MRI and X-ray catheter design and prototyping

MRI 和 X 射线导管设计和原型制作

• 批准号: 10929117
• 负责人: Robert J Lederman
• 金额: $ 92.17万
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10929117
• 关键词: Agreement; Anatomy; Aorta; Arteries; Blood Vessels; Businesses; Bypass; Cardiac; Cardiac Catheterization Procedures; Cardiomyopathies; Catheters; Childhood; Clinical; Devices; Diagnostic; Forcep; Goals; Heart; Heart Atrium; Heart failure; Heating; Implant; Industry; Intervention; Laboratories; Legal patent; Life; Magnetic Resonance Imaging; Medical Device; Mitral Valve; Mitral Valve Insufficiency; Myocardium; Needles; Obstruction; Operative Surgical Procedures; Orphan; Patient Care; Patients; Private Sector; Procedures; Protocols documentation; Research; Research Contracts; Roentgen Rays; Safety; Shunt Device; Slice; Small Business Innovation Research Grant; Structure; Technology; Testing; Therapeutic; Translating; Tricuspid Valve Insufficiency; Tricuspid valve structure; Ventricular Septal Defects; Work; aortic valve; aortic valve replacement; congenital heart disorder; design; high risk; improved; invention; myocardial biopsy; nitinol; novel; novel therapeutics; prototype; radio frequency; repaired; research and development; research clinical testing; tool

During the past year we have continued our work developing magnetic resonance imaging (MRI) compatible and visible devices to perform endoluminal interventional procedures that are planned to perform under MRI. We have been working to develop clinical-grade MRI catheter devices at 0.55T including - Active MRI guidewire receiver coil - Active MRI needle receiver coil - Active MRI myocardial biopsy forceps We have invented several first-in-class interventional devices for novel therapeutic non-surgical procedures. These include devices for trans-atrial catheter-based tricuspid valve repair, transcaval access to the aorta to enable transcatheter aortic valve replacement in patients with no good options, extra-anatomic bypass for congenital heart disease without surgery, devices to slice mitral and aortic valve leaflets that otherwise would cause life-threatening obstruction of heart chambers or arteries, devices to squeeze the heart muscle to treat heart failure, devices to slice the heart muscle to treat different kinds of heart failure. Many of these include inventions and patent applications for novel medical devices, such as purpose-built closure devices for transcaval access to the aorta, novel intramural implants to treat cardiomyopathy, and novel catheter tools for structural heart interventions. We also work with industry to translate our laboratory inventions into the private sector for patient care. We have entered into collaborative research and development agreements with a large catheter company, research agreements with small catheter company to co-develop some devices. We also have sponsored Small Business Innovation Research contracts from our intramural laboratory to shepherd novel high-risk technology through small businesses into clinical testing.

在过去的一年里，我们继续致力于开发磁共振成像（MRI）兼容和可见设备，以执行计划在MRI下执行的腔内介入手术。