SSFP Cardiovascular MR Imaging on 3.0T Using Unified-Coil Local Shimming
使用统一线圈局部匀场在 3.0T 上进行 SSFP 心血管 MR 成像
基本信息
- 批准号:10318662
- 负责人:
- 金额:$ 67.51万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-12-15 至 2024-11-30
- 项目状态:已结题
- 来源:
- 关键词:AbdomenAdoptionAirAngiographyBreathingCardiacCardiovascular DiseasesCardiovascular systemCause of DeathChestClinicalClinical ManagementCoronaryDevelopmentEcho-Planar ImagingFeedbackFrequenciesGoalsHeartImageImaging TechniquesLungMagnetic ResonanceMagnetic Resonance ImagingMagnetismMethodsMorphologic artifactsMotionMyocardial tissueNoiseOrganPenetrationPerformancePredispositionPropertyProtocols documentationRF coilResolutionRespirationSafetyScanningSignal TransductionSourceSystemTechniquesTechnologyTimeTissuesVariantVendorVertebral columnWorkbasehealthy volunteerheart functionhuman subjectimprovedinnovationmultitasknovelpreventrespiratory
项目摘要
Abstract
Cardiovascular disease is the leading cause of death globally. Cardiovascular magnetic resonance (CMR)
is routinely used in the clinical management of cardiovascular disease and is the standard method for the
assessment of cardiac function and myocardial tissue properties. Today, most clinical CMR studies are still
conducted on 1.5T scanners because of their availability and robustness in executing CMR protocols. In
general, 3.0T provides higher SNR, spatial resolution, and reduced scan time than 1.5T. However, the
increased B0 field strength also poses technical challenges for CMR. A major challenge is the susceptibility or
off-resonance artifacts due to worsened B0 field inhomogeneity.
In the last two decades, steady-state free precession (SSFP) has revolutionized CMR on 1.5T because it
boosts SNR and contrast to noise ratio (CNR) markedly over gradient-echo based acquisitions. However, its
routine use on 3.0T has been inconsistent despite continuously improving B0 homogeneity and shimming
capabilities. Therefore, gradient-echo based acquisitions are still routinely used, such as for cine imaging,
cardiac relaxometry, and coronary MRA, negating the major advantages of 3.0T for CMR. Due to the distance
of standard whole-body shimming coils from the target organ, they only provide shimming capabilities up to the
second-order spherical harmonic (SH), and are incapable of shimming higher-order localized field variations
such as those present near the heart-lung interface. This remains an unmet challenge.
In this project, we will apply a novel unified shim-RF coil technique to overcome the primary limitation in
3.0T CMR. We will develop a unified shim-RF coil and validate its safety and high-order shimming capability
(Aim 1). We will develop a respiratory motion-resolved B0 field mapping technique based on our low-rank
Multitasking framework and real-time shim circuits to allow dynamic shimming for free breathing CMR (Aim 2).
We will then validate the technology in human subjects on 3.0T (Aim 3). Successful completion of this project
will enable robust SSFP CMR on 3.0T, a major technical challenge, which allows reliable high-resolution, high-
SNR CMR, including but not limited to cine and coronary MRA. This novel cardiac shimming system has the
potential to have a major impact in accelerating the clinical adoption of 3.0T CMR.
