Longitudinal Investigation of Fertility and the Environment

生育力与环境的纵向调查

• 批准号: 10928024
• 负责人: Rajeshwari Sundaram
• 金额: $ 24.66万
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10928024
• 关键词: Acute; Adult; Basic Science; Biological Markers; Birth; Blood; Cadmium; Chemicals; Clinical Research; Contraceptive methods; County; Couples; Development; Ensure; Environment; Environmental Impact; Environmental Risk Factor; Fertility; Human; Infant; Infertility; Interview; Investigation; Lead; Length; Life Style; Measures; Mediating; Menstrual cycle; Metals; Michigan; Mission; National Institute of Child Health and Human Development; Parabens; Patient Self-Report; Phenols; Phytoestrogens; Polychlorinated Biphenyls; Pregnancy; Pregnancy loss; Pregnant Women; Process; Psyche structure; Reproduction; Sampling; Seminal fluid; Serum; Standardization; Stress; Texas; Time; Urine; Woman; ambient air pollution; disability; environmental chemical; epidemiology study; lifestyle factors; male; men; organochlorine pollutant; phthalates; pregnant; prospective; recruit; reproductive outcome; saliva sample; time-to-pregnancy

The purpose of the LIFE Study is to assess the impact of environmental factors, broadly defined to include lifestyle factors, on human reproduction and development. The LIFE Study is consistent with the mission of the Eunice Kennedy Shriver National Institute of Child Health and Human Development that includes conducting basic, clinical and epidemiologic research focusing on factors and processes associated with human reproduction and development thereby, ensuring the birth of healthy infants capable of reaching full adult potential unimpaired by physical or mental disabilities. This study is assessing the relation between select environmental factors and human fecundity and fertility, particularly in the context of lifestyle. 501 couples discontinuing contraception for purposes of becoming pregnant were recruited from 16 targeted counties in Michigan and Texas. Couples completed baseline interviews and standardized anthropometric assessments and were prospectively followed for up to 12 months attempting pregnancy. Pregnant women were followed until delivery. Couples provided blood and urine samples at baseline, and men provided semen samples and women saliva samples for the analysis of semen quality and stress biomarkers, respectively. Select blood metals (lead and cadmium), serum organochlorine pollutants (PCBs and PFCs), short lived (e.g.,parabens, phenols, phthalates) chemicals and acute exposure ambient air pollution species were found to be associated with couple fecundity as measured by a longer time required for pregnancy. Male chemical concentrations were observed to be associated with greater reduction in fecundity. Other persistent chemicals such as PFCs were associated with select semen quality endpoints as were other short lived chemicals such as specific phthalates and UV-type BP filters. In a substudy, phytoestrogens were not meaningfully associated with menstrual cycle length but were associated with menstrual regularity among women with self-reported regular cycles (Levine et al. 2020; accepted 2019).

LIFE研究的目的是评估环境因素（广义上包括生活方式因素）对人类生殖和发育的影响。LIFE研究符合尤尼斯·肯尼迪·施莱佛国家儿童健康和人类发展研究所的使命，包括开展基础、临床和流行病学研究，重点关注与人类生殖和发育相关的因素和过程，从而确保健康婴儿的出生能够充分发挥成人潜能，不受身体或精神残疾的影响。 这项研究正在评估选定的环境因素与人类生殖力和生育力之间的关系，特别是在生活方式的背景下。从密歇根州和得克萨斯州的16个目标县招募了501对因怀孕而停止避孕的夫妇。夫妇完成基线访谈和标准化的人体测量评估，并前瞻性地跟踪长达12个月的尝试怀孕。对孕妇进行跟踪直至分娩。夫妇在基线时提供血液和尿液样本，男性提供精液样本，女性提供唾液样本，分别用于精液质量和压力生物标志物的分析。 某些血液金属（铅和镉）、血清有机氯污染物（多氯联苯和全氟化碳）、短寿命（例如，对羟基苯甲酸酯、酚类、邻苯二甲酸酯）化学品和急性暴露于环境空气污染物种被发现与夫妇生育力有关，这是通过怀孕所需的较长时间来衡量的。雄性化学品浓度被认为是与更大的减少生育力。其他持久性化学物质，如全氟化碳与选定的精液质量终点相关，其他短寿命化学物质，如特定的邻苯二甲酸酯和紫外线型BP过滤器。在一项子研究中，植物雌激素与月经周期长度无意义相关，但与自我报告周期规律的女性的月经规律性相关（Levine et al. 2020; accepted 2019）。

项目成果

Urinary Phytoestrogens and Relationship to Menstrual Cycle Length and Variability Among Healthy, Eumenorrheic Women.

健康、月经正常的女性中尿液中的植物雌激素及其与月经周期长度和变异性的关系。

• DOI: 10.1210/jendso/bvz003
• 发表时间: 2020
• 期刊: Journal of the Endocrine Society
• 影响因子: 4.1
• 作者: Levine,LindsayD;Kim,Keewan;Purdue-Smithe,Alexandra;Sundaram,Rajeshwari;Schisterman,EnriqueF;Connell,Matthew;Devilbiss,ElizabethA;Alkhalaf,Zeina;Radoc,JeannieG;BuckLouis,GermaineM;Mumford,SunniL
• 通讯作者: Mumford,SunniL

The prevalence of couple infertility in the United States from a male perspective: evidence from a nationally representative sample.

• DOI: 10.1111/j.2047-2927.2013.00110.x
• 发表时间: 2013-09
• 期刊: Andrology
• 影响因子: 4.5
• 作者: Louis JF;Thoma ME;Sørensen DN;McLain AC;King RB;Sundaram R;Keiding N;Buck Louis GM
• 通讯作者: Buck Louis GM

Low-level environmental metals and metalloids and incident pregnancy loss.

• DOI: 10.1016/j.reprotox.2017.01.011
• 发表时间: 2017-04
• 期刊: Reproductive toxicology (Elmsford, N.Y.)
• 作者: Buck Louis GM;Smarr MM;Sundaram R;Steuerwald AJ;Sapra KJ;Lu Z;Parsons PJ
• 通讯作者: Parsons PJ

Proximity to major roadways and prospectively-measured time-to-pregnancy and infertility.

• DOI: 10.1016/j.scitotenv.2016.10.038
• 发表时间: 2017-01-15
• 期刊: SCIENCE OF THE TOTAL ENVIRONMENT
• 影响因子: 9.8
• 作者: Mendola, Pauline;Sundaram, Rajeshwari;Louis, Germaine M. Buck;Sun, Liping;Wallace, Maeve E.;Smarr, Melissa M.;Sherman, Seth;Zhu, Yeyi;Ying, Qi;Liu, Danping
• 通讯作者: Liu, Danping

Detection of immunoglobulin isotypes from dried blood spots.

• DOI: 10.1016/j.jim.2013.12.001
• 发表时间: 2014-02
• 期刊: Journal of immunological methods
• 影响因子: 2.2
• 作者: Andersen NJ;Mondal TK;Preissler MT;Freed BM;Stockinger S;Bell E;Druschel C;Louis GM;Lawrence DA
• 通讯作者: Lawrence DA