REGULATION OF HISTIDINE BIOSYNTHESIS IN YEAST

酵母中组氨酸生物合成的调控

• 批准号: 2022045
• 负责人: GERALD R FINK
• 金额: $ 40.4万
• 依托单位: WHITEHEAD INSTITUTE FOR BIOMEDICAL RES
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-07-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2022045
• 关键词: Candida; Saccharomyces cerevisiae; aminoacid biosynthesis; cell cycle; enzyme substrate complex; fungal genetics; gene expression; genetic mapping; genetic promoter element; genetic recombination; genetic regulation; genetic transcription; histidine; meiosis; molecular cloning; molecular genetics; mutagen testing; nucleic acid hybridization; nucleic acid sequence; posttranslational modifications; protein structure function; site directed mutagenesis

DESCRIPTION: This represents a far ranging proposal to explore molecular mechanisms of regulation in yeast by one of the founders of yeast molecular biology. The four tangentially related objectives are: 1) post- translational control of the S. cerevisiae GCN4 gene; 2) regulation of intracellular levels of amino acids, particularly histidine, in S. cerevisiae; 3) probing for existencing of a multicopy silencing system in S. cerevisiae; and 4) testing for evidence of a meiotic cycle in C. albicans.

描述：这代表了一个广泛的建议，探索分子 酵母的创始人之一在酵母中的调节机制 分子生物学 四个密切相关的目标是：1） S.酿酒酵母GCN 4基因; 2） 调节细胞内氨基酸水平，特别是 组氨酸，在S.酿酒酵母; 3）探测多拷贝的存在 S.酿酒酵母;和4）测试的证据， 减数分裂周期C.白色念珠菌。