Miami Clinical and Translational Science Institute

迈阿密临床与转化科学研究所

• 批准号: 10708431
• 负责人: Olveen Carrasquillo
• 金额: $ 399.1万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2030-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10708431
• 关键词: Acceleration; Address; Adoption; Advocate; Area; Behavior Therapy; Biomedical Research; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communities; Community Health; Complex; County; Cultural Diversity; Development; Devices; Disparity; Dissemination and Implementation; Education; Effectiveness; Ensure; Equity; Ethnic Origin; Federally Qualified Health Center; Florida; Future; Goals; Health; Health Benefit; Health Promotion; Healthcare Systems; Hispanic; Immigrant; Inequity; Interdisciplinary Study; International; Intervention; Knowledge acquisition; Language; Leadership; Medical; Mentors; Methods; Minority; Minority-Serving Institution; Participant; Patients; Persons; Pharmaceutical Preparations; Population; Positioning Attribute; Procedures; Process; Public Hospitals; Puerto Rico; Race; Reporting; Research; Research Personnel; Research Project Grants; Resources; Risk Factors; Safety; Science; Services; Shapes; Stigmatization; System; Testing; Training; Training Programs; Translational Research; Universities; Work; career development; clinical translation; community organizations; disorder risk; effective therapy; effectiveness evaluation; effectiveness research; equity, diversity, and inclusion; ethnic minority; experience; health disparity; health equity; health equity promotion; implementation efforts; improved; innovation; member; metropolitan; multidisciplinary; novel; programs; racial minority; recruit; research study; response; skills; socioeconomic disadvantage; successful intervention; tool; translational scientist

Project Summary Located in South Florida (SoFL), the goals of University of Miami’s Clinical and Translational Science Institute (CTSI) are to improve the health of our community, address health disparities, and promote health equity. The CTSI accomplishes these goals by catalyzing the development, demonstration, and dissemination of scientific and operational innovations that improve the efficiency, effectiveness, and quality of clinical and translational research. This is done through bidirectional engagement of diverse stakeholders, including patient advocates and community collaborators, to help identify gaps, challenges, and chokepoints in the translational research process. In response, the CTSI develops and test stakeholder-driven resources, tools, and interventions ultimately promoting the adoption and integration of those that are demonstrated to be successful, through dissemination and implementation efforts. This work is shaped by three primary factors: 1) SoFL is characterized by complex and multifaceted diversity with respect to race, ethnicity, language, immigrant status, socioeconomic disadvantage, and stigmatization. This complexity allows CTSI Hub investigators to explore research questions difficult to conceptualize and evaluate elsewhere; 2) CTSI prioritizes diversity, equity, inclusion, and accessibility (DEIA) in its scientific workforce and research participants; and 3) CTSI has a strong, successful and sustained record of authentic community and stakeholder engagement which facilitates multidisciplinary research that can successfully overcome the translational pitfall of replicating existing inequities. The CTSI’s focus, scope of activities and aims are grounded in an understanding of these factors and their complex interplay with one another. Together with diverse stakeholders, the CTSI will: 1) support the development and dissemination of innovative resources and services to increase the quality, efficiency, and effectiveness of research across the entire translational research spectrum; 2) promote research collaborations aimed at facilitating and accelerating research to improve community health, address health disparities, and promote health equity; 3) develop innovative training programs to support a team science-oriented CTS workforce, from translational scientists to clinical research professionals and key stakeholders; and 4) support CTS research responsive to these overarching goals. Through these efforts, the CTSI expects to achieve significant improvements in the quality, safety, efficiency, effectiveness, and informativeness of its Clinical and Translational Enterprise. The CTSI will then broadly disseminate its acquired knowledge regionally and nationally to maximize impact and opportunity, both now and in the future. By doing so, the CTSI accelerates bringing the benefits of translational science (more effective treatments, drugs, devices, behavioral interventions, and medical procedures) to all people, regardless of their identity or access. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

项目概要 迈阿密大学临床和转化科学研究所的目标位于南佛罗里达州 (SoFL) (CTSI) 的目标是改善我们社区的健康、解决健康差距并促进健康公平。这 CTSI 通过促进开发、演示和传播来实现这些目标 提高临床和治疗效率、有效性和质量的科学和运营创新 转化研究。这是通过不同利益相关者的双向参与来完成的，包括 患者权益倡导者和社区合作者，帮助确定治疗中的差距、挑战和瓶颈 转化研究过程。作为回应，CTSI 开发并测试利益相关者驱动的资源、工具、 和干预措施，最终促进那些被证明是有效的措施的采用和整合 通过传播和实施努力取得了成功。这项工作由三个主要因素决定： 1) SoFL 的特点是在种族、民族、语言、 移民身份、社会经济劣势和污名化。这种复杂性使得 CTSI Hub 研究人员探索其他地方难以概念化和评估的研究问题； 2）CTSI 在其科学劳动力和研究中优先考虑多样性、公平性、包容性和可及性 (DEIA) 参与者； 3) CTSI 在真实社区和社区方面拥有强大、成功和持续的记录 利益相关者的参与促进了多学科研究，可以成功克服 复制现有不平等的转化陷阱。 CTSI 的重点、活动范围和目标是 建立在对这些因素及其相互之间复杂相互作用的理解的基础上。连同 CTSI 将：1）支持创新资源的开发和传播， 提高整个转化研究质量、效率和有效性的服务 研究范围； 2）促进旨在促进和加速研究的研究合作 改善社区健康，解决健康差距，促进健康公平； 3）开发创新 培训计划，支持以科学为导向的 CTS 团队，从转化科学家到临床人员 研究专业人员和主要利益相关者； 4) 支持响应这些总体要求的 CTS 研究 目标。通过这些努力，CTSI 期望在质量、安全、 其临床和转化企业的效率、有效性和信息性。随后 CTSI 将 在区域和国家范围内广泛传播其获得的知识，以最大限度地发挥影响和机会， 现在和将来。通过这样做，CTSI 加速带来转化科学的好处（更多 有效的治疗、药物、设备、行为干预和医疗程序）给所有人， 无论他们的身份或访问权限如何。 PHS 398/2590（修订版 06/09） 页面延续 格式页面