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Assay optimization and screening for measuring the kinetics of antibacterial resistance emergence

Assay optimization and screening for measuring the kinetics of antibacterial resistance emergence
用于测量抗菌药物耐药性出现动力学的测定优化和筛选
批准号：
10919706
负责人：
Anton Simeonov
金额：
$12.58万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10919706
关键词：
AddressAntibiotic ResistanceBacterial Drug ResistanceBacterial InfectionsBiological AssayClinicalCombined Modality TherapyDrug CombinationsDrug KineticsDrug resistanceFiberInfectionKineticsLiquid substanceMeasuresModelingNational Center for Advancing Translational SciencesPharmaceutical PreparationsPublic HealthSystemminiaturizeresponsescreening

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中文摘要
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英文摘要
Antibiotic resistance is one of the major threats to public health today. To address this problem requires an urgent comprehensive approach. Strategic and multi-targeted combination therapy has been increasingly used clinically to treat bacterial infections. Collaborators at the FDA have developed a hollow-fibre infection model to assess the emergence of drug resistance in response to drug combinations (2 and 3 drugs), however, this is limited in its throughput. To address this, the project team is leveraging NCATS's liquid handling capabilities to screen bacterial responses to combinations and measure the kinetics of the emergence of drug resistance.
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