Precision Clinical Trial Recruitment to Promote Cancer Health Equity Across Florida

精准临床试验招募促进佛罗里达州癌症健康公平

• 批准号: 11002204
• 负责人: Olveen Carrasquillo
• 金额: $ 68.29万
• 依托单位: MAYO CLINIC JACKSONVILLE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-09 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/11002204
• 关键词: Precision; Clinical; Trial; Recruitment; Promote

PROJECT SUMMARY Racial and ethnic minorities represent the fastest growing segment of the United States adult population, yet they remain significantly underrepresented in cancer clinical trials (CCTs). Low trust in clinical research and recruitment approaches that fail to address multilevel barriers to CCT participation are key reasons for minority population underrepresentation. Community health educators (CHEs) improve trust in research among underrepresented populations, yet relying on exclusively on CHE availability can limit intervention reach. Virtual CHEs (vCHEs) improve scalability by extending CHE capabilities and capitalizing on remote recruitment techniques. The purpose of the current project is to increase referral of diverse participants to NCI-supported clinical trials via a culturally responsive, multi-level intervention that utilizes vCHEs to reach diverse populations. We will consolidate existing referral channels within the ALEX Research Portal. ALEX offers a custom experience for clinicians, CHEs, and patients to facilitate CCT referrals. Clinicians can utilize the portal to refer to CCTs; CHEs can use the portal to create an avatar that can provide introductory information to patients and schedule video-conference follow-ups; patients, families, and community members can use the portal to easily navigate to key information and make self- and other-referrals. The ability to streamline information to patients and CCT referrals to study coordinators is expected to improve the overall referral to CCTs. The ALEX Research Portal utilizes the adaptive virtual human technology developed at the University of Florida that provides users with culturally and linguistically tailored CCT information. The ALEX Research Portal will be developed and launched across three distinct geographic areas of Florida (Gainesville, Jacksonville, and Miami). This unique collaborative opportunity will provide access to participants representative of the racial and ethnic diversity of the state as well as cancer centers conducting CCTs associated with national networks (ETCTN, NCTN). Guided by the Interactive Systems Framework for dissemination and implementation, our goal is to increase referrals to CCTs by optimizing the ALEX Research Portal for broad use. The outcome will be an evidence-based intervention that can be widely disseminated to quickly increase the referral of diverse patients to CCTs. This project will be conducted in three phases: (Phase I) establish a baseline of referrals and accrual of diverse participants to CCTs across multiple Florida Center Centers, (Phase 2) adapt and pilot the ALEX Research Portal using a randomized controlled clinical trial, and (Phase 3) scale the intervention by dissemination via the OneFlorida network. The proposed study will result in an empirically-tested vCHE Research Portal for increasing trust in CCTs among diverse populations that can easily be adapted and disseminated across the state to overcome challenges associated with recruiting diverse participants to CCTs.

项目概要 少数种族和族裔是美国成年人口中增长最快的部分，但 他们在癌症临床试验（CCT）中的代表性仍然严重不足。对临床研究和信任度低 未能解决参与 CCT 的多层次障碍的招聘方法是少数群体的主要原因 人口代表性不足。社区健康教育者 (CHE) 提高人们对研究的信任 代表性不足的人群，但完全依赖 CHE 的可用性可能会限制干预范围。 虚拟 CHE (vCHE) 通过扩展 CHE 功能和利用远程招聘来提高可扩展性 技术。当前项目的目的是增加不同参与者向 NCI 支持的推荐 通过文化响应、多层次干预进行临床试验，利用 vCHE 来达到不同的目标 人口。我们将整合 ALEX 研究门户内现有的推荐渠道。亚历克斯提供了一个 为临床医生、CHE 和患者提供定制体验，以促进 CCT 转诊。临床医生可以利用该门户 参考 CCT； CHE 可以使用该门户创建一个头像，该头像可以提供介绍性信息 患者并安排视频会议随访；患者、家属和社区成员可以使用 门户可轻松导航至关键信息并进行自我推荐和他人推荐。精简能力 向患者提供信息以及向研究协调员转介 CCT 预计将改善整体转诊 相关色温。 ALEX 研究门户利用了大学开发的自适应虚拟人类技术 佛罗里达州为用户提供根据文化和语言量身定制的 CCT 信息。亚历克斯研究 门户网站将在佛罗里达州的三个不同地理区域（盖恩斯维尔、 杰克逊维尔和迈阿密）。这一独特的合作机会将为参与者提供机会 代表该州种族和民族多样性以及进行 CCT 的癌症中心 与国家网络（ETCTN、NCTN）相关。以交互系统框架为指导 传播和实施，我们的目标是通过优化 ALEX 研究来增加 CCT 的推荐 广泛使用的门户。结果将是一种基于证据的干预措施，可以广泛传播给 快速增加不同患者转诊至 CCT 的机会。该项目将分三个阶段进行：（阶段 I) 建立跨多个佛罗里达中心的 CCT 不同参与者的转介和累积基线 中心，（第 2 阶段）使用随机对照临床试验来调整和试点 ALEX 研究门户，以及 （第 3 阶段）通过 OneFlorida 网络传播来扩大干预范围。拟议的研究将导致 一个经过实证检验的 vCHE 研究门户，用于增强不同人群对 CCT 的信任， 易于在全州范围内进行调整和传播，以克服与招聘相关的挑战 CCT 的参与者多种多样。