Cortical Complications of Perimenopause and Obstructive Sleep Apnea in Underrepresented Middle-Aged Women with Type 2 Diabetes

代表性不足的 2 型糖尿病中年女性的围绝经期皮质并发症和阻塞性睡眠呼吸暂停

• 批准号: 10901012
• 负责人: Stacey Lynn Gorniak
• 金额: $ 68.9万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-20 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10901012
• 关键词: Adult; Age; Area; Biological Availability; Biological Markers; Biometry; Body mass index; C-reactive protein; Characteristics; Cholesterol; Chronic; Cognitive; Communities; Complex; Control Groups; Development; Endocrinology; Equation; Estrogens; Ethnic Population; Event; Female; Goals; Gonadal Steroid Hormones; Health; Heart Diseases; Hematological Disease; High Risk Woman; Hypoxemia; Impairment; Individual; Inflammation; Knowledge; Link; Lung diseases; Measurement; Measures; Mediating; Mediation; Menopause; Minority; Modeling; National Heart, Lung, and Blood Institute; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Obstructive Sleep Apnea; Outcome; Output; Oxygen; Oxyhemoglobin; Pathogenesis; Pathway interactions; Perimenopause; Persons; Play; Population; Postmenopause; Pulmonology; Recording of previous events; Reporting; Risk; Risk Factors; Role; Sensorimotor functions; Severities; Sleep; Sleep Apnea Syndromes; Sleep Deprivation; Sleep Disorders; Testosterone; Tissues; Underrepresented Minority; Vascular Dementia; Woman; Women' s Health; Work; aged; brain health; brain tissue; cognitive function; comparison control; ethnic minority population; evidence base; experience; functional disability; functional near infrared spectroscopy; health disparity; heart disease prevention; indexing; inflammatory marker; insight; interest; middle age; novel; poor sleep; racial minority population; racial population; recruit; sex; sleep health; sleep quantity; tissue oxygenation

Abstract More than 34 million individuals in the U.S. are living with Type 2 Diabetes (DM). Adult females who belong to underrepresented racial and ethnic groups are most negatively impacted by risks and complications associated with DM, including functional impairment in cognitive and sensorimotor actions. Prior work in understanding the cortical complications in persons with DM (including the development of vascular dementia (VD)) has focused on independent risk factors such as insufficient sleep and inflammation. DM complications have also been linked to obstructive sleep apnea (OSA) and sex-hormone changes during the transition to menopause; however, most studies have included only white non-Hispanic persons. Due to this, we have limited insight into the multifactorial causes of poor cortical health including DM, sex-hormone influences, inflammation, and OSA in the most dramatically impacted population living with DM—underrepresented women. In this project, we seek to fill this critical gap by clarifying how sex-hormones (estrogen and testosterone), inflammation, and OSA contribute together to the pathogenesis of cortical complications in underrepresented women living with DM. This proposed project is a logical extension of our recent work that provides mechanistic insight into the compound contributions of menopause and inflammation to cortical complications and functional impairment in underrepresented women with DM. Findings from this study will advance understanding of poor cortical health as a combined function of sex-hormone changes, inflammation, and OSA in underrepresented middle-aged women with DM. This information pushes forward beyond the knowledge of DM, insufficient sleep, inflammation, and underrepresented minority status as independent risk factors for VD development. This project aligns with NHLBI objectives of prevention of heart, lung, blood, and sleep diseases and priorities in in women’s health, sleep disorders, health disparities, and VD.

摘要 在美国，超过3400万人患有2型糖尿病（DM）。成年女性属于 代表性不足的种族和族裔群体受到相关风险和并发症的负面影响最大。 包括认知和感觉运动功能障碍。在了解 糖尿病患者的皮质并发症（包括血管性痴呆（VD）的发展）已被重点关注， 独立的风险因素，如睡眠不足和炎症。糖尿病并发症也是 与阻塞性睡眠呼吸暂停（OSA）和更年期过渡期间的性激素变化有关; 然而，大多数研究只包括非西班牙裔的白色人。因此，我们只能有限地了解 皮质健康状况不佳的多因素原因包括糖尿病、性激素影响、炎症和OSA 在与糖尿病代表性不足的妇女生活在一起的受影响最严重的人群中。本课题 我试图通过澄清性激素（雌激素和睾丸激素）、炎症和阻塞性睡眠呼吸暂停综合征（OSA） 共同导致糖尿病女性患者皮质并发症的发病机制。 这个拟议的项目是我们最近工作的一个逻辑延伸，它提供了对 绝经和炎症对皮质并发症和功能损害的复合作用 女性糖尿病患者比例偏低。这项研究的结果将促进对大脑皮层健康状况不佳的理解 作为性激素变化、炎症和OSA的联合作用， 女性DM这些信息推动了对DM，睡眠不足， 炎症和代表性不足的少数民族地位作为VD发展的独立风险因素。这 该项目符合NHLBI预防心脏、肺、血液和睡眠疾病的目标， 女性健康、睡眠障碍、健康差异和VD。