Childhood Allergy and the NeOnatal Environment (CANOE) ECHO Pediatric Follow-Up and New Enrollment
儿童过敏和新生儿环境 (CANOE) ECHO 儿科随访和新入组
基本信息
- 批准号:10744839
- 负责人:
- 金额:$ 128.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:AffectAgeAir PollutionAllergicAllergic DiseaseAsthmaAtopic DermatitisBacteriaBiological MarkersBiologyBirthCalendarCensusesCharacteristicsChildChildhoodChildhood AsthmaClinicalCommunitiesComplexConceptionsDNA MethylationDataDevelopmentDiagnosisDiseaseDisparityEnrollmentEnvironmentEnvironmental ExposureEnvironmental HealthEnvironmental Risk FactorEpigenetic ProcessEpithelial CellsEpitheliumEthnic OriginExposure toFunctional disorderFundingGene ExpressionGene Expression ProfileGeneticGenetic RiskGenetic TranscriptionGeographyGoalsGreen spaceHealth PromotionHouseholdHumanHypersensitivityIncidenceIndividualIndividual AdjustmentInfantInflammationInterventionLifeLinkLow incomeMediatingModificationMolecularMolecular TargetNasal EpitheliumNeighborhoodsNeonatalNewborn InfantNoseParticipantPathogenesisPathogenicityPathway interactionsPatternPopulation DensityPositioning AttributePregnancyPregnant WomenPrevalencePreventionPrevention strategyProtocols documentationPublishingRaceRecurrenceRiskSkinSkin colonizationStructureSwabTechnologyTestingWheezingWomanairway epitheliumallergic responseasthma exacerbationasthma preventionbacterial communitycohortdata harmonizationdisparity reductionearly life exposurefollow-upgene environment interactionhealth disparityimmune activationinfancyinsightmicrobial colonizationmicrobiomemultidisciplinarymultiple omicsprenatalprogramsrecruitrespiratoryresponsesexskin microbiomesocial health determinantstranscriptomicstreatment strategy
项目摘要
PROJECT ABSTRACT
Asthma is a complex, heterogenous condition with both genetic and environmental factors contributing to
disease. The epithelial barrier is the interface between environmental exposures and the host. Gene-
environment interaction studies demonstrate that early life exposures modify genetic risks in asthma, and
epigenetic changes, such as DNA methylation (DNAm) may mediate these effects. Additionally, epithelial
transcriptional changes link to childhood asthma. We propose to use both of these powerful technologies to
provide a mechanistic link from environmental exposure to asthma inception. We hypothesize that exposures
at the epithelial barrier related to the community (air pollution, nearby green space) and the individual
(microbiome) alter epithelial DNAm and transcriptional responses to promote the development of asthma. To
evaluate this hypothesis, we will leverage the ECHO Cohort protocol 3.0 to determine how prenatal and early
life individual and neighborhood level exposures contribute to nasal epithelial changes in infancy to promote
the development of wheezing (aim 1), determine how the these exposures, including the skin microbiome,
influence skin epithelial changes to promote atopic dermatitis and wheezing (aim 2), and elucidate how
individual and neighborhood characteristics influence maternal nasal epigenetic changes throughout
pregnancy, and how these changes relate to allergic diseases in the child (aim 4). Finally, we will follow
existing ECHO participants and recruit 350 pregnant women and 50 women preconception that give birth (for a
of total 400 births) into ECHO Cohort protocol 3.0 (aim 3). Importantly, throughout this proposal, we seek to
disentangle factors that may underlie health disparities by identifying the mechanisms by which environmental
exposures (that are often associated and conflated with race) cause asthma. We will identify precise molecular
targets for diagnosis and prevention. This information can be used to (1) establish non-invasive biomarkers
(from nasal or skin swabs) to identify infants at risk for asthma, (2) develop treatment strategies based on
altering patterns of microbial colonization or epithelial gene expression to promote health, and (3) identify
actionable exposures that underly health disparities for intervention.
