MRI and X-ray catheter design and prototyping

MRI 和 X 射线导管设计和原型制作

• 批准号: 10929117
• 负责人: Robert J Lederman
• 金额: $ 92.17万
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10929117
• 关键词: Agreement; Anatomy; Aorta; Arteries; Blood Vessels; Businesses; Bypass; Cardiac; Cardiac Catheterization Procedures; Cardiomyopathies; Catheters; Childhood; Clinical; Devices; Diagnostic; Forcep; Goals; Heart; Heart Atrium; Heart failure; Heating; Implant; Industry; Intervention; Laboratories; Legal patent; Life; Magnetic Resonance Imaging; Medical Device; Mitral Valve; Mitral Valve Insufficiency; Myocardium; Needles; Obstruction; Operative Surgical Procedures; Orphan; Patient Care; Patients; Private Sector; Procedures; Protocols documentation; Research; Research Contracts; Roentgen Rays; Safety; Shunt Device; Slice; Small Business Innovation Research Grant; Structure; Technology; Testing; Therapeutic; Translating; Tricuspid Valve Insufficiency; Tricuspid valve structure; Ventricular Septal Defects; Work; aortic valve; aortic valve replacement; congenital heart disorder; design; high risk; improved; invention; myocardial biopsy; nitinol; novel; novel therapeutics; prototype; radio frequency; repaired; research and development; research clinical testing; tool

During the past year we have continued our work developing magnetic resonance imaging (MRI) compatible and visible devices to perform endoluminal interventional procedures that are planned to perform under MRI. We have been working to develop clinical-grade MRI catheter devices at 0.55T including - Active MRI guidewire receiver coil - Active MRI needle receiver coil - Active MRI myocardial biopsy forceps We have invented several first-in-class interventional devices for novel therapeutic non-surgical procedures. These include devices for trans-atrial catheter-based tricuspid valve repair, transcaval access to the aorta to enable transcatheter aortic valve replacement in patients with no good options, extra-anatomic bypass for congenital heart disease without surgery, devices to slice mitral and aortic valve leaflets that otherwise would cause life-threatening obstruction of heart chambers or arteries, devices to squeeze the heart muscle to treat heart failure, devices to slice the heart muscle to treat different kinds of heart failure. Many of these include inventions and patent applications for novel medical devices, such as purpose-built closure devices for transcaval access to the aorta, novel intramural implants to treat cardiomyopathy, and novel catheter tools for structural heart interventions. We also work with industry to translate our laboratory inventions into the private sector for patient care. We have entered into collaborative research and development agreements with a large catheter company, research agreements with small catheter company to co-develop some devices. We also have sponsored Small Business Innovation Research contracts from our intramural laboratory to shepherd novel high-risk technology through small businesses into clinical testing.

在过去的一年中，我们继续致力于开发磁共振成像（MRI）兼容和可视设备，以执行计划在MRI下执行的腔内介入手术。 我们一直致力于开发0.55T的临床级MRI导管设备，包括 - 有源MRI导丝接收器线圈 - 有源MRI针接收器线圈 - 主动式MRI心肌活检钳 我们已经发明了几种一流的介入器械，用于新型治疗性非外科手术。 这些包括用于基于经心房导管的三尖瓣修复的装置，经腔静脉进入主动脉以使没有良好选择的患者能够进行经导管主动脉瓣置换术，用于先天性心脏病而无需手术的解剖外旁路，用于切割二尖瓣和主动脉瓣叶的装置，否则会导致危及生命的心腔或动脉阻塞，挤压心肌以治疗心力衰竭的装置，切割心肌的设备来治疗各种心力衰竭。 其中许多包括新型医疗器械的发明和专利申请，例如用于经腔静脉进入主动脉的专用闭合器械，治疗心肌病的新型壁内植入物，以及用于结构性心脏介入的新型导管工具。 我们还与行业合作，将我们的实验室发明转化为私营部门的病人护理。 我们与一家大型导管公司签订了合作研发协议，与小型导管公司签订了研究协议，共同开发一些设备。 我们还赞助了我们内部实验室的小企业创新研究合同，以指导新的高风险技术通过小企业进入临床测试。