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Mechanism and clinical pilot tst of volar fibroblast to create ectopic volar skin

掌侧成纤维细胞形成异位掌侧皮肤的机制及临床试验

基本信息

批准号：
9322010
负责人：
Luis Andres Garza
金额：
$ 35.82万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-01 至 2019-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9322010
关键词：
3-Dimensional Abdomen Adult Amputees Animal Model Area Autologous Back Biopsy Buttocks Cells Cheek structure Clinical Coculture Techniques Data Dermatologic Dermatology Dose Down-Regulation Ear Epidermis Fibroblasts Frequencies Friction Future Gene Expression Gene Expression Profile Genes Genetic Genetic Transcription Goals Grant Hand Histology Homeobox Genes Human In Vitro Injectable Investigational New Drug Application Irritants Keratin Learning Lip structure Location Longevity Maps Medicine Messenger RNA Minority Monitor Overlapping Genes Pain Phenotype Process Prosthesis Recombinant Proteins Regenerative Medicine Research Resistance Reverse Transcriptase Polymerase Chain Reaction Series Site Skin Small Interfering RNA Stratum corneum Testing Thick Tissues Transfection Up-Regulation experimental study foot human subject in vivo keratinocyte knock-down limb amputation mutant neutralizing antibody non-invasive imaging penis foreskin public health relevance transcription factor volunteer

项目摘要

DESCRIPTION (provided by applicant): The long term objective of the proposed research is to learn how to effectively use cellular therapy in regenerative medicine, especially as pertains to dermatology. In particular, our goal is to convert the identity of skin at the stump site of amputees to thick palmo/plantar (volar) type skin to enhance their use of prosthetics. Towards this clinical goal we first will define the basic genetic control of volar fibroblast skin identity Then we will define homeostatic mechanisms whereby non-volar tissue retains its identity. In so doing, we will optimize conditions for our final effort to use autologous fibroblasts to induce ectopic volar skin in volunteers. We will fully excise this ectopic acral skin as a proof-of-concep trial and a prelude to clinical optimization and use in amputees.

描述（由申请人提供）：拟议研究的长期目标是学习如何有效地在再生医学中使用细胞疗法，特别是与皮肤病学有关的细胞疗法。特别是，我们的目标是将截肢者残肢部位的皮肤转换为厚的掌/跖（掌）型皮肤，以提高他们对假肢的使用。为了实现这一临床目标，我们首先将确定掌侧成纤维细胞皮肤身份的基本遗传控制，然后我们将确定非掌侧组织保持其身份的自我平衡机制。在这样做的过程中，我们将优化条件，我们的最后努力，使用自体成纤维细胞诱导异位掌侧皮肤的志愿者。我们将完全切除这种异位肢端皮肤作为概念验证试验，并作为临床优化和在截肢者中使用的前奏。

项目成果

期刊论文数量（18）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Does prostaglandin D2 hold the cure to male pattern baldness?

DOI：
10.1111/exd.12348
发表时间：
2014-04
期刊：
Experimental dermatology
影响因子：
3.6
作者：
Nieves A;Garza LA
通讯作者：
Garza LA

Improving acne keloidalis nuchae with targeted ultraviolet B treatment: a prospective, randomized, split-scalp comparison study.

DOI：
10.1111/bjd.13119
发表时间：
2014-11
期刊：
The British journal of dermatology
影响因子：
0
作者：
Okoye GA;Rainer BM;Leung SG;Suh HS;Kim JH;Nelson AM;Garza LA;Chien AL;Kang S
通讯作者：
Kang S

Hairy math: addition of Wnt-3a to multiply bulge cells.

毛茸茸的数学：添加 Wnt-3a 来繁殖凸出细胞。