项目摘要
哮喘是一种复杂的、异质性的疾病,遗传和环境因素都会导致哮喘
疾病。上皮屏障是环境暴露和宿主之间的界面。基因-
环境相互作用研究表明,早期生活暴露会改变哮喘的遗传风险,并且
表观遗传变化,如DNA甲基化(DNaM)可能介导这些效应。此外,上皮性
转录变化与儿童哮喘有关。我们建议使用这两种强大的技术来
提供从环境暴露到哮喘发病的机械性联系。我们假设暴露在
在与社区(空气污染、附近的绿地)和个人有关的上皮屏障
(微生物组)改变上皮dNaM和转录反应以促进哮喘的发展。至
评估这一假设,我们将利用Echo Cohort协议3.0来确定产前和早期
生活、个人和邻里层面的暴露促进婴儿期鼻上皮的变化
喘息的发展(目标1),确定这些暴露如何,包括皮肤微生物组,
影响皮肤上皮变化以促进特应性皮炎和喘息(目标2),并阐明如何
个体和邻里特征自始至终影响着母亲鼻部的表观遗传变化
怀孕,以及这些变化与儿童过敏性疾病的关系(目标4)。最后,我们将跟随
现有的ECHO参与者招募了350名孕妇和50名先入为主的分娩妇女(对于
在400个新生儿中)进入回声队列方案3.0(目标3)。重要的是,在整个提案中,我们寻求
通过确定导致健康差异的机制来理清可能导致健康差异的因素
暴露(经常与种族联系在一起)会导致哮喘。我们将识别出精确的分子
诊断和预防的目标。该信息可用于(1)建立非侵入性生物标志物
(通过鼻拭子或皮肤拭子)以识别有哮喘风险的婴儿,(2)根据以下情况制定治疗策略
改变微生物定植或上皮基因表达的模式以促进健康,以及(3)确定
不利于健康差距的可采取行动的暴露,以进行干预。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Anne Marie Singh其他文献
Anne Marie Singh的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Anne Marie Singh', 18)}}的其他基金
S. aureus and Regulatory T cells in the Failure of Oral Tolerance
金黄色葡萄球菌和调节性 T 细胞在口服耐受失败中的作用
- 批准号:
8664793 - 财政年份:2013
- 资助金额:
$ 128.63万 - 项目类别:
S. aureus and Regulatory T cells in the Failure of Oral Tolerance
金黄色葡萄球菌和调节性 T 细胞在口服耐受失败中的作用
- 批准号:
8581436 - 财政年份:2013
- 资助金额:
$ 128.63万 - 项目类别:
相似国自然基金
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
- 批准号:JCZRQN202500010
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
- 批准号:2025JJ70209
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
- 批准号:
- 批准年份:2024
- 资助金额:0 万元
- 项目类别:面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
- 批准号:2023JJ50274
- 批准年份:2023
- 资助金额:0.0 万元
- 项目类别:省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
- 批准号:
- 批准年份:2022
- 资助金额:33 万元
- 项目类别:地区科学基金项目
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
- 批准号:
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
- 批准号:n/a
- 批准年份:2022
- 资助金额:10.0 万元
- 项目类别:省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
- 批准号:81973577
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
- 批准号:81602908
- 批准年份:2016
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
- 批准号:81501928
- 批准年份:2015
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
相似海外基金
PROTEMO: Emotional Dynamics Of Protective Policies In An Age Of Insecurity
PROTEMO:不安全时代保护政策的情绪动态
- 批准号:
10108433 - 财政年份:2024
- 资助金额:
$ 128.63万 - 项目类别:
EU-Funded
The role of dietary and blood proteins in the prevention and development of major age-related diseases
膳食和血液蛋白在预防和发展主要与年龄相关的疾病中的作用
- 批准号:
MR/X032809/1 - 财政年份:2024
- 资助金额:
$ 128.63万 - 项目类别:
Fellowship
Atomic Anxiety in the New Nuclear Age: How Can Arms Control and Disarmament Reduce the Risk of Nuclear War?
新核时代的原子焦虑:军控与裁军如何降低核战争风险?
- 批准号:
MR/X034690/1 - 财政年份:2024
- 资助金额:
$ 128.63万 - 项目类别:
Fellowship
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341426 - 财政年份:2024
- 资助金额:
$ 128.63万 - 项目类别:
Continuing Grant
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341424 - 财政年份:2024
- 资助金额:
$ 128.63万 - 项目类别:
Continuing Grant
Doctoral Dissertation Research: Effects of age of acquisition in emerging sign languages
博士论文研究:新兴手语习得年龄的影响
- 批准号:
2335955 - 财政年份:2024
- 资助金额:
$ 128.63万 - 项目类别:
Standard Grant
The economics of (mis)information in the age of social media
社交媒体时代(错误)信息的经济学
- 批准号:
DP240103257 - 财政年份:2024
- 资助金额:
$ 128.63万 - 项目类别:
Discovery Projects
How age & sex impact the transcriptional control of mammalian muscle growth
你多大
- 批准号:
DP240100408 - 财政年份:2024
- 资助金额:
$ 128.63万 - 项目类别:
Discovery Projects
Supporting teachers and teaching in the age of Artificial Intelligence
支持人工智能时代的教师和教学
- 批准号:
DP240100111 - 财政年份:2024
- 资助金额:
$ 128.63万 - 项目类别:
Discovery Projects
Enhancing Wahkohtowin (Kinship beyond the immediate family) Community-based models of care to reach and support Indigenous and racialized women of reproductive age and pregnant women in Canada for the prevention of congenital syphilis
加强 Wahkohtowin(直系亲属以外的亲属关系)以社区为基础的护理模式,以接触和支持加拿大的土著和种族育龄妇女以及孕妇,预防先天梅毒
- 批准号:
502786 - 财政年份:2024
- 资助金额:
$ 128.63万 - 项目类别:
Directed Grant