SSFP Cardiovascular MR Imaging on 3.0T Using Unified-Coil Local Shimming

使用统一线圈局部匀场在 3.0T 上进行 SSFP 心血管 MR 成像

• 批准号: 10530641
• 负责人: Anthony G Christodoulou
• 金额: $ 65.84万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-15 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10530641
• 关键词: Abdomen; Acceleration; Adoption; Air; Angiography; Breathing; Cardiac; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Chest; Clinical; Clinical Management; Compensation; Coronary; Development; Echo-Planar Imaging; Feedback; Frequencies; Goals; Heart; Image; Imaging Techniques; Lung; Magnetic Resonance; Magnetic Resonance Imaging; Magnetism; Maps; Methods; Morphologic artifacts; Motion; Myocardial tissue; Noise; Organ; Penetration; Performance; Predisposition; Property; Protocols documentation; RF coil; Resolution; Respiration; Safety; Scanning; Signal Transduction; Source; System; Techniques; Time; Tissues; Variant; Vendor; Vertebral column; Work; healthy volunteer; heart function; human subject; improved; innovation; multitask; novel; prevent; respiratory; technology validation

Abstract Cardiovascular disease is the leading cause of death globally. Cardiovascular magnetic resonance (CMR) is routinely used in the clinical management of cardiovascular disease and is the standard method for the assessment of cardiac function and myocardial tissue properties. Today, most clinical CMR studies are still conducted on 1.5T scanners because of their availability and robustness in executing CMR protocols. In general, 3.0T provides higher SNR, spatial resolution, and reduced scan time than 1.5T. However, the increased B0 field strength also poses technical challenges for CMR. A major challenge is the susceptibility or off-resonance artifacts due to worsened B0 field inhomogeneity. In the last two decades, steady-state free precession (SSFP) has revolutionized CMR on 1.5T because it boosts SNR and contrast to noise ratio (CNR) markedly over gradient-echo based acquisitions. However, its routine use on 3.0T has been inconsistent despite continuously improving B0 homogeneity and shimming capabilities. Therefore, gradient-echo based acquisitions are still routinely used, such as for cine imaging, cardiac relaxometry, and coronary MRA, negating the major advantages of 3.0T for CMR. Due to the distance of standard whole-body shimming coils from the target organ, they only provide shimming capabilities up to the second-order spherical harmonic (SH), and are incapable of shimming higher-order localized field variations such as those present near the heart-lung interface. This remains an unmet challenge. In this project, we will apply a novel unified shim-RF coil technique to overcome the primary limitation in 3.0T CMR. We will develop a unified shim-RF coil and validate its safety and high-order shimming capability (Aim 1). We will develop a respiratory motion-resolved B0 field mapping technique based on our low-rank Multitasking framework and real-time shim circuits to allow dynamic shimming for free breathing CMR (Aim 2). We will then validate the technology in human subjects on 3.0T (Aim 3). Successful completion of this project will enable robust SSFP CMR on 3.0T, a major technical challenge, which allows reliable high-resolution, high- SNR CMR, including but not limited to cine and coronary MRA. This novel cardiac shimming system has the potential to have a major impact in accelerating the clinical adoption of 3.0T CMR.

抽象的 心血管疾病是全球死亡的主要原因。心血管磁共振 (CMR) 常规用于心血管疾病的临床治疗，是心血管疾病的标准方法 评估心脏功能和心肌组织特性。如今，大多数临床 CMR 研究仍处于 由于其在执行 CMR 协议方面的可用性和稳健性，因此在 1.5T 扫描仪上进行。在 一般来说，3.0T 比 1.5T 提供更高的信噪比、空间分辨率并缩短扫描时间。然而， B0 场强的增加也给 CMR 带来了技术挑战。一个主要的挑战是敏感性或 B0 场不均匀性恶化导致的偏共振伪影。 在过去二十年中，稳态自由进动 (SSFP) 彻底改变了 1.5T 上的 CMR，因为它 与基于梯度回波的采集相比，显着提高了 SNR 和对比度噪声比 (CNR)。然而，其 尽管不断改进 B0 均匀性和匀场，但 3.0T 的常规使用仍不一致 能力。因此，基于梯度回波的采集仍然常规使用，例如用于电影成像、 心脏舒张测量和冠状动脉 MRA，否定了 3.0T 对于 CMR 的主要优势。由于距离 来自目标器官的标准全身匀场线圈，它们仅提供高达 二阶球谐函数 (SH)，并且无法匀场高阶局部场变化 例如心肺界面附近的那些。这仍然是一个尚未解决的挑战。 在这个项目中，我们将应用一种新颖的统一匀场射频线圈技术来克服主要限制 3.0T CMR。我们将开发统一的匀场-射频线圈并验证其安全性和高阶匀场能力 （目标 1）。我们将基于我们的低秩开发呼吸运动解析 B0 场映射技术 多任务框架和实时匀场电路可实现自由呼吸 CMR 的动态匀场（目标 2）。 然后，我们将在 3.0T 上对人类受试者验证该技术（目标 3）。本项目顺利完成 将在 3.0T 上实现强大的 SSFP CMR，这是一项重大技术挑战，它允许可靠的高分辨率、高分辨率 SNR CMR，包括但不限于电影和冠状动脉 MRA。这种新颖的心脏匀场系统具有 可能对加速 3.0T CMR 的临床应用产生重大影响。