MRI catheter design and fabrication

MRI 导管设计和制造

• 批准号: 8344989
• 负责人: Robert J Lederman
• 金额: $ 80.79万
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8344989
• 关键词: Anatomy; Arteries; Bypass; Catheters; Chronic; Clinical; Development; Devices; Frequencies; Goals; Heart Diseases; Heating; Imaging Device; Imaging Techniques; Implant; Location; Magnetic Resonance Imaging; Mechanics; Mitral Valve Insufficiency; National Heart, Lung, and Blood Institute; Needles; Patients; Peripheral; Polymers; Procedures; Property; Protocols documentation; Radio; Safety; Shunt Device; Solutions; System; Testing; Time; Transjugular intrahepatic portosystemic shunt procedure; Ventricular Septal Defects; Work; base; design; improved; nitinol; novel; repaired; safety testing; tool

During the past year we have continued our work developing magnetic resonance imaging (MRI) compatible and visible devices to perform endoluminal interventional procedures that are planned to perform under MRI. We have developed first MRI compatible guidewire that provides both tip and shaft visibility under MRI at the same time. We have also developed the first polymer catheter shaft that can be visualized during the procedure without effecting its mechanical properties. We are developing clinical-grade catheter and compatible guidewire system to perform simple endoluminal interventional procedures in peripheral arteries to recanalize chronic total occlusion of peripheral arteries. We are developing MRI compatible and visible active needle to perform Transjugular Intrahepatic Portosystemic Shunt (TIPS) procedure under MRI. We are also improving our catheter-based solution to treat functional mitral valve regurgitation. We are beginning development of clinical grade tools using MRI compatible materials to perform these investigational procedures in patients. We continue to develop nitinol based implants like extra anatomic bypass shunt and resonant staple. We also continue to develop deflectable active guiding catheter that is required to deliver these implants to target anatomical location. We continue to work on radio frequency heating safety tests of interventional MRI devices. We currently work on to develop a new general protocole to test heating safety of active intravascular devices during real time MRI procedures.

在过去的一年里，我们继续开发与磁共振成像(MRI)兼容的可视设备，以执行计划在MRI下执行的腔内介入程序。我们已经开发了第一个与MRI兼容的导丝，可以同时在MRI下提供顶端和竖直的可见性。我们还开发了第一个聚合物导管轴，可以在不影响其机械性能的情况下在手术过程中可视化。 我们正在开发临床级别的导管和兼容的导丝系统，以执行简单的外周动脉腔内介入操作，以再通外周动脉的慢性完全闭塞。 我们正在开发与MRI兼容的、可见的有源针，以便在MRI下进行经颈静脉肝内门体分流术(TIPS)。我们还在改进我们基于导管的解决方案，以治疗功能性二尖瓣反流。我们正在开始开发临床分级工具，使用与MRI兼容的材料在患者身上执行这些研究程序。 我们继续开发基于镍钛醇的植入物，如额外的解剖旁路分流和共振式吻合器。我们还在继续开发可偏转的主动引导导管，以将这些植入物输送到目标解剖位置。 我们继续致力于介入性核磁共振设备的射频加热安全测试。我们目前致力于开发一种新的通用协议，以测试实时MRI过程中主动血管内设备的加热安全性。