Real-time MRI guided cardiovascular intervention

实时 MRI 引导心血管干预

基本信息

项目摘要

During the past year we have continued our work applying rapid MRI to guide simple and complex mechanical and biological interventions. We have introduced MRI catheterization into standard clinical practice at the NIH clinical center, based on our earlier careful pilot research comparison of conventional X-ray and wholly MRI guided transfemoral pulmonary artery catheterization in adults. We continue to enhance the capabilities of MRI catheterization to characterize heart function in patients. We continue to test MRI pericardiocentesis procedure in humans. We are developing new approaches to connect different heart chambers without surgery in patients with congenital heart disease. We also continue work towards direct repair of congenital heart defects on small children who otherwise might require open surgical access. We have completed a strategic project to accomplish non-surgical extra-anatomic bypass (a bidirectional Glenn superior cavo-pulmonary shunt) in animals, and expect to be able to translate this into the care of children in upcoming years. We are developing other novel catheterization tools, for example, to access the aorta without surgery in patients with small leg arteries (especially women) and patients with severe peripheral artery disease. This key advance has been translated into over 40 patients in its first year of clinical adoption at multiple sites across the United States, where it has proven lifesaving in many cases. We have now begun to sponsor a multi-center trial of this transcaval approach to transcatheter aortic valve replacement in patients without other good options. Simultaneously we are developing a purpose-built closure device for these caval-aortic access ports. We are helping other US medical centers develop their own interventional MRI programs. Overall we have successfully developed novel applications of real-time MRI for cardiovascular treatments, and we continue to work to clinical applications of these exciting new developments.
在过去的一年里,我们继续应用快速 MRI 来指导简单和复杂的机械和生物干预。 基于我们早期对成人常规 X 射线和全 MRI 引导经股肺动脉插管术的仔细试点研究比较,我们已将 MRI 插管术引入 NIH 临床中心的标准临床实践。 我们不断增强 MRI 导管插入术表征患者心脏功能的能力。 我们继续在人体中测试 MRI 心包穿刺术。 我们正在开发新方法,无需手术即可连接先天性心脏病患者的不同心室。我们还继续努力直接修复可能需要开放手术的幼儿先天性心脏缺陷。 我们已经完成了一个战略项目,以在动物身上实现非手术解剖外搭桥(双向格伦上腔静脉肺分流术),并期望能够在未来几年将其转化为儿童的护理。 我们正在开发其他新型导管插入工具,例如,无需手术即可进入小腿动脉患者(尤其是女性)和患有严重外周动脉疾病的患者的主动脉。 这一关键进步在美国多个地点进行临床应用的第一年就已转化为 40 多名患者,事实证明它在许多情况下可以挽救生命。 我们现在已经开始赞助一项多中心试验,针对没有其他良好选择的患者进行经导管主动脉瓣置换术。 同时,我们正在开发一种用于这些腔静脉主动脉通路的专用闭合装置。 我们正在帮助其他美国医疗中心开发自己的介入 MRI 项目。 总体而言,我们已经成功开发了用于心血管治疗的实时 MRI 的新颖应用,并且我们将继续致力于这些令人兴奋的新发展的临床应用。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Robert J Lederman其他文献

Lithography based resonant marker design for MRI catheter visualization
  • DOI:
    10.1186/1532-429x-18-s1-p208
  • 发表时间:
    2016-01-27
  • 期刊:
  • 影响因子:
  • 作者:
    Engin Baysoy;Dursun K Yildirim;Cagla Ozsoy;Adrienne C Washburn;Anthony Z Faranesh;Senol Mutlu;Robert J Lederman;Ozgur Kocaturk
  • 通讯作者:
    Ozgur Kocaturk
Spiral imaging with off-resonance reconstruction for MRI-guided cardiovascular catheterizations using commercial off-the-shelf nitinol guidewires
  • DOI:
    10.1186/1532-429x-18-s1-p216
  • 发表时间:
    2016-01-27
  • 期刊:
  • 影响因子:
  • 作者:
    Adrienne E Campbell-Washburn;Toby Rogers;Kanishka Ratnayaka;Burcu Basar;Ozgur Kocaturk;Hui Xue;Robert J Lederman;Michael S Hansen;Anthony Z Faranesh
  • 通讯作者:
    Anthony Z Faranesh
MRI compatible hemodynamic recording system
  • DOI:
    10.1186/1532-429x-15-s1-p22
  • 发表时间:
    2013-01-30
  • 期刊:
  • 影响因子:
  • 作者:
    Bo Xiao;John W Kakareka;Randall H Pursley;Thomas Pohida;Robert J Lederman;Anthony Faranesh
  • 通讯作者:
    Anthony Faranesh
Positive contrast spiral imaging of a nitinol guidewire
  • DOI:
    10.1186/1532-429x-17-s1-q15
  • 发表时间:
    2015-02-03
  • 期刊:
  • 影响因子:
  • 作者:
    Adrienne E Campbell-Washburn;Toby Rogers;Burcu Basar;Merdim Sonmez;Ozgur Kocaturk;Robert J Lederman;Michael Hansen;Anthony Z Faranesh
  • 通讯作者:
    Anthony Z Faranesh
Technologist primer for MRI right heart catheterization: the NIH and CNMC experience
  • DOI:
    10.1186/1532-429x-16-s1-t1
  • 发表时间:
    2014-01-16
  • 期刊:
  • 影响因子:
  • 作者:
    Jonathan R Mazal;Kendall O'Brien;William Schenke;Annette Stine;Laurie Grant;Anthony Z Faranesh;Kanishka Ratnayaka;Robert J Lederman
  • 通讯作者:
    Robert J Lederman

