Real-time MRI guided cardiovascular intervention

实时 MRI 引导心血管干预

基本信息

项目摘要

During the past year we have continued our work applying rapid MRI to guide simple and complex mechanical and biological interventions. We reported the first careful comparison of conventional X-ray and wholly MRI guided transfemoral pulmonary artery catheterization in adults. In this pilot, we found that radiation-free MRI catheterization is safe and feasible. Guidewire-free MRI catheterization was just as successful as X-ray catheterization (more so in specific challenging procedure steps) and took approximately the same time. We continue to perform X-ray-free MRI catheterization in patients whenever possible. We performed the first ever MRI pericardiocentesis procedure in humans. We have developed still another novel access port into the heart across the chest wall, as an alternative to surgery to implant large cardiac appliances such as mitral valve replacements. In this novel approach, we enter the left ventricle across the interventricular septum. This allows the dangerous port to pericardial space to enjoy low pressure, and the right ventricle to serve as the high-pressure pop-off chamber. We found unexpectedly that the interventricular septum closes tightly, immediately, and heals spontaneously as a very small scar. We intend these also to allow direct repair of congenital heart defects on small children who otherwise might require open surgical access. We have begun work on challenges in pediatric cardiology, starting with a non-surgical pulmonary artery resistor device to help reduce the complexity of cardiac surgery for certain congenital heart defects. We are developing other novel catheterization tools, for example, to access the aorta without surgery in patients with severe peripheral artery disease. NHLBI Cardiothoracic Surgery Research Branch investigators have used our interventional MRI system and environment to further test the feasibility and utility of real-time MRI guidance for surgical transapical implantation of a custom aortic stent valve bioprosthesis in swine. Overall we have successfully developed novel applications of real-time MRI for cardiovascular treatments, and we continue to work to clinical applications of these exciting new developments.
在过去的一年中,我们继续应用快速MRI指导简单和复杂的机械和生物干预。 我们报告了第一次在成人中仔细比较常规X线和完全MRI引导下经股动脉肺动脉导管插入术。 在本试验中,我们发现无辐射MRI导管插入术是安全可行的。 无导丝MRI导管插入术与X线导管插入术一样成功(在特定的挑战性手术步骤中更是如此),所用时间大致相同。 我们继续尽可能对患者进行无X射线MRI导管插入术。 我们进行了人类第一次MRI心包穿刺术。 我们还开发了另一种穿过胸壁进入心脏的新型入路端口,作为植入大型心脏器械(如二尖瓣置换术)的手术的替代方案。 在这种新的方法中,我们穿过室间隔进入左心室。 这使得心包腔的危险端口能够享受低压,而右心室则充当高压弹出室。 我们意外地发现,室间隔立即紧密闭合,并作为一个非常小的疤痕自发愈合。 我们还打算直接修复可能需要开放手术入路的幼儿先天性心脏病。 我们已经开始致力于儿科心脏病学的挑战,从非手术肺动脉阻力装置开始,以帮助降低某些先天性心脏病心脏手术的复杂性。 我们正在开发其他新的导管插入工具,例如,在患有严重外周动脉疾病的患者中,无需手术即可进入主动脉。 NHLBI心胸外科研究分支研究者使用我们的介入MRI系统和环境进一步测试实时MRI引导在猪体内经心尖植入定制主动脉支架瓣膜生物假体的可行性和实用性。 总的来说,我们已经成功地开发了实时MRI在心血管治疗中的新应用,我们将继续致力于这些令人兴奋的新发展的临床应用。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Robert J Lederman其他文献

Lithography based resonant marker design for MRI catheter visualization
  • DOI:
    10.1186/1532-429x-18-s1-p208
  • 发表时间:
    2016-01-27
  • 期刊:
  • 影响因子:
  • 作者:
    Engin Baysoy;Dursun K Yildirim;Cagla Ozsoy;Adrienne C Washburn;Anthony Z Faranesh;Senol Mutlu;Robert J Lederman;Ozgur Kocaturk
  • 通讯作者:
    Ozgur Kocaturk
Spiral imaging with off-resonance reconstruction for MRI-guided cardiovascular catheterizations using commercial off-the-shelf nitinol guidewires
  • DOI:
    10.1186/1532-429x-18-s1-p216
  • 发表时间:
    2016-01-27
  • 期刊:
  • 影响因子:
  • 作者:
    Adrienne E Campbell-Washburn;Toby Rogers;Kanishka Ratnayaka;Burcu Basar;Ozgur Kocaturk;Hui Xue;Robert J Lederman;Michael S Hansen;Anthony Z Faranesh
  • 通讯作者:
    Anthony Z Faranesh
MRI compatible hemodynamic recording system
  • DOI:
    10.1186/1532-429x-15-s1-p22
  • 发表时间:
    2013-01-30
  • 期刊:
  • 影响因子:
  • 作者:
    Bo Xiao;John W Kakareka;Randall H Pursley;Thomas Pohida;Robert J Lederman;Anthony Faranesh
  • 通讯作者:
    Anthony Faranesh
Positive contrast spiral imaging of a nitinol guidewire
  • DOI:
    10.1186/1532-429x-17-s1-q15
  • 发表时间:
    2015-02-03
  • 期刊:
  • 影响因子:
  • 作者:
    Adrienne E Campbell-Washburn;Toby Rogers;Burcu Basar;Merdim Sonmez;Ozgur Kocaturk;Robert J Lederman;Michael Hansen;Anthony Z Faranesh
  • 通讯作者:
    Anthony Z Faranesh
Technologist primer for MRI right heart catheterization: the NIH and CNMC experience
  • DOI:
    10.1186/1532-429x-16-s1-t1
  • 发表时间:
    2014-01-16
  • 期刊:
  • 影响因子:
  • 作者:
    Jonathan R Mazal;Kendall O'Brien;William Schenke;Annette Stine;Laurie Grant;Anthony Z Faranesh;Kanishka Ratnayaka;Robert J Lederman
  • 通讯作者:
    Robert J Lederman

