Real-time MRI guided cardiovascular intervention

实时 MRI 引导心血管干预

基本信息

项目摘要

During the past year we have continued our work applying rapid MRI to guide simple and complex mechanical and biological interventions. We have introduced MRI catheterization into standard clinical practice at the NIH clinical center, based on our earlier careful pilot research comparison of conventional X-ray and wholly MRI guided transfemoral pulmonary artery catheterization in adults. We continue to enhance the capabilities of MRI catheterization to characterize heart function in patients. We continue to test MRI pericardiocentesis procedure in humans. We are developing new approaches to connect different heart chambers without surgery in patients with congenital heart disease. We also continue work towards direct repair of congenital heart defects on small children who otherwise might require open surgical access. We have completed a strategic project to accomplish non-surgical extra-anatomic bypass (a bidirectional Glenn superior cavo-pulmonary shunt) in animals, and expect to be able to translate this into the care of children in upcoming years. We are developing other novel catheterization tools, for example, to access the aorta without surgery in patients with small leg arteries (especially women) and patients with severe peripheral artery disease. This key advance has been translated into over 40 patients in its first year of clinical adoption at multiple sites across the United States, where it has proven lifesaving in many cases. We have now begun to sponsor a multi-center trial of this transcaval approach to transcatheter aortic valve replacement in patients without other good options. Simultaneously we are developing a purpose-built closure device for these caval-aortic access ports. We are helping other US medical centers develop their own interventional MRI programs. Overall we have successfully developed novel applications of real-time MRI for cardiovascular treatments, and we continue to work to clinical applications of these exciting new developments.
在过去的一年中,我们继续应用快速MRI指导简单和复杂的机械和生物干预。 我们已经在NIH临床中心将MRI导管插入术引入标准临床实践,这是基于我们早期对成人常规X线和完全MRI引导的经股肺动脉导管插入术进行的仔细的初步研究比较。 我们将继续加强MRI导管插入术的能力,以表征患者的心脏功能。 我们继续在人体中测试MRI心包穿刺术。 我们正在开发新的方法来连接不同的心脏腔室,而无需手术治疗先天性心脏病患者。我们还继续致力于直接修复幼儿的先天性心脏缺陷,否则他们可能需要开放手术。 我们已经完成了一个战略项目,在动物身上实现非手术解剖外分流(双向Glenn上级腔肺分流),并期望在未来几年能够将其转化为儿童护理。 我们正在开发其他新的导管插入工具,例如,在小腿动脉患者(特别是女性)和严重外周动脉疾病患者中,无需手术即可进入主动脉。 这一关键进展已在美国多个地点的临床采用的第一年中转化为40多名患者,在许多情况下,它已被证明可以挽救生命。 我们现在已经开始赞助一项多中心试验,在没有其他良好选择的患者中采用这种经腔静脉方法进行经导管主动脉瓣置换术。 同时,我们正在为这些腔静脉-主动脉入口开发专用闭合装置。 我们正在帮助其他美国医疗中心开发自己的介入性MRI项目。 总的来说,我们已经成功地开发了实时MRI在心血管治疗中的新应用,我们将继续致力于这些令人兴奋的新发展的临床应用。

项目成果

期刊论文数量(0)
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Robert J Lederman其他文献

