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Generating new mouse models

Generating new mouse models
生成新的鼠标模型
批准号：
10908197
负责人：
Karl Eric Pfeifer
金额：
$91.98万
依托单位：
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10908197
关键词：
Chemotherapy-Oncologic ProcedureES Cell LineElectroporationEmbryoEnhancersEpigenetic ProcessFertilityGene Expression RegulationGenome StabilityGoalsHematopoiesisImmune systemImplantInjectionsIntramural Research ProgramModelingMusMutant Strains MiceMutateNational Institute of Child Health and Human DevelopmentOperative Surgical ProceduresPathway interactionsProceduresProtocols documentationRNA metabolismResearchResearch PersonnelResearch SupportScientistSignal PathwayT-Cell DevelopmentThymus GlandUnited States National Institutes of HealthWorkanti-cancerblastocystdesignembryonic stem cellimmune functionmouse modelnovelstem cell biologyzygote

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中文摘要
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英文摘要
During the last year our research core has worked with seven NIH research units to generate novel embryonic stem cell lines and new mouse models. This research included establishment of models to study signal pathway interactions in the immune system, T cell development, hematopoiesis, stem cell biology, epