Precision Clinical Trial Recruitment to Promote Cancer Health Equity Across Florida

精准临床试验招募促进佛罗里达州癌症健康公平

• 批准号: 11002204
• 负责人: Olveen Carrasquillo
• 金额: $ 68.29万
• 依托单位: MAYO CLINIC JACKSONVILLE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-09 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/11002204
• 关键词: Precision; Clinical; Trial; Recruitment; Promote

PROJECT SUMMARY Racial and ethnic minorities represent the fastest growing segment of the United States adult population, yet they remain significantly underrepresented in cancer clinical trials (CCTs). Low trust in clinical research and recruitment approaches that fail to address multilevel barriers to CCT participation are key reasons for minority population underrepresentation. Community health educators (CHEs) improve trust in research among underrepresented populations, yet relying on exclusively on CHE availability can limit intervention reach. Virtual CHEs (vCHEs) improve scalability by extending CHE capabilities and capitalizing on remote recruitment techniques. The purpose of the current project is to increase referral of diverse participants to NCI-supported clinical trials via a culturally responsive, multi-level intervention that utilizes vCHEs to reach diverse populations. We will consolidate existing referral channels within the ALEX Research Portal. ALEX offers a custom experience for clinicians, CHEs, and patients to facilitate CCT referrals. Clinicians can utilize the portal to refer to CCTs; CHEs can use the portal to create an avatar that can provide introductory information to patients and schedule video-conference follow-ups; patients, families, and community members can use the portal to easily navigate to key information and make self- and other-referrals. The ability to streamline information to patients and CCT referrals to study coordinators is expected to improve the overall referral to CCTs. The ALEX Research Portal utilizes the adaptive virtual human technology developed at the University of Florida that provides users with culturally and linguistically tailored CCT information. The ALEX Research Portal will be developed and launched across three distinct geographic areas of Florida (Gainesville, Jacksonville, and Miami). This unique collaborative opportunity will provide access to participants representative of the racial and ethnic diversity of the state as well as cancer centers conducting CCTs associated with national networks (ETCTN, NCTN). Guided by the Interactive Systems Framework for dissemination and implementation, our goal is to increase referrals to CCTs by optimizing the ALEX Research Portal for broad use. The outcome will be an evidence-based intervention that can be widely disseminated to quickly increase the referral of diverse patients to CCTs. This project will be conducted in three phases: (Phase I) establish a baseline of referrals and accrual of diverse participants to CCTs across multiple Florida Center Centers, (Phase 2) adapt and pilot the ALEX Research Portal using a randomized controlled clinical trial, and (Phase 3) scale the intervention by dissemination via the OneFlorida network. The proposed study will result in an empirically-tested vCHE Research Portal for increasing trust in CCTs among diverse populations that can easily be adapted and disseminated across the state to overcome challenges associated with recruiting diverse participants to CCTs.

项目总结 种族和少数民族是美国成年人口中增长最快的部分， 他们在癌症临床试验(CCT)中的代表性仍然很低。对临床研究的低信任度 未能解决参与有条件现金转移的多层次障碍的招聘方法是少数族裔的主要原因 人口代表性不足。社区健康教育者(CHS)提高人们对研究的信任 代表不足的人群，然而，完全依赖保健服务的可获得性可能会限制干预的覆盖范围。 虚拟CHE(VCHE)通过扩展CHE功能和利用远程招聘来提高可扩展性 技巧。当前项目的目的是将不同的参与者更多地转介到NCI支持的项目 通过文化响应、多层次干预的临床试验，利用vCHE覆盖不同的 人口。我们将整合Alex Research门户网站内现有的推荐渠道。亚历克斯提供了一个 为临床医生、CHS和患者提供定制体验，以促进CCT转诊。临床医生可以使用门户 引用CCT；CHE可以使用门户创建一个头像，该头像可以提供以下入门信息 患者和安排视频会议后续；患者、家属和社区成员可以使用 轻松导航到关键信息并进行自我推荐和他人推荐的门户。简化流程的能力 向患者提供信息，向研究协调员提供CCT转介，预计将改善转诊到 闭路电视。亚历克斯研究门户网站利用了加州大学开发的自适应虚拟人技术 佛罗里达州，为用户提供文化和语言上量身定做的CCT信息。亚历克斯研究公司 门户网站将在佛罗里达州的三个不同地理区域(盖恩斯维尔， 杰克逊维尔和迈阿密)。这一独特的协作机会将为参与者提供访问 该州种族和民族多样性的代表以及开展有条件现金转移治疗的癌症中心 与国家网络(ETCTN、NCTN)相关联。在交互系统框架的指导下 传播和实施，我们的目标是通过优化Alex Research来增加对CCT的转诊 门户网站，用途广泛。其结果将是一种基于证据的干预，可以广泛传播到 迅速增加不同患者转诊到有条件现金治疗中心的比例。该项目将分三个阶段进行：(阶段 I)建立多个佛罗里达中心不同参与者向CCT的转介和应计基准 中心，(第二阶段)使用随机对照临床试验调整和试点Alex Research门户网站，以及 (第三阶段)通过One佛罗里达网络传播来扩大干预规模。拟议的研究将导致 经过经验测试的vCHE研究门户，可提高不同人群对CCT的信任度， 轻松适应并在全州传播，以克服与招聘相关的挑战 参加有条件现金援助的人员多种多样。