COG Biobanking Support

COG 生物样本库支持

• 批准号: 10912948
• 负责人: Mignon Lee-Cheun Loh
• 金额: $ 290.09万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-22 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10912948
• 关键词: Address; Adolescent; Affect; Basic Science; Biological; Biological Specimen Banks; Child; Childhood; Childhood Cancer Treatment; Clinical; Clinical Research; Clinical Trials; Clinical Trials Cooperative Group; Collection; Communities; Cooperative Human Tissue Network; Data; Data Coordinating Center; Databases; Diagnosis; Enrollment; Ensure; Ethnic Origin; Geography; Guidelines; Human; Immunologic Monitoring; Institution; Malignant - descriptor; Malignant Childhood Neoplasm; Malignant Neoplasms; National Clinical Trials Network; Outcome; Pediatric Hospitals; Pediatric Oncology Group; Procedures; Quality Control; Race; Randomized; Research; Research Institute; Research Personnel; Residual state; Resources; Translational Research; Tumor Bank; United States; anticancer research; biobank; clinical trial protocol; improved; informatics tool; participant enrollment; population based; satisfaction; technological innovation

Project Summary The Children’s Oncology Group (COG) is the pediatric clinical trials group of the National Clinical Trials Network (NCTN). Over 90% of United States and Canadian children and adolescents with cancer are treated at COG institutions with no racial, ethnic or geographic bias to registration, allowing for near- population-based clinical, translational and basic research. COG has established a strong track record of collecting and banking tumor and non-diseased biospecimens from patients enrolled in COG-sponsored clinical trials, most of which include randomized treatment questions. The COG Biospecimen Bank (COG Biobank), located within the Biopathology Center (part of the Abigail Wexner Research Institute at Nationwide Children’s Hospital), aims to provide high-quality pediatric and adolescent human malignant biospecimens to the research community. Upon review and approval, biospecimens are prioritized for distribution to the COG investigators defined in the clinical trial protocols. After the needs of the planned research have been addressed, residual (legacy) banked biospecimens can be distributed to other investigators within and outside COG via the NCTN Navigator The COG Group and Biobank Concierges can also facilitate access to COG legacy biospecimens that are not currently uploaded in Navigator. For all biospecimen distribution projects, a feasibility assessment by the COG Biobank and the COG Statistical and Data Management Center (SDMC) is completed prior to proposal submission. This proposal supports the collection, processing, and distribution of biospecimens from patient enrolled on COG-sponsored trials. The Pediatric Division of the Cooperative Human Tissue Network (CHTN) then facilitates the distribution of the approved legacy biospecimens. The COG Biobank seeks to directly promote and support outstanding research in the diagnosis and treatment of pediatric cancer through centralized collection, quality control, storage, and distribution procedures. The COG Biobank will continue efforts to provide the latest biorepository-based technological innovations and best practices, resulting in constant improvements in our operational capabilities, investigator access to biospecimens, investigator satisfaction, and the stewardship of these precious resources. Under proper regulatory guidelines and in association with the COG SDMC, the COG Biobank will support translational aspects of cutting-edge research by ensuring appropriate tracking of biospecimens as well as linkage to existing demographic, clinical, biological, treatment, and outcome data. Finally, the COG Biobank will provide investigators with a comprehensive database solution and dynamic informatics tools that facilitate pediatric cancer research. The COG Biobank also plans to support the processing, banking, and distribution of biospecimens to the Cancer Immune Monitoring and Analysis Centers (CIMACs).

项目总结

项目成果

A Novel EGFR Extracellular Domain Mutant, EGFRΔ768, Possesses Distinct Biological and Biochemical Properties in Neuroblastoma.

• DOI: 10.1158/1541-7786.mcr-15-0477
• 发表时间: 2016-08
• 期刊: Molecular cancer research : MCR
• 作者: Keller J;Nimnual AS;Varghese MS;VanHeyst KA;Hayman MJ;Chan EL
• 通讯作者: Chan EL

Clinically and biologically relevant subgroups of Wilms tumour defined by genomic and epigenomic analyses.

• DOI: 10.1038/s41416-020-01102-1
• 发表时间: 2021-01
• 期刊: British journal of cancer
• 影响因子: 8.8
• 作者: Brzezinski J;Choufani S;Romao R;Shuman C;Chen H;Cunanan J;Bagli D;Grant R;Lorenzo A;Weksberg R
• 通讯作者: Weksberg R

XPO1 inhibition with selinexor synergizes with proteasome inhibition in neuroblastoma by targeting nuclear export of IkB.

• DOI: 10.1016/j.tranon.2021.101114
• 发表时间: 2021-08
• 期刊: Translational oncology
• 影响因子: 5
• 作者: Galinski B;Luxemburg M;Landesman Y;Pawel B;Johnson KJ;Master SR;Freeman KW;Loeb DM;Hébert JM;Weiser DA
• 通讯作者: Weiser DA

ATP Binding Cassette C1 (ABCC1/MRP1)-mediated drug efflux contributes to disease progression in T-lineage acute lymphoblastic leukemia.

• DOI: 10.4236/health.2013.55a005
• 发表时间: 2013-05-01
• 期刊: Health
• 影响因子: 2.1
• 作者: Winter, Stuart S;Ricci, Jerec;Larson, Richard S
• 通讯作者: Larson, Richard S

Molecular characterization and clinical outcome of B-cell precursor acute lymphoblastic leukemia with IG-MYC rearrangement.

• DOI: 10.3324/haematol.2021.280557
• 发表时间: 2023-03-01
• 期刊: HAEMATOLOGICA
• 影响因子: 10.1
• 作者: Bomken, Simon;Enshaei, Amir;Schwalbe, Edward C.;Mikulasova, Aneta;Dai, Yunfeng;Zaka, Masood;Fung, Kent T. M.;Bashton, Matthew;Lim, Huezin;Jones, Lisa;Karataraki, Nefeli;Winterman, Emily;Ashby, Cody;Attarbaschi, Andishe;Bertrand, Yves;Bradtke, Jutta;Buldini, Barbara;Burke, G. A. Amos;Cazzaniga, Giovanni;Goehring, Gudrun;de Groot-Kruseman, Hesta A.;Haferlach, Claudia;Lo Nigro, Luca;Parihar, Mayur;Plesa, Adriana;Seaford, Emma;Sonneveld, Edwin;Strehl, Sabine;van der Velden, Vincent H. J.;Rand, Vikki;Hunger, Stephen P.;Harrison, Christine J.;Bacon, Chris M.;van Delft, Frederik W.;Loh, Mignon L.;Moppett, John;Vormoor, Josef;Walker, Brian A.;Moorman, Anthony V.;Russell, Lisa J.
• 通讯作者: Russell, Lisa J.