Expanding on a new paradigm for MRI in pediatric congenital heart disease

拓展小儿先天性心脏病 MRI 的新范例

• 批准号: 10622604
• 负责人: Anthony G Christodoulou
• 金额: $ 69.27万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10622604
• 关键词: 3D Print; 4D MRI; Acceleration; Achievement; Adopted; Adult; Affect; Anatomy; Anesthesia procedures; Angiography; Bayesian Modeling; Biological; Birth; Blood Vessels; Blood flow; Breathing; Cardiac; Cardiovascular system; Catheterization; Child; Childhood; Clinical; Collaborations; Common Ventricle; Compensation; Complement; Complex; Computer Models; Congenital Abnormality; Contrast Media; Data; Data Pooling; Data Set; Defect; Development; Diagnostic; Diagnostic Imaging; Echocardiography; Elements; Engineering; Evaluation; Experimental Models; Feedback; Funding; Gadolinium; General Anesthesia; Goals; Heart; Image; Imaging Techniques; Imaging technology; In Vitro; Infrastructure; Institution; Intratracheal Intubation; Intubation; Ionizing radiation; Left; Liquid substance; Live Birth; Logistics; Longterm Follow-up; Magnetic Resonance Imaging; Mechanical ventilation; Methods; Modeling; Motion; Natural History; Operative Surgical Procedures; Outcome; Patient Care; Patient-Focused Outcomes; Patients; Pediatric Hospitals; Performance; Phase; Physicians; Physiologic pulse; Physiology; Population; Positioning Attribute; Public Health; Recording of previous events; Registries; Repair Complex; Resolution; Risk; Safety; Scanning; Sedation procedure; Shapes; Standardization; Structure-Activity Relationship; Surgeon; Surgical Management; Techniques; Time; Tissues; Validation; Ventricular; Work; anatomic imaging; cardiac magnetic resonance imaging; clinical translation; computer framework; congenital heart disorder; deep neural network; diagnostic value; experience; ferumoxytol; hemodynamics; image reconstruction; imaging modality; improved; in vivo; indexing; mortality; multi-scale modeling; next generation; novel; off-label use; palliation; predictive tools; prevent; prospective; reconstruction; repaired; respiratory; standard of care; success; surgery outcome; technique development; time use; tool; virtual surgery

Project Summary Congenital heart disease (CHD) is the most common defect affecting approximately 1% of live births. Initially developed and optimized for adults, cardiac magnetic resonance imaging (CMR) is increasingly used in pediatric CHD patients to complement echocardiography and invasive angiography for anatomical and functional evaluation of the heart and blood vessels. For children, the non-invasiveness, unrestricted field of view, and absence of ionizing radiation make MRI an attractive imaging modality because many will need sequential imaging and long-term follow-up evaluations. However, current CMR for very young children requires general anesthesia and invasive intubation for acquisition of images that are of acceptable diagnostic quality. In the past 5 years, we pioneered ferumoxytol-enhanced CMR techniques that provide unprecedented image quality and diagnostic value; this technique has changed how CMR for pediatric CHD is clinically performed at our center. Our diagnostic application of ferumoxytol obviates any concerns about gadolinium accumulation in biologic tissues, In this renewal R01, we aim to develop next-generation CMR that can be performed without invasive intubation, and potentially with reduced anesthesia/sedation exposure. We further propose to build upon our improved CMR framework to develop advanced anatomical and hemodynamic modeling techniques for complex CHD. Together, these tools provide a CMR image-based strategy to help inform the patient's surgical plan and to ultimately predict surgical outcome. We will expand our multi-center collaborations to pool data and enable larger scale studies. Completion of the project will result in clinical deployment of new MRI pulse sequences, image acquisition and reconstruction strategies, and experimental and computational modeling methods.

项目总结

项目成果

Accuracy, precision, and reproducibility of myocardial T1 mapping: A comparison of four T1 estimation algorithms for modified look-locker inversion recovery (MOLLI).

• DOI: 10.1002/mrm.26565
• 发表时间: 2017-11
• 期刊: Magnetic resonance in medicine
• 影响因子: 3.3
• 作者: Shao J;Liu D;Sung K;Nguyen KL;Hu P
• 通讯作者: Hu P

Accelerated phase contrast MRI using hybrid one- and two-sided flow encodings only (HOTFEO).

仅使用混合一侧和两侧流编码 (HOTFEO) 的加速相差 MRI。

• DOI: 10.1002/nbm.3904
• 发表时间: 2018
• 期刊: NMR in biomedicine
• 影响因子: 2.9
• 作者: Wang,Da;Chien,Aichi;Shao,Jiaxin;Ali,FadilAbbas;Hu,Peng
• 通讯作者: Hu,Peng

Ferumoxytol-Enhanced Cardiac Magnetic Resonance Angiography and 4D Flow: Safety and Utility in Pediatric and Adult Congenital Heart Disease.

• DOI: 10.3390/children9121810
• 发表时间: 2022-11-24
• 期刊: CHILDREN-BASEL
• 影响因子: 2.4
• 作者: Renella, Pierangelo;Li, Jennifer;Prosper, Ashley E.;Finn, J. Paul;Nguyen, Kim-Lien
• 通讯作者: Nguyen, Kim-Lien

Respiratory motion-resolved, self-gated 4D-MRI using rotating cartesian k-space (ROCK).

• DOI: 10.1002/mp.12139
• 发表时间: 2017-04
• 期刊: Medical physics
• 影响因子: 3.8
• 作者: Han F;Zhou Z;Cao M;Yang Y;Sheng K;Hu P
• 通讯作者: Hu P

Automatic segmentation of peripheral arteries and veins in ferumoxytol-enhanced MR angiography.

费鲁莫托增强磁共振血管造影中外周动脉和静脉的自动分割。

• DOI: 10.1002/mrm.29026
• 发表时间: 2022
• 期刊: Magnetic resonance in medicine
• 影响因子: 3.3
• 作者: Ghodrati,Vahid;Rivenson,Yair;Prosper,Ashley;deHaan,Kevin;Ali,Fadil;Yoshida,Takegawa;Bedayat,Arash;Nguyen,Kim-Lien;Finn,JPaul;Hu,Peng
• 通讯作者: Hu,Peng