抽象的
心血管疾病是全球死亡的主要原因。心血管磁共振 (CMR)
常规用于心血管疾病的临床治疗,是心血管疾病的标准方法
评估心脏功能和心肌组织特性。如今,大多数临床 CMR 研究仍处于
由于其在执行 CMR 协议方面的可用性和稳健性,因此在 1.5T 扫描仪上进行。在
一般来说,3.0T 比 1.5T 提供更高的信噪比、空间分辨率并缩短扫描时间。然而,
B0 场强的增加也给 CMR 带来了技术挑战。一个主要的挑战是敏感性或
B0 场不均匀性恶化导致的偏共振伪影。
在过去二十年中,稳态自由进动 (SSFP) 彻底改变了 1.5T 上的 CMR,因为它
与基于梯度回波的采集相比,显着提高了 SNR 和对比度噪声比 (CNR)。然而,其
尽管不断改进 B0 均匀性和匀场,但 3.0T 的常规使用仍不一致
能力。因此,基于梯度回波的采集仍然常规使用,例如用于电影成像、
心脏舒张测量和冠状动脉 MRA,否定了 3.0T 对于 CMR 的主要优势。由于距离
来自目标器官的标准全身匀场线圈,它们仅提供高达
二阶球谐函数 (SH),并且无法匀场高阶局部场变化
例如心肺界面附近的那些。这仍然是一个尚未解决的挑战。
在这个项目中,我们将应用一种新颖的统一匀场射频线圈技术来克服主要限制
3.0T CMR。我们将开发统一的匀场-射频线圈并验证其安全性和高阶匀场能力
(目标 1)。我们将基于我们的低秩开发呼吸运动解析 B0 场映射技术
多任务框架和实时匀场电路可实现自由呼吸 CMR 的动态匀场(目标 2)。
然后,我们将在 3.0T 上对人类受试者验证该技术(目标 3)。本项目顺利完成
将在 3.0T 上实现强大的 SSFP CMR,这是一项重大技术挑战,它允许可靠的高分辨率、高分辨率
SNR CMR,包括但不限于电影和冠状动脉 MRA。这种新颖的心脏匀场系统具有
可能对加速 3.0T CMR 的临床应用产生重大影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Anthony G Christodoulou其他文献
Multicontrast 3D automated segmentation of cardiovascular images
- DOI:
10.1186/1532-429x-18-s1-o114 - 发表时间:
2016-01-27 - 期刊:
- 影响因子:
- 作者:
Matthew Bramlet;Anthony G Christodoulou;Brad Sutton - 通讯作者:
Brad Sutton
Anthony G Christodoulou的其他文献
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{{ truncateString('Anthony G Christodoulou', 18)}}的其他基金
Fully Quantitative Low-Dose, Motion-Resolved Dynamic Contrast-Enhanced MRI in Pancreatic Adenocarcinoma
胰腺癌的全定量低剂量运动分辨动态对比增强 MRI
- 批准号:
10646508 - 财政年份:2022
- 资助金额:
$ 67.51万 - 项目类别:
Fully Quantitative Low-Dose, Motion-Resolved Dynamic Contrast-Enhanced MRI in Pancreatic Adenocarcinoma
胰腺癌的全定量低剂量运动分辨动态对比增强 MRI
- 批准号:
10419915 - 财政年份:2022
- 资助金额:
$ 67.51万 - 项目类别:
SSFP Cardiovascular MR Imaging on 3.0T Using Unified-Coil Local Shimming
使用统一线圈局部匀场在 3.0T 上进行 SSFP 心血管 MR 成像
- 批准号:
10530641 - 财政年份:2020
- 资助金额:
$ 67.51万 - 项目类别:
SSFP Cardiovascular MR Imaging on 3.0T Using Unified-Coil Local Shimming
使用统一线圈局部匀场在 3.0T 上进行 SSFP 心血管 MR 成像
- 批准号:
10152406 - 财政年份:2020
- 资助金额:
$ 67.51万 - 项目类别:
Motion-Resolved, Comprehensive Quantitative Tissue Characterization Using MR Multitasking
使用 MR 多任务处理进行运动解析、全面的定量组织表征
- 批准号:
10376180 - 财政年份:2019
- 资助金额:
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Motion-Resolved, Comprehensive Quantitative Tissue Characterization Using MR Multitasking
使用 MR 多任务处理进行运动解析、全面的定量组织表征
- 批准号:
9766063 - 财政年份:2019
- 资助金额:
$ 67.51万 - 项目类别:
Motion-Resolved, Comprehensive Quantitative Tissue Characterization Using MR Multitasking
使用 MR 多任务处理进行运动解析、全面的定量组织表征
- 批准号:
9886248 - 财政年份:2019
- 资助金额:
$ 67.51万 - 项目类别:
Expanding on a new paradigm for MRI in pediatric congenital heart disease
拓展小儿先天性心脏病 MRI 的新范例
- 批准号:
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- 资助金额:
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Expanding on a new paradigm for MRI in pediatric congenital heart disease
拓展小儿先天性心脏病 MRI 的新范例
- 批准号:
10622604 - 财政年份:2015
- 资助金额:
$ 67.51万 - 项目类别:
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