Robert J Lederman的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Robert J Lederman', 18)}}的其他基金

Diagnostic and interventional cardiovascular catheterization
诊断和介入心血管导管插入术
  • 批准号:
    8940179
  • 财政年份:
  • 资助金额:
    $ 121.14万
  • 项目类别:
Real-time MRI guided cardiovascular intervention
实时 MRI 引导心血管干预
  • 批准号:
    8939792
  • 财政年份:
  • 资助金额:
    $ 121.14万
  • 项目类别:
Biological and mechanical therapies enabled by cardiovascular interventional MRI
心血管介入 MRI 实现生物和机械治疗
  • 批准号:
    7594421
  • 财政年份:
  • 资助金额:
    $ 121.14万
  • 项目类别:
MRI and X-ray catheter design and prototyping
MRI 和 X 射线导管设计和原型制作
  • 批准号:
    10929117
  • 财政年份:
  • 资助金额:
    $ 121.14万
  • 项目类别:
Diagnostic and interventional cardiovascular catheterization
诊断和介入心血管导管插入术
  • 批准号:
    9353171
  • 财政年份:
  • 资助金额:
    $ 121.14万
  • 项目类别:
Biological and mechanical therapies enabled by cardiovas
心血管支持的生物和机械疗法
  • 批准号:
    6822883
  • 财政年份:
  • 资助金额:
    $ 121.14万
  • 项目类别:
Biological and mechanical therapies enabled by cardiovas
心血管支持的生物和机械疗法
  • 批准号:
    7321629
  • 财政年份:
  • 资助金额:
    $ 121.14万
  • 项目类别:
MRI catheter design and fabrication
MRI 导管设计和制造
  • 批准号:
    8746879
  • 财政年份:
  • 资助金额:
    $ 121.14万
  • 项目类别:
MRI catheter design and fabrication
MRI 导管设计和制造
  • 批准号:
    8344989
  • 财政年份:
  • 资助金额:
    $ 121.14万
  • 项目类别:
Real-time cardiovascular MRI and co-registration technical development
实时心血管MRI及联合配准技术开发
  • 批准号:
    8557994
  • 财政年份:
  • 资助金额:
    $ 121.14万
  • 项目类别:

相似海外基金

Deep learning to enable the genetic analysis of aorta
深度学习可实现主动脉的遗传分析
  • 批准号:
    10807379
  • 财政年份:
    2023
  • 资助金额:
    $ 121.14万
  • 项目类别:
Clinical benefits and mechanism of action of angiotensin-II receptor blocker on Cardiovascular remodeling in patients with repaired coarctation of aorta
血管紧张素II受体阻滞剂对主动脉缩窄修复患者心血管重塑的临床疗效及作用机制
  • 批准号:
    10734120
  • 财政年份:
    2023
  • 资助金额:
    $ 121.14万
  • 项目类别:
Development of new preventive method for postoperative paraplegia of thoracoabdominal aorta using exosomes
利用外泌体开发胸腹主动脉术后截瘫的新预防方法
  • 批准号:
    22K08940
  • 财政年份:
    2022
  • 资助金额:
    $ 121.14万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
CAREER: Hemodynamic Mechanisms of Heart-Aorta-Brain Coupling with An Integrated Preventive Medicine Education Program for Socioeconomically Disadvantaged Groups
职业:心-主动脉-脑耦合的血流动力学机制以及针对社会经济弱势群体的综合预防医学教育计划
  • 批准号:
    2145890
  • 财政年份:
    2022
  • 资助金额:
    $ 121.14万
  • 项目类别:
    Continuing Grant
Dissecting the role of hemodynamics in ascending aorta aneurysm development in bicuspid aortic valve disease
剖析血流动力学在二叶式主动脉瓣疾病升主动脉瘤发展中的作用
  • 批准号:
    500274
  • 财政年份:
    2022
  • 资助金额:
    $ 121.14万
  • 项目类别:
    Studentship Programs
Smooth muscle cell diversity and thoracic aorta vulnerability
平滑肌细胞多样性和胸主动脉脆弱性
  • 批准号:
    453372
  • 财政年份:
    2021
  • 资助金额:
    $ 121.14万
  • 项目类别:
    Operating Grants
Deep learning to enable the genetic analysis of aorta
深度学习可实现主动脉的遗传分析
  • 批准号:
    10613402
  • 财政年份:
    2021
  • 资助金额:
    $ 121.14万
  • 项目类别:
Determinants of Aorta Heterogeneity
主动脉异质性的决定因素
  • 批准号:
    10359801
  • 财政年份:
    2021
  • 资助金额:
    $ 121.14万
  • 项目类别:
Determinants of Aorta Heterogeneity
主动脉异质性的决定因素
  • 批准号:
    10618144
  • 财政年份:
    2021
  • 资助金额:
    $ 121.14万
  • 项目类别:
Development of bifurcated curved bio-tube for the aorta with in-body tissue architecture
开发具有体内组织结构的主动脉分叉弯曲生物管
  • 批准号:
    21H03819
  • 财政年份:
    2021
  • 资助金额:
    $ 121.14万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了