Precision Clinical Trial Recruitment to Promote Cancer Health Equity Across Florida

精准临床试验招募促进佛罗里达州癌症健康公平

• 批准号: 11002204
• 负责人: Olveen Carrasquillo
• 金额: $ 68.29万
• 依托单位: MAYO CLINIC JACKSONVILLE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-09 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/11002204
• 关键词: Precision; Clinical; Trial; Recruitment; Promote

PROJECT SUMMARY Racial and ethnic minorities represent the fastest growing segment of the United States adult population, yet they remain significantly underrepresented in cancer clinical trials (CCTs). Low trust in clinical research and recruitment approaches that fail to address multilevel barriers to CCT participation are key reasons for minority population underrepresentation. Community health educators (CHEs) improve trust in research among underrepresented populations, yet relying on exclusively on CHE availability can limit intervention reach. Virtual CHEs (vCHEs) improve scalability by extending CHE capabilities and capitalizing on remote recruitment techniques. The purpose of the current project is to increase referral of diverse participants to NCI-supported clinical trials via a culturally responsive, multi-level intervention that utilizes vCHEs to reach diverse populations. We will consolidate existing referral channels within the ALEX Research Portal. ALEX offers a custom experience for clinicians, CHEs, and patients to facilitate CCT referrals. Clinicians can utilize the portal to refer to CCTs; CHEs can use the portal to create an avatar that can provide introductory information to patients and schedule video-conference follow-ups; patients, families, and community members can use the portal to easily navigate to key information and make self- and other-referrals. The ability to streamline information to patients and CCT referrals to study coordinators is expected to improve the overall referral to CCTs. The ALEX Research Portal utilizes the adaptive virtual human technology developed at the University of Florida that provides users with culturally and linguistically tailored CCT information. The ALEX Research Portal will be developed and launched across three distinct geographic areas of Florida (Gainesville, Jacksonville, and Miami). This unique collaborative opportunity will provide access to participants representative of the racial and ethnic diversity of the state as well as cancer centers conducting CCTs associated with national networks (ETCTN, NCTN). Guided by the Interactive Systems Framework for dissemination and implementation, our goal is to increase referrals to CCTs by optimizing the ALEX Research Portal for broad use. The outcome will be an evidence-based intervention that can be widely disseminated to quickly increase the referral of diverse patients to CCTs. This project will be conducted in three phases: (Phase I) establish a baseline of referrals and accrual of diverse participants to CCTs across multiple Florida Center Centers, (Phase 2) adapt and pilot the ALEX Research Portal using a randomized controlled clinical trial, and (Phase 3) scale the intervention by dissemination via the OneFlorida network. The proposed study will result in an empirically-tested vCHE Research Portal for increasing trust in CCTs among diverse populations that can easily be adapted and disseminated across the state to overcome challenges associated with recruiting diverse participants to CCTs.

项目摘要 种族和少数民族是美国成年人口中增长最快的部分， 他们在癌症临床试验（CCT）中的代表性仍然显著不足。对临床研究的信任度低， 招聘方法未能解决CCT参与的多层次障碍是少数人的主要原因。 人口代表性不足。社区卫生教育工作者（CHE）提高了对研究的信任， 虽然这类人群代表性不足，但完全依赖卫生保健服务的提供可能会限制干预措施的覆盖面。 虚拟CHE（vCHE）通过扩展CHE功能和利用远程招聘来提高可扩展性 技术.目前项目的目的是增加将不同参与者转介到国家癌症研究所支持的 临床试验，通过文化响应，多层次的干预，利用vCHE，以达到不同的 人口。我们将整合ALEX研究门户网站内的现有转介渠道。ALEX提供 为临床医生、CHE和患者提供定制体验，以促进CCT转诊。临床医生可以利用门户网站 以引用CCT; CHE可以使用门户创建可提供介绍性信息的头像， 患者和安排视频会议随访;患者，家属和社区成员可以使用 门户网站，以轻松地导航到关键信息，并使自我和他人转介。精简的能力 向患者提供信息和向研究协调员提供CCT转诊，预计将改善向 CCT。ALEX研究门户网站利用了自适应虚拟人技术， 佛罗里达，为用户提供文化和语言定制的CCT信息。ALEX研究 门户网站将在佛罗里达的三个不同的地理区域（盖恩斯维尔， 杰克逊维尔和迈阿密）。这一独特的合作机会将为参与者提供 代表国家的种族和民族多样性以及癌症中心进行CCT 与国家网络（ETCTN，NCTN）相关联。在交互式系统框架的指导下， 传播和实施，我们的目标是通过优化ALEX研究， 门户网站广泛使用。其成果将是一项循证干预措施，可广泛传播， 快速增加不同患者到CCT的转诊。该项目将分三个阶段进行： I）建立多个佛罗里达中心CCT的不同参与者的转诊和累积基线 中心，（2期）采用随机对照临床试验调整和试点ALEX研究门户网站，以及 （第三阶段）通过OneFlorida网络传播来扩大干预规模。拟议的研究将导致 一个经过验证的vCHE研究门户网站，用于增加不同人群对CCT的信任， 易于在全州范围内进行调整和传播，以克服与招聘相关的挑战 不同的CCT参与者。