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Inhibition of Regeneration Restraining Pathways to Promote Healing

Inhibition of Regeneration Restraining Pathways to Promote Healing
抑制再生抑制途径以促进愈合
批准号：
10928440
负责人：
Luis Andres Garza
金额：
$36.03万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
项目状态：
已结题
起止时间：
2023-09-18 至 2024-08-31
来源：
https://reporter.nih.gov/project-details/10928440
关键词：
AnimalsAntibodiesAutoimmune DiseasesBacterial InfectionsBiologicalBiological AssayBiological Response Modifier TherapyBlood CellsBlood VesselsCASP1 geneCTLA4 geneCaspaseCaspase InhibitorCellsClinicDataDouble-Stranded RNAElementsEmbryonic DevelopmentEpitheliumExcisionFasciaFc ReceptorFutureGenesGeneticGoalsGrantHairHair follicle structureHealthHumanImmuneImmune systemInfectionInfiltrationInjuryIntestinesKnockout MiceLGR5 geneMediatingMonoclonal AntibodiesMusNatural regenerationNeomycin resistance geneNervePD-1/PD-L1Pathway interactionsPatientsPublishingRegenerative capacityReportingResearchSkinSmall Interfering RNATLR2 geneTLR3 geneTestingTherapeuticTissuesUntranslated RNAantagonistanti-PD-L1 antibodiesautoinflammatory diseasescancer therapycell typecheckpoint therapyclinical careepithelium regenerationgain of functionhealingimprovedinhibitor therapyinjury recoveryinsightkeratinocyteloss of functionneutralizing antibodynovelnovel therapeuticsnull mutationorgan injurypharmacologicpreventprogramsreceptorregenerativeregenerative therapyrepairedresponseresponse to injuryrestraintside effectsingle-cell RNA sequencingskin woundstem cellstherapy developmentwound

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Project Summary Abstract The long term objective of the proposed research is to enhance healing after injury that is often slow and incomplete. We hypothesized that injury to epithelial tissue like skin and gut share commonalities in healing, with some native injury responses which actually restrain healing. The goal of this grant is to define the mechanism of this restraint in hopes of developing therapies to enhance healing. We will test if inhibition of these pathways that restrain healing can improve regeneration after injury or infection to the gut or skin in the hopes of suggesting a new class of therapeutics to aid healing from diverse injuries.
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