Expanding on a new paradigm for MRI in pediatric congenital heart disease

拓展小儿先天性心脏病 MRI 的新范例

基本信息

批准号：
10622604
负责人：
Anthony G Christodoulou
金额：
$ 69.27万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-15 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10622604
关键词：
3D Print 4D MRI Acceleration Achievement Adopted Adult Affect Anatomy Anesthesia procedures Angiography Bayesian Modeling Biological Birth Blood Vessels Blood flow Breathing Cardiac Cardiovascular system Catheterization Child Childhood Clinical Collaborations Common Ventricle Compensation Complement Complex Computer Models Congenital Abnormality Contrast Media Data Data Pooling Data Set Defect Development Diagnostic Diagnostic Imaging Echocardiography Elements Engineering Evaluation Experimental Models Feedback Funding Gadolinium General Anesthesia Goals Heart Image Imaging Techniques Imaging technology In Vitro Infrastructure Institution Intratracheal Intubation Intubation Ionizing radiation Left Liquid substance Live Birth Logistics Longterm Follow-up Magnetic Resonance Imaging Mechanical ventilation Methods Modeling Motion Natural History Operative Surgical Procedures Outcome Patient Care Patient-Focused Outcomes Patients Pediatric Hospitals Performance Phase Physicians Physiologic pulse Physiology Population Positioning Attribute Public Health Recording of previous events Registries Repair Complex Resolution Risk Safety Scanning Sedation procedure Shapes Standardization Structure-Activity Relationship Surgeon Surgical Management Techniques Time Tissues Validation Ventricular Work anatomic imaging cardiac magnetic resonance imaging clinical translation computer framework congenital heart disorder deep neural network diagnostic value experience ferumoxytol hemodynamics image reconstruction imaging modality improved in vivo indexing mortality multi-scale modeling next generation novel off-label use palliation predictive tools prevent prospective reconstruction repaired respiratory standard of care success surgery outcome technique development time use tool virtual surgery

项目摘要

Project Summary Congenital heart disease (CHD) is the most common defect affecting approximately 1% of live births. Initially developed and optimized for adults, cardiac magnetic resonance imaging (CMR) is increasingly used in pediatric CHD patients to complement echocardiography and invasive angiography for anatomical and functional evaluation of the heart and blood vessels. For children, the non-invasiveness, unrestricted field of view, and absence of ionizing radiation make MRI an attractive imaging modality because many will need sequential imaging and long-term follow-up evaluations. However, current CMR for very young children requires general anesthesia and invasive intubation for acquisition of images that are of acceptable diagnostic quality. In the past 5 years, we pioneered ferumoxytol-enhanced CMR techniques that provide unprecedented image quality and diagnostic value; this technique has changed how CMR for pediatric CHD is clinically performed at our center. Our diagnostic application of ferumoxytol obviates any concerns about gadolinium accumulation in biologic tissues, In this renewal R01, we aim to develop next-generation CMR that can be performed without invasive intubation, and potentially with reduced anesthesia/sedation exposure. We further propose to build upon our improved CMR framework to develop advanced anatomical and hemodynamic modeling techniques for complex CHD. Together, these tools provide a CMR image-based strategy to help inform the patient's surgical plan and to ultimately predict surgical outcome. We will expand our multi-center collaborations to pool data and enable larger scale studies. Completion of the project will result in clinical deployment of new MRI pulse sequences, image acquisition and reconstruction strategies, and experimental and computational modeling methods.

项目摘要先天性心脏病（CHD）是影响活产1％的最常见缺陷。最初心脏磁共振成像（CMR）为成人开发和优化，越来越多地用于小儿冠心病患者以超声心动图和侵入性血管造影的补充，以进行解剖和心脏和血管的功能评估。对于儿童，无创，无限制的领域视图和缺乏电离辐射使MRI成为有吸引力的成像方式，因为许多人都需要顺序成像和长期随访评估。但是，目前针对非常小的孩子的CMR 需要一般麻醉和侵入性插管才能获取可接受的诊断图像质量。在过去的5年中，我们开创了富含铁氧酚增强的CMR技术，这些技术提供了前所未有的图像质量和诊断价值；这种技术改变了小儿冠心病的CMR临床方式在我们的中心表演。我们对铁氧托的诊断应用消除了对Gadolinium的任何担忧在这种续签R01中，在生物组织中积累，我们旨在发展下一代CMR 无浸润性插管，并且可能会减少麻醉/镇静暴露。我们进一步建议建立我们改进的CMR框架，以发展高级解剖和血流动力学复杂CHD的建模技术。这些工具共同提供了基于CMR图像的策略来帮助告知患者的手术计划，并最终预测手术结果。我们将扩大我们的多中心汇总数据并实现大规模研究的协作。该项目的完成将导致临床部署新的MRI脉冲序列，图像采集和重建策略以及实验和计算建模方法。

项目成果

期刊论文数量（25）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Accuracy, precision, and reproducibility of myocardial T1 mapping: A comparison of four T1 estimation algorithms for modified look-locker inversion recovery (MOLLI).

DOI：
10.1002/mrm.26565
发表时间：
2017-11
期刊：
Magnetic resonance in medicine
影响因子：
3.3
作者：
Shao J;Liu D;Sung K;Nguyen KL;Hu P
通讯作者：
Hu P

Accelerated phase contrast MRI using hybrid one- and two-sided flow encodings only (HOTFEO).

仅使用混合一侧和两侧流编码 (HOTFEO) 的加速相差 MRI。

DOI：
10.1002/nbm.3904
发表时间：
2018
期刊：
NMR in biomedicine
影响因子：
2.9
作者：
Wang,Da;Chien,Aichi;Shao,Jiaxin;Ali,FadilAbbas;Hu,Peng
通讯作者：
Hu,Peng

Ferumoxytol-Enhanced Cardiac Magnetic Resonance Angiography and 4D Flow: Safety and Utility in Pediatric and Adult Congenital Heart Disease.

DOI：
10.3390/children9121810
发表时间：
2022-11-24
期刊：
CHILDREN-BASEL
影响因子：
2.4
作者：
Renella, Pierangelo;Li, Jennifer;Prosper, Ashley E.;Finn, J. Paul;Nguyen, Kim-Lien
通讯作者：
Nguyen, Kim-Lien

Respiratory motion-resolved, self-gated 4D-MRI using rotating cartesian k-space (ROCK).