MRI catheter design and fabrication

MRI 导管设计和制造

• 批准号: 8344989
• 负责人: Robert J Lederman
• 金额: $ 80.79万
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8344989
• 关键词: Anatomy; Arteries; Bypass; Catheters; Chronic; Clinical; Development; Devices; Frequencies; Goals; Heart Diseases; Heating; Imaging Device; Imaging Techniques; Implant; Location; Magnetic Resonance Imaging; Mechanics; Mitral Valve Insufficiency; National Heart, Lung, and Blood Institute; Needles; Patients; Peripheral; Polymers; Procedures; Property; Protocols documentation; Radio; Safety; Shunt Device; Solutions; System; Testing; Time; Transjugular intrahepatic portosystemic shunt procedure; Ventricular Septal Defects; Work; base; design; improved; nitinol; novel; repaired; safety testing; tool

During the past year we have continued our work developing magnetic resonance imaging (MRI) compatible and visible devices to perform endoluminal interventional procedures that are planned to perform under MRI. We have developed first MRI compatible guidewire that provides both tip and shaft visibility under MRI at the same time. We have also developed the first polymer catheter shaft that can be visualized during the procedure without effecting its mechanical properties. We are developing clinical-grade catheter and compatible guidewire system to perform simple endoluminal interventional procedures in peripheral arteries to recanalize chronic total occlusion of peripheral arteries. We are developing MRI compatible and visible active needle to perform Transjugular Intrahepatic Portosystemic Shunt (TIPS) procedure under MRI. We are also improving our catheter-based solution to treat functional mitral valve regurgitation. We are beginning development of clinical grade tools using MRI compatible materials to perform these investigational procedures in patients. We continue to develop nitinol based implants like extra anatomic bypass shunt and resonant staple. We also continue to develop deflectable active guiding catheter that is required to deliver these implants to target anatomical location. We continue to work on radio frequency heating safety tests of interventional MRI devices. We currently work on to develop a new general protocole to test heating safety of active intravascular devices during real time MRI procedures.

在过去的一年中，我们继续开发磁共振成像（MRI）兼容和可见设备，以执行计划在MRI下执行的内部介入介入程序。我们已经开发了第一个MRI兼容指南，可同时提供MRI下的尖端和轴可见性。我们还开发了第一个聚合物导管轴，该轴可以在过程中可视化，而不会影响其机械性能。 我们正在开发临床级导管和兼容的导丝系统，以在外周动脉中执行简单的内胚式介入手术，以重新弥补周围动脉的慢性总闭塞。 我们正在开发MRI兼容且可见的活性针，以执行MRI下的经宫内肝内门体分流（TIPS）程序。我们还正在改善基于导管的解决方案，以治疗功能性二尖瓣反流。我们正在使用MRI兼容材料开始开发临床级工具，以在患者中执行这些研究程序。 我们继续开发基于硝基氨基的植入物，例如额外的解剖旁路分流器和共振剂。我们还继续开发可偏转的主动引导导管，这些导管将这些植入物运送到靶向解剖位置所需。 我们继续研究介入MRI设备的射频加热安全测试。目前，我们正在努力开发一种新的通用原核，以实时MRI程序测试活性血管内设备的加热安全性。