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Identification of small molecule RXFP3 ligands

Identification of small molecule RXFP3 ligands
小分子 RXFP3 配体的鉴定
批准号：
10916038
负责人：
Juan Marugan
金额：
$12.58万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10916038
关键词：
Addictive BehaviorAgonistAnimal ModelAnorexia NervosaAnxietyAutomobile DrivingBasic ScienceBehavioralBinge EatingBrain StemCell Culture SystemCell NucleusCellsCognitionCyclic AMPEatingEating DisordersFamilyHealthHumanHuman GenomeIn VitroInsulinInvestigationLigandsMental DepressionNational Center for Advancing Translational SciencesNeuronsObesityPainPeptidesProsencephalonRare DiseasesReceptor SignalingRelaxinResearchStressTranslationsWorkaddictionantagonistcognitive functiondrug candidateimprovedin vivonovelpain processingpharmacologicprogramsreceptorreceptor bindingrelaxin receptorresponsescreeningsmall moleculetooltreatment of anxiety disorders

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中文摘要
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英文摘要
The NCATS Early Translation Branch (ETB) hosts a broad and comprehensive program for the discovery of drug candidates directed towards rare diseases and pharmacological tools to probe the function of the human genome. ETB conducts research to understand the underlying principles driving the translation of basic research discoveries into tangible improvements in human health. Novel small molecule RXFP3 agonists and antagonists will be valuable tools to elucidate relaxin-3's function, as well as its actions at RXFP3 receptors. During this period, the project team has worked to develop and characterize screening hits to identify a potent RXFP3 modulator.
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会议论文
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Kinetic High Throughput Screening for Agonists and Inhibitors of the TRPML1 Ion channel
HTS Assay for Identification of Compounds that Reduce PNC Prevalence
国内基金
海外基金
Agonist-GPR119-Gs复合物的结构生物学研究
  • 批准号：
    32000851
  • 项目类别：
    青年科学基金项目
  • 资助金额：
    24.0万元
  • 批准年份：
    2020
  • 负责人：
    乔安娜
  • 依托单位：
    天津大学