MRI catheter design and fabrication

MRI 导管设计和制造

• 批准号: 8344989
• 负责人: Robert J Lederman
• 金额: $ 80.79万
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8344989
• 关键词: Anatomy; Arteries; Bypass; Catheters; Chronic; Clinical; Development; Devices; Frequencies; Goals; Heart Diseases; Heating; Imaging Device; Imaging Techniques; Implant; Location; Magnetic Resonance Imaging; Mechanics; Mitral Valve Insufficiency; National Heart, Lung, and Blood Institute; Needles; Patients; Peripheral; Polymers; Procedures; Property; Protocols documentation; Radio; Safety; Shunt Device; Solutions; System; Testing; Time; Transjugular intrahepatic portosystemic shunt procedure; Ventricular Septal Defects; Work; base; design; improved; nitinol; novel; repaired; safety testing; tool

During the past year we have continued our work developing magnetic resonance imaging (MRI) compatible and visible devices to perform endoluminal interventional procedures that are planned to perform under MRI. We have developed first MRI compatible guidewire that provides both tip and shaft visibility under MRI at the same time. We have also developed the first polymer catheter shaft that can be visualized during the procedure without effecting its mechanical properties. We are developing clinical-grade catheter and compatible guidewire system to perform simple endoluminal interventional procedures in peripheral arteries to recanalize chronic total occlusion of peripheral arteries. We are developing MRI compatible and visible active needle to perform Transjugular Intrahepatic Portosystemic Shunt (TIPS) procedure under MRI. We are also improving our catheter-based solution to treat functional mitral valve regurgitation. We are beginning development of clinical grade tools using MRI compatible materials to perform these investigational procedures in patients. We continue to develop nitinol based implants like extra anatomic bypass shunt and resonant staple. We also continue to develop deflectable active guiding catheter that is required to deliver these implants to target anatomical location. We continue to work on radio frequency heating safety tests of interventional MRI devices. We currently work on to develop a new general protocole to test heating safety of active intravascular devices during real time MRI procedures.

在过去的一年中，我们继续致力于开发磁共振成像（MRI）兼容和可视设备，以执行计划在MRI下执行的腔内介入手术。我们开发了第一种MRI兼容导丝，可同时在MRI下提供头端和管身可见性。我们还开发了第一个聚合物导管轴，可以在手术过程中可视化，而不会影响其机械性能。 我们正在开发临床级导管和兼容的导丝系统，用于在外周动脉中进行简单的腔内介入手术，以再通慢性完全闭塞的外周动脉。 我们正在开发与MRI兼容的可视活动针，用于在MRI下进行经颈静脉肝内门体分流术（TIPS）。我们还在改进基于导管的解决方案，以治疗功能性二尖瓣返流。我们正在开始开发使用MRI兼容材料的临床级工具，以在患者中执行这些研究程序。 我们继续开发基于镍钛合金的植入物，如额外解剖旁路分流和共振吻合钉。我们还继续开发将这些植入物输送到目标解剖位置所需的可偏转主动导引导管。 我们继续开展介入性MRI器械的射频致热安全性测试。我们目前正致力于开发一种新的通用方案，以测试有源血管内器械在真实的时间MRI程序中的致热安全性。