Future Academic Scientists in Dermatology

皮肤科未来的学术科学家

• 批准号: 10663773
• 负责人: Luis Andres Garza
• 金额: $ 18.96万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10663773
• 关键词: Dermatology; Future; Scientist

Project Summary The future of dermatologic research is threatened by the decreasing numbers of MD and MD-PhD Dermatology residents that pursue careers in research and the lack of formal training of PhD basic science skin researchers in translational research. In this application, we propose the Future Academic Scientists in Dermatology (FASID) training program at Johns Hopkins to provide 3 slots for MD and MD-PhD Dermatology residents and PhD post-doctoral fellows to be trained in basic and clinical translational research in investigative dermatology. Each FASID trainee will have the opportunity to be mentored by one of our multidisciplinary R01- or equivalently-funded 13 Primary Faculty Mentors based within or outside of the Dermatology Department. Additional mentorship of the trainees will be provided by a Secondary Faculty Mentor within Dermatology and a 3-person mentorship panel to help ensure progress and a career path towards scientific independence. This FASID program will leverage many outstanding resources at Johns Hopkins, including the Cutaneous Translational Research Program (CTReP) (the Dermatology Department’s clinical trials unit with specific cohorts of patients), the Institute for Clinical and Translational Research (ICTR) (the NIH-funded Clinical and Translational Science Research Award [CTSA]), specific training in clinical research through the School of Public Health (Science of Clinical Investigation (SOCI) and ICTR (Introduction to Clinical Research Course) as well as multiple other institutes, centers and state-of-the-art core facilities. Since the training for Dermatology Residents will extend their residency training from 3 to 4 years, our Department has committed additional salary support in the 4th year to that of a clinical instructor so that there are no financial deterrents to pursuing a career in dermatology research. FASID Trainees will undergo formal core and elective coursework and an enrichment program, which include didactics in clinical research, the responsible conduct of research, grant writing and many aspects of performing clinical and translational research in dermatology. Finally, there will be many opportunities for both the trainees and mentors to evaluate and provide feedback on the progress of the research projects, educational curriculum and the overall training program to permit real-time improvements of the program. Successful implementation of the FASID training program is expected to produce investigators that will become part of the next generation of Dermatology researchers that will be ethnically diverse, and who will enter the workforce with the training in translational research to effectively move basic discoveries to new therapies to help patients suffering from skin diseases.

项目摘要 皮肤病学研究的未来受到MD和MD-PhD数量减少的威胁 皮肤科住院医师从事研究工作，缺乏博士基础科学的正式培训 皮肤研究人员在转化研究。在这个应用程序中，我们提出了未来的学术科学家， 约翰霍普金斯的皮肤病学（FASID）培训计划，为皮肤病学MD和MD-PhD提供3个名额 住院医师和博士博士后研究员将接受基础和临床转化研究的培训， 皮肤科。每个FASID学员都将有机会接受我们多学科R 01- 或同等资助的13名初级教师导师，位于皮肤科内外。 学员的额外指导将由皮肤科的二级导师和 3-个人导师小组，以帮助确保进步和职业道路走向科学独立。这 FASID计划将利用约翰霍普金斯的许多优秀资源，包括皮肤 转化研究计划（CTReP）（皮肤科的临床试验单位， 患者队列），临床和转化研究所（ICTR）（NIH资助的临床和转化研究所） 转化科学研究奖[CTSA]），通过临床研究学院的具体培训， 公共卫生（临床研究科学（SOCI）和ICTR（临床研究课程介绍）， 以及其他多个研究所、中心和最先进的核心设施。自从接受皮肤科培训以来 住院医师将延长他们的住院医师培训从3至4年，我们的部门已承诺额外的 在第四年的工资支持，以一个临床导师，使有没有财政威慑追求 从事皮肤病学研究。FASID学员将接受正式的核心和选修课程， 充实计划，其中包括临床研究教学法，负责任的研究行为，赠款 写作和在皮肤科进行临床和转化研究的许多方面。最后， 学员和导师有很多机会评估并提供有关进展的反馈 研究项目，教育课程和整体培训计划，以允许实时改善 节目FASID培训计划的成功实施预计将产生调查员 这将成为下一代皮肤科研究人员的一部分，他们将是种族多样化的， 将进入劳动力与转化研究的培训，以有效地将基本发现，以新的 帮助皮肤病患者的治疗方法。

项目成果

Crisaborole efficacy in murine models of skin inflammation and Staphylococcus aureus infection.

Crisaborole 在皮肤炎症和金黄色葡萄球菌感染的小鼠模型中的功效。

• DOI: 10.1111/exd.14722
• 发表时间: 2023
• 期刊: Experimental dermatology
• 影响因子: 3.6
• 作者: Youn,Christine;Dikeman,DustinA;Chang,Evelyn;Liu,Haiyun;Nolan,SabrinaJ;Alphonse,MartinP;Joyce,DanielP;Liu,Qi;Meixiong,James;Dong,Xinzhong;Miller,LloydS;Archer,NathanK
• 通讯作者: Archer,NathanK

Bacteria induce skin regeneration via IL-1β signaling.

• DOI: 10.1016/j.chom.2021.03.003
• 发表时间: 2021-05-12
• 期刊: Cell host & microbe
• 影响因子: 30.3
• 作者: Wang G;Sweren E;Liu H;Wier E;Alphonse MP;Chen R;Islam N;Li A;Xue Y;Chen J;Park S;Chen Y;Lee S;Wang Y;Wang S;Archer NK;Andrews W;Kane MA;Dare E;Reddy SK;Hu Z;Grice EA;Miller LS;Garza LA
• 通讯作者: Garza LA

From top to bottom: Staphylococci in atopic dermatitis.

从上到下：特应性皮炎中的葡萄球菌。

• DOI: 10.1016/j.chom.2023.03.014
• 发表时间: 2023
• 期刊: Cell host & microbe
• 影响因子: 30.3
• 作者: Nolan,SabrinaJ;Archer,NathanK
• 通讯作者: Archer,NathanK