Lithography based resonant marker design for MRI catheter visualization
  • DOI:
    10.1186/1532-429x-18-s1-p208
  • 发表时间:
    2016-01-27
  • 期刊:
  • 影响因子:
  • 作者:
    Engin Baysoy;Dursun K Yildirim;Cagla Ozsoy;Adrienne C Washburn;Anthony Z Faranesh;Senol Mutlu;Robert J Lederman;Ozgur Kocaturk
  • 通讯作者:
    Ozgur Kocaturk
Spiral imaging with off-resonance reconstruction for MRI-guided cardiovascular catheterizations using commercial off-the-shelf nitinol guidewires
  • DOI:
    10.1186/1532-429x-18-s1-p216
  • 发表时间:
    2016-01-27
  • 期刊:
  • 影响因子:
  • 作者:
    Adrienne E Campbell-Washburn;Toby Rogers;Kanishka Ratnayaka;Burcu Basar;Ozgur Kocaturk;Hui Xue;Robert J Lederman;Michael S Hansen;Anthony Z Faranesh
  • 通讯作者:
    Anthony Z Faranesh
MRI compatible hemodynamic recording system
  • DOI:
    10.1186/1532-429x-15-s1-p22
  • 发表时间:
    2013-01-30
  • 期刊:
  • 影响因子:
  • 作者:
    Bo Xiao;John W Kakareka;Randall H Pursley;Thomas Pohida;Robert J Lederman;Anthony Faranesh
  • 通讯作者:
    Anthony Faranesh
Positive contrast spiral imaging of a nitinol guidewire
  • DOI:
    10.1186/1532-429x-17-s1-q15
  • 发表时间:
    2015-02-03
  • 期刊:
  • 影响因子:
  • 作者:
    Adrienne E Campbell-Washburn;Toby Rogers;Burcu Basar;Merdim Sonmez;Ozgur Kocaturk;Robert J Lederman;Michael Hansen;Anthony Z Faranesh
  • 通讯作者:
    Anthony Z Faranesh
Technologist primer for MRI right heart catheterization: the NIH and CNMC experience
  • DOI:
    10.1186/1532-429x-16-s1-t1
  • 发表时间:
    2014-01-16
  • 期刊:
  • 影响因子:
  • 作者:
    Jonathan R Mazal;Kendall O'Brien;William Schenke;Annette Stine;Laurie Grant;Anthony Z Faranesh;Kanishka Ratnayaka;Robert J Lederman
  • 通讯作者:
    Robert J Lederman

Robert J Lederman的其他文献

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{{ truncateString('Robert J Lederman', 18)}}的其他基金

Diagnostic and interventional cardiovascular catheterization
诊断和介入心血管导管插入术
  • 批准号:
    8940179
  • 财政年份:
  • 资助金额:
    $ 144.51万
  • 项目类别:
Biological and mechanical therapies enabled by cardiovascular interventional MRI
心血管介入 MRI 实现生物和机械治疗
  • 批准号:
    7594421
  • 财政年份:
  • 资助金额:
    $ 144.51万
  • 项目类别:
MRI and X-ray catheter design and prototyping
MRI 和 X 射线导管设计和原型制作
  • 批准号:
    10929117
  • 财政年份:
  • 资助金额:
    $ 144.51万
  • 项目类别:
Diagnostic and interventional cardiovascular catheterization
诊断和介入心血管导管插入术
  • 批准号:
    9353171
  • 财政年份:
  • 资助金额:
    $ 144.51万
  • 项目类别:
Biological and mechanical therapies enabled by cardiovas
心血管支持的生物和机械疗法
  • 批准号:
    6822883
  • 财政年份:
  • 资助金额:
    $ 144.51万
  • 项目类别:
Biological and mechanical therapies enabled by cardiovas
心血管支持的生物和机械疗法
  • 批准号:
    7321629
  • 财政年份:
  • 资助金额:
    $ 144.51万
  • 项目类别:
MRI catheter design and fabrication
MRI 导管设计和制造
  • 批准号:
    8746879
  • 财政年份:
  • 资助金额:
    $ 144.51万
  • 项目类别:
Real-time MRI guided cardiovascular intervention
实时 MRI 引导心血管干预
  • 批准号:
    8557942
  • 财政年份:
  • 资助金额:
    $ 144.51万
  • 项目类别:
MRI catheter design and fabrication
MRI 导管设计和制造
  • 批准号:
    8344989
  • 财政年份:
  • 资助金额:
    $ 144.51万
  • 项目类别:
Real-time cardiovascular MRI and co-registration technical development
实时心血管MRI及联合配准技术开发
  • 批准号:
    8557994
  • 财政年份:
  • 资助金额:
    $ 144.51万
  • 项目类别:

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