Core 1: Cellular Microenvironment Engineering

摘要 核心1 细胞微环境核心将提供使能技术并开发新的控制方法 细胞微环境及其对癌细胞迁移的影响。核心的主要目标 将探测微环境调节细胞迁移的信息告知数学模型，探测细胞 在与生理相关的环境中进行迁移，并开发高度并行化的平台 吞吐量研究。技术将包括但不限于控制机械设备的工具 环境、控制单元和环境体系结构、控制单元内的单元组织 微环境，控制化学梯度，控制细胞外化学，测量细胞迁移， 以及测量细胞内力的产生。此外，还将开发高通量细胞迁移工具 测量和高通量组织隔离。CELL微环境核心将支持两个项目1 和该中心内的项目2以及任何适用的试点项目。

Abstract Core 1 The Cell Microenvironment core will provide enabling technologies and develop new methods for controlling the cellular microenvironment and measuring its effect on cancer cell migration. The primary goals of the core will be to probe microenvironmental regulators of cell migration to inform mathematical models, probe cell migration within a physiologically relevant context, and develop highly parallelized platforms for high throughput studies. Technologies will include, but not be limited to, tools for controlling the mechanical environment, controlling cell and environment architecture, controlling cell organization within the microenvironment, controlling chemical gradients, controlling extracellular chemistry, measuring cell migration, and measuring cell force generation. In addition, tools will be developed for high-throughput cell migration measurement and high-throughput tissue isolation. The Cell Microenvironment core will support both Project 1 and Project 2 within this center as well as any applicable pilot projects.