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VAGINAL IMMUNITY ROLE OF ENDOGENOUS/EXOGENOUS AGENTS

内源性/外源性物质的阴道免疫作用

基本信息

批准号：
2403521
负责人：
WILLIAM H KUTTEH
金额：
$ 16.25万
依托单位：
UNIVERSITY OF TENNESSEE HEALTH SCI CTR
依托单位国家：
美国
项目类别：
财政年份：
1995
资助国家：
美国
起止时间：
1995-09-01 至 1999-08-31
项目状态：
已结题

项目摘要

The immune system of the female genital tract comprises the components of mucosal (local) and systemic immune compartments. The relative contributions from these two compartments of the immune system are influenced to a different degree by biological and endocrinological factors including the menstrual cycle, use of hormonal supplements, local contraceptives, and infection. Therefore, the long-term objectives of the proposed studies are to determine the impact of such factors on the origin and transport of antibodies in female genital tract secretions, and on the B and T lymphocytes associated with the genital tissues. To address these considerations, the following specific aims are proposed: 1) to evaluate the effect of the endogenous and exogenous hormonal status on the immune system of the genital tract by measuring the levels, isotypes, and molecular forms of mucosal antibodies in cervical mucus and vaginal secretions collected from women during their menstrual cycle, in pregnancy, and in the menopause; 2) to evaluate the effect of local estrogens, spermicides, and anti-fungal agents on genital tract immunity in women during their reproductive years before and after treatment with such agents; and 3) to evaluate the relative contributions of uterine cervical and vaginal B and T cells and their products to the immune system of the genital tract before and after specific mucosal immunization. The accumulated results will provide basic information concerning the immunology of the female reproductive tract. We will ascertain the specific effects of hormones and other exogenous agents on immunoglobulin, cytokine, and secretory component expression and production in the genital tract. Rational approaches for further studies on the enhancement of immunity in the genital tract should evolve. The effects of hormonal therapy, local spermicides, and other factors on the integrity, enhancement, or suppression of the immune system of the female genital tract will be addressed in these studies.

女性生殖道的免疫系统由下列成分组成粘膜(局部)和系统免疫隔间。相对的来自免疫系统这两个部分的贡献是不同程度地受到生物学和内分泌学的影响因素包括月经周期、激素补充剂的使用、局部避孕药和感染。因此，该计划的长期目标拟议的研究是为了确定这些因素对起源的影响和抗体在女性生殖道分泌物中的运输，以及在与生殖器组织相关的B和T淋巴细胞。要解决这些问题考虑因素，提出了以下具体目标：1)评价内源性和外源性激素状态对免疫功能的影响通过测量水平、同种异型和宫颈粘液和阴道黏膜抗体的分子形式从女性月经周期收集的分泌物，在妊娠及更年期；2)评价局部用药效果雌激素、杀精剂和抗真菌药物对生殖道免疫的影响在治疗前后的育龄妇女中，使用 3)评价子宫的相对贡献。宫颈和阴道B、T细胞及其产物对免疫系统的影响在特定的粘膜免疫前后生殖道的变化。这个累积结果将提供有关以下方面的基本信息女性生殖道免疫学。我们将确定激素和其他外源性因素对免疫球蛋白的特异性影响，细胞因子和分泌成分在生殖器中的表达和产生一条小路。加强生态文明建设进一步研究的理性途径生殖道中的免疫力应该会进化。荷尔蒙的影响治疗、局部杀精剂等因素对诚信的影响，增强或抑制女性生殖器的免疫系统在这些研究中将涉及到区域。