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Inhibition of Regeneration Restraining Pathways to Promote Healing

抑制再生抑制途径以促进愈合

基本信息

批准号：
10928440
负责人：
Luis Andres Garza
金额：
$ 36.03万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-18 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10928440
关键词：
Animals Antibodies Autoimmune Diseases Bacterial Infections Biological Biological Assay Biological Response Modifier Therapy Blood Cells Blood Vessels CASP1 gene CTLA4 gene Caspase Caspase Inhibitor Cells Clinic Data Double-Stranded RNA Elements Embryonic Development Epithelium Excision Fascia Fc Receptor Future Genes Genetic Goals Grant Hair Hair follicle structure Health Human Immune Immune system Infection Infiltration Injury Intestines Knockout Mice LGR5 gene Mediating Monoclonal Antibodies Mus Natural regeneration Neomycin resistance gene Nerve PD-1/PD-L1 Pathway interactions Patients Publishing Regenerative capacity Reporting Research Skin Small Interfering RNA TLR2 gene TLR3 gene Testing Therapeutic Tissues Untranslated RNA antagonist anti-PD-L1 antibodies autoinflammatory diseases cancer therapy cell type checkpoint therapy clinical care epithelium regeneration gain of function healing improved inhibitor therapy injury recovery insight keratinocyte loss of function neutralizing antibody novel novel therapeutics null mutation organ injury pharmacologic prevent programs receptor regenerative regenerative therapy repaired response response to injury restraint side effect single-cell RNA sequencing skin wound stem cells therapy development wound

项目摘要

Project Summary Abstract The long term objective of the proposed research is to enhance healing after injury that is often slow and incomplete. We hypothesized that injury to epithelial tissue like skin and gut share commonalities in healing, with some native injury responses which actually restrain healing. The goal of this grant is to define the mechanism of this restraint in hopes of developing therapies to enhance healing. We will test if inhibition of these pathways that restrain healing can improve regeneration after injury or infection to the gut or skin in the hopes of suggesting a new class of therapeutics to aid healing from diverse injuries.

项目摘要摘要拟议研究的长期目标是促进创伤后的愈合，通常是缓慢的和不完整。我们假设，皮肤和肠道等上皮组织的损伤在愈合方面有共同之处，有一些天生的伤害反应，实际上抑制了愈合。这笔赠款的目标是定义这种抑制的机制，希望开发治疗方法，以促进愈合。我们将测试是否抑制了这些抑制愈合的途径可以促进肠道或皮肤受伤或感染后的再生。希望提出一种新的治疗方法来帮助从不同的损伤中恢复。