Real-time MRI guided cardiovascular intervention
实时 MRI 引导心血管干预
基本信息
- 批准号:8557942
- 负责人:
- 金额:$ 121.14万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:AdultAortaBiologicalBioprosthesis deviceCardiacCardiac Surgery proceduresCardiologyCardiovascular systemCatheterizationChest wall structureChildChildhoodCicatrixComplexCongenital Heart DefectsCustomDevelopmentDevicesDiagnostic radiologic examinationEnvironmentFamily suidaeHealedHeartHumanImplantInterventionLeft ventricular structureMagnetic Resonance ImagingMechanicsNational Heart, Lung, and Blood InstituteOperative Surgical ProceduresPatientsPericardial body locationPericardiocentesisPeripheral arterial diseaseProceduresPulmonary Artery CatheterizationPulmonary artery structureRadiationReportingResearchResearch PersonnelRight ventricular structureRoentgen RaysStentsSystemTestingTimeVentricular septumWorkclinical applicationcongenital heart disorderhealingimplantationmitral valve replacementnovelnovel strategiespressurerepairedtool
项目摘要
During the past year we have continued our work applying rapid MRI to guide simple and complex mechanical and biological interventions.
We reported the first careful comparison of conventional X-ray and wholly MRI guided transfemoral pulmonary artery catheterization in adults. In this pilot, we found that radiation-free MRI catheterization is safe and feasible. Guidewire-free MRI catheterization was just as successful as X-ray catheterization (more so in specific challenging procedure steps) and took approximately the same time. We continue to perform X-ray-free MRI catheterization in patients whenever possible.
We performed the first ever MRI pericardiocentesis procedure in humans.
We have developed still another novel access port into the heart across the chest wall, as an alternative to surgery to implant large cardiac appliances such as mitral valve replacements. In this novel approach, we enter the left ventricle across the interventricular septum. This allows the dangerous port to pericardial space to enjoy low pressure, and the right ventricle to serve as the high-pressure pop-off chamber. We found unexpectedly that the interventricular septum closes tightly, immediately, and heals spontaneously as a very small scar. We intend these also to allow direct repair of congenital heart defects on small children who otherwise might require open surgical access.
We have begun work on challenges in pediatric cardiology, starting with a non-surgical pulmonary artery resistor device to help reduce the complexity of cardiac surgery for certain congenital heart defects.
We are developing other novel catheterization tools, for example, to access the aorta without surgery in patients with severe peripheral artery disease.
NHLBI Cardiothoracic Surgery Research Branch investigators have used our interventional MRI system and environment to further test the feasibility and utility of real-time MRI guidance for surgical transapical implantation of a custom aortic stent valve bioprosthesis in swine.
Overall we have successfully developed novel applications of real-time MRI for cardiovascular treatments, and we continue to work to clinical applications of these exciting new developments.
在过去的一年里,我们继续应用快速MRI来指导简单和复杂的机械和生物干预。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Robert J Lederman其他文献
Lithography based resonant marker design for MRI catheter visualization
- DOI:
10.1186/1532-429x-18-s1-p208 - 发表时间:
2016-01-27 - 期刊:
- 影响因子:
- 作者:
Engin Baysoy;Dursun K Yildirim;Cagla Ozsoy;Adrienne C Washburn;Anthony Z Faranesh;Senol Mutlu;Robert J Lederman;Ozgur Kocaturk - 通讯作者:
Ozgur Kocaturk
Spiral imaging with off-resonance reconstruction for MRI-guided cardiovascular catheterizations using commercial off-the-shelf nitinol guidewires
- DOI:
10.1186/1532-429x-18-s1-p216 - 发表时间:
2016-01-27 - 期刊:
- 影响因子:
- 作者:
Adrienne E Campbell-Washburn;Toby Rogers;Kanishka Ratnayaka;Burcu Basar;Ozgur Kocaturk;Hui Xue;Robert J Lederman;Michael S Hansen;Anthony Z Faranesh - 通讯作者:
Anthony Z Faranesh
MRI compatible hemodynamic recording system
- DOI:
10.1186/1532-429x-15-s1-p22 - 发表时间:
2013-01-30 - 期刊:
- 影响因子:
- 作者:
Bo Xiao;John W Kakareka;Randall H Pursley;Thomas Pohida;Robert J Lederman;Anthony Faranesh - 通讯作者:
Anthony Faranesh
Positive contrast spiral imaging of a nitinol guidewire
- DOI:
10.1186/1532-429x-17-s1-q15 - 发表时间:
2015-02-03 - 期刊:
- 影响因子:
- 作者:
Adrienne E Campbell-Washburn;Toby Rogers;Burcu Basar;Merdim Sonmez;Ozgur Kocaturk;Robert J Lederman;Michael Hansen;Anthony Z Faranesh - 通讯作者:
Anthony Z Faranesh
Technologist primer for MRI right heart catheterization: the NIH and CNMC experience
- DOI:
10.1186/1532-429x-16-s1-t1 - 发表时间:
2014-01-16 - 期刊:
- 影响因子:
- 作者:
Jonathan R Mazal;Kendall O'Brien;William Schenke;Annette Stine;Laurie Grant;Anthony Z Faranesh;Kanishka Ratnayaka;Robert J Lederman - 通讯作者:
Robert J Lederman
Robert J Lederman的其他文献
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{{ truncateString('Robert J Lederman', 18)}}的其他基金
Diagnostic and interventional cardiovascular catheterization
诊断和介入心血管导管插入术
- 批准号:
8940179 - 财政年份:
- 资助金额:
$ 121.14万 - 项目类别:
Biological and mechanical therapies enabled by cardiovascular interventional MRI
心血管介入 MRI 实现生物和机械治疗
- 批准号:
7594421 - 财政年份:
- 资助金额:
$ 121.14万 - 项目类别:
MRI and X-ray catheter design and prototyping
MRI 和 X 射线导管设计和原型制作
- 批准号:
10929117 - 财政年份:
- 资助金额:
$ 121.14万 - 项目类别:
Diagnostic and interventional cardiovascular catheterization
诊断和介入心血管导管插入术
- 批准号:
9353171 - 财政年份:
- 资助金额:
$ 121.14万 - 项目类别:
Biological and mechanical therapies enabled by cardiovas
心血管支持的生物和机械疗法
- 批准号:
7321629 - 财政年份:
- 资助金额:
$ 121.14万 - 项目类别:
Biological and mechanical therapies enabled by cardiovas
心血管支持的生物和机械疗法
- 批准号:
6822883 - 财政年份:
- 资助金额:
$ 121.14万 - 项目类别:
Real-time cardiovascular MRI and co-registration technical development
实时心血管MRI及联合配准技术开发
- 批准号:
8557994 - 财政年份:
- 资助金额:
$ 121.14万 - 项目类别:
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