Developing a multiscale understanding of biophysical processes in sickle cell disease

建立对镰状细胞病生物物理过程的多尺度理解

• 批准号: 10756268
• 负责人: David Kevin Wood
• 金额: $ 7.07万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10756268
• 关键词: Biophysical Process; Sickle Cell Anemia

N/A per FOA PA-21-071.

按FOA PA-21-071规定。

项目成果

Ionophore-mediated swelling of erythrocytes as a therapeutic mechanism in sickle cell disease.

• DOI: 10.3324/haematol.2021.278666
• 发表时间: 2022-06-01
• 期刊: HAEMATOLOGICA
• 影响因子: 10.1
• 作者: Geisness, Athena C.;Azul, Melissa;Williams, Dillon;Szafraniec, Hannah;De Souza, Daniel C.;Higgins, John M.;Wood, David K.
• 通讯作者: Wood, David K.

High-throughput quantification of red blood cell deformability and oxygen saturation to probe mechanisms of sickle cell disease.

对红细胞变形性和氧饱和度进行高通量定量，以探讨镰状细胞病的机制。

• DOI: 10.1073/pnas.2313755120
• 发表时间: 2023
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1
• 作者: Williams,DillonC;Wood,DavidK
• 通讯作者: Wood,DavidK

Simultaneous quantification of blood rheology and oxygen saturation to evaluate affinity-modifying therapies in sickle cell disease.

• DOI: 10.1039/d2lc00623e
• 发表时间: 2022-10-25
• 期刊: Lab on a chip
• 影响因子: 6.1
• 作者: Hansen S;Wood DK
• 通讯作者: Wood DK

A microfluidic platform for simultaneous quantification of oxygen-dependent viscosity and shear thinning in sickle cell blood.

用于同时定量镰状细胞血中氧依赖性粘度和剪切稀化的微流体平台。

• DOI: 10.1063/1.5118212
• 发表时间: 2019
• 期刊: APL bioengineering
• 影响因子: 6
• 作者: Valdez,JoséM;Datta,YvonneH;Higgins,JohnM;Wood,DavidK
• 通讯作者: Wood,DavidK

Feature tracking microfluidic analysis reveals differential roles of viscosity and friction in sickle cell blood.

• DOI: 10.1039/d1lc01133b
• 发表时间: 2022-04-12
• 期刊: Lab on a chip
• 影响因子: 6.1