MRI and X-ray catheter design and prototyping

在过去的一年里，我们继续开发与磁共振成像(MRI)兼容的可视设备，以执行计划在MRI下执行的腔内介入程序。 我们一直致力于开发0.55T的临床级MRI导管设备，包括 -有源MRI导丝接收器线圈 -有源核磁共振针头接收线圈 -主动核磁共振心肌活组织检查钳 我们已经发明了几种一流的介入设备，用于新的非手术治疗程序。这些设备包括基于心房导管的三尖瓣修复设备，经下腔静脉进入主动脉使没有良好选择的患者能够进行经导管主动脉瓣置换，非手术的先天性心脏病的非解剖搭桥术，切割二尖瓣和主动脉瓣叶的设备，否则将导致危及生命的心腔或动脉阻塞，挤压心肌的设备来治疗心力衰竭，心脏肌肉切片的设备来治疗不同类型的心力衰竭。其中许多包括新型医疗器械的发明和专利申请，例如用于经下腔静脉进入主动脉的特制闭合装置，用于治疗心肌病的新型壁内植入物，以及用于结构性心脏干预的新型导管工具。 我们还与工业界合作，将我们的实验室发明转化为私营部门的病人护理。我们与一家大型导管公司签订了合作研发协议，与小型导管公司签订了共同开发一些设备的研究协议。我们还赞助了我们内部实验室的小企业创新研究合同，通过小企业将新的高风险技术带入临床测试。

During the past year we have continued our work developing magnetic resonance imaging (MRI) compatible and visible devices to perform endoluminal interventional procedures that are planned to perform under MRI. We have been working to develop clinical-grade MRI catheter devices at 0.55T including - Active MRI guidewire receiver coil - Active MRI needle receiver coil - Active MRI myocardial biopsy forceps We have invented several first-in-class interventional devices for novel therapeutic non-surgical procedures. These include devices for trans-atrial catheter-based tricuspid valve repair, transcaval access to the aorta to enable transcatheter aortic valve replacement in patients with no good options, extra-anatomic bypass for congenital heart disease without surgery, devices to slice mitral and aortic valve leaflets that otherwise would cause life-threatening obstruction of heart chambers or arteries, devices to squeeze the heart muscle to treat heart failure, devices to slice the heart muscle to treat different kinds of heart failure. Many of these include inventions and patent applications for novel medical devices, such as purpose-built closure devices for transcaval access to the aorta, novel intramural implants to treat cardiomyopathy, and novel catheter tools for structural heart interventions. We also work with industry to translate our laboratory inventions into the private sector for patient care. We have entered into collaborative research and development agreements with a large catheter company, research agreements with small catheter company to co-develop some devices. We also have sponsored Small Business Innovation Research contracts from our intramural laboratory to shepherd novel high-risk technology through small businesses into clinical testing.