相关性。被提名者及其团队在 VA/CU 生物机电一体化开发实验室 实验室，寻求通过应用以下方法来改善肢体丧失退伍军人可用的假肢选择 开发临床相关假肢系统的新方法和创新技术 解决方案。被提名者以一种或多种形式从事假肢设计和康复研究领域 另一个（学生、博士后、科学家、导师）超过 25 年，并一直保持校外资助和 当时建立了一个庞大的合作者网络。被提名人在两个 VA 担任联合任命 研究职业科学家和加州大学丹佛分校|Anschtuz 医学中心生物工程系。这 提名者目前指导 1 名 CDA2 候选人、4 名博士候选人和 4 名硕士候选人，并已指导过 另外2名CDA候选人、8名博士候选人和22名硕士候选人。被提名人已提供协助和支持 学员识别并过渡到翻译职业。 虽然被提名者的个人目标是能够开发出能够实现以下功能的人工手替代品： 真正灵巧的操作，可供上肢丧失的人使用 提名者和他的团队探索了所有 问题的各个方面，从神经控制到传感；机电一体化设计与开发；小说 执行器技术；新颖的物理悬挂/界面技术；这些系统的临床部署； 治疗幻肢痛的方法；对开发的系统进行临床测试。被提名人有 拥有大量合同和拨款，为多个不同的联邦机构开发先进的肢体系统 包括 VA、NIH 和 DARPA。在那段时间里，除了担任 VA 研究员和学术研究员之外， 被提名者完成了成为临床假肢师所需的培训，是国家研究主任 Advanced Arm Dynamics (AAD) 为期 2 年（AAD 是上肢假肢护理的国家提供商）以及 最近成立了 Point Designs, LLC，作为转化其实验室开发成果的渠道。 正是这些临床经验使提名人相信他应该探索并提供实用的 解决紧迫的临床问题，同时探索突破当前极限的想法 技术。被提名者的 VA 项目旨在解决更直接的临床相关问题，例如我们的 开发适合女退伍军人的人造手指的项目[2I01RX002830(Weir)]，同时- 通过 VA SPiRE [IK21RX003471(Weir)] 进行探索，使用血糖作为新型植入燃料电池的燃料。 被提名人的大部分非 VA 研究都集中在使用光学来询问神经。真正的灵巧 操纵需要感官反馈（触摸、压力、力）。因此，需要一个双向控制接口， 一种用于运动命令，一种用于感觉。被提名者正在探索使用光遗传学方法 非侵入性地激发神经元内的动作电位，作为创建感官知觉的一种手段。光遗传学 迷走神经的神经调节具有影响板到达的潜力，事实上我们有 VA SPiRE 探索迷走神经的光调制作为 PTSD 的潜在治疗范例 [I21RX003894- 01（方丹）]。最近的另一项合作是与 Paul Cederna 博士合作开发表面肌电传感器 对于他的再生周围神经接口（RPNI）来说，这是令人兴奋的，因为它看起来像是预防性使用 带有切断神经的 RPNI 可能有助于减轻幻肢痛，这是假体排斥的主要驱动因素，而在 同时创建/提供额外的独立控制站点。使用 RPNI 进行控制的障碍是 需要某种植入传感器 [CDMRP W81XWH2110771(Kemp)]。 总而言之，我相信我们正在做令人兴奋且相关的研究，并在 VA RR&D 中做出受保护的努力 RCS 奖项提供了真正的支持。

项目成果

Cellulose-acetate coating of carbon cloth diffusion layer for liquid-fed fuel cell applications.

• DOI: 10.1016/j.jpowsour.2022.231739
• 发表时间: 2022-06
• 期刊: Journal of power sources
• 影响因子: 9.2
• 作者: Jared Beshai;Thomas DiSorbo;Jacob Hutfles;Jacob L. Segil;Richard F. ff Weir;J. Pellegrino