Robert J Lederman的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Robert J Lederman', 18)}}的其他基金

Diagnostic and interventional cardiovascular catheterization
诊断和介入心血管导管插入术
  • 批准号:
    8940179
  • 财政年份:
  • 资助金额:
    $ 144.51万
  • 项目类别:
Biological and mechanical therapies enabled by cardiovascular interventional MRI
心血管介入 MRI 实现生物和机械治疗
  • 批准号:
    7594421
  • 财政年份:
  • 资助金额:
    $ 144.51万
  • 项目类别:
MRI and X-ray catheter design and prototyping
MRI 和 X 射线导管设计和原型制作
  • 批准号:
    10929117
  • 财政年份:
  • 资助金额:
    $ 144.51万
  • 项目类别:
Diagnostic and interventional cardiovascular catheterization
诊断和介入心血管导管插入术
  • 批准号:
    9353171
  • 财政年份:
  • 资助金额:
    $ 144.51万
  • 项目类别:
Biological and mechanical therapies enabled by cardiovas
心血管支持的生物和机械疗法
  • 批准号:
    7321629
  • 财政年份:
  • 资助金额:
    $ 144.51万
  • 项目类别:
Biological and mechanical therapies enabled by cardiovas
心血管支持的生物和机械疗法
  • 批准号:
    6822883
  • 财政年份:
  • 资助金额:
    $ 144.51万
  • 项目类别:
Real-time MRI guided cardiovascular intervention
实时 MRI 引导心血管干预
  • 批准号:
    8557942
  • 财政年份:
  • 资助金额:
    $ 144.51万
  • 项目类别:
MRI catheter design and fabrication
MRI 导管设计和制造
  • 批准号:
    8344989
  • 财政年份:
  • 资助金额:
    $ 144.51万
  • 项目类别:
Real-time cardiovascular MRI and co-registration technical development
实时心血管MRI及联合配准技术开发
  • 批准号:
    8557994
  • 财政年份:
  • 资助金额:
    $ 144.51万
  • 项目类别:
MRI catheter design and fabrication
MRI 导管设计和制造
  • 批准号:
    8746879
  • 财政年份:
  • 资助金额:
    $ 144.51万
  • 项目类别:

相似海外基金

Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
  • 批准号:
    MR/Z503605/1
  • 财政年份:
    2024
  • 资助金额:
    $ 144.51万
  • 项目类别:
    Research Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
  • 批准号:
    2336167
  • 财政年份:
    2024
  • 资助金额:
    $ 144.51万
  • 项目类别:
    Standard Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
  • 批准号:
    2402691
  • 财政年份:
    2024
  • 资助金额:
    $ 144.51万
  • 项目类别:
    Standard Grant
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
  • 批准号:
    2341428
  • 财政年份:
    2024
  • 资助金额:
    $ 144.51万
  • 项目类别:
    Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
  • 批准号:
    24K12150
  • 财政年份:
    2024
  • 资助金额:
    $ 144.51万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
  • 批准号:
    DE240100561
  • 财政年份:
    2024
  • 资助金额:
    $ 144.51万
  • 项目类别:
    Discovery Early Career Researcher Award
RUI: Evaluation of Neurotrophic-Like properties of Spaetzle-Toll Signaling in the Developing and Adult Cricket CNS
RUI:评估发育中和成年蟋蟀中枢神经系统中 Spaetzle-Toll 信号传导的神经营养样特性
  • 批准号:
    2230829
  • 财政年份:
    2023
  • 资助金额:
    $ 144.51万
  • 项目类别:
    Standard Grant
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
  • 批准号:
    23K09542
  • 财政年份:
    2023
  • 资助金额:
    $ 144.51万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
  • 批准号:
    23K07552
  • 财政年份:
    2023
  • 资助金额:
    $ 144.51万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
  • 批准号:
    23K07559
  • 财政年份:
    2023
  • 资助金额:
    $ 144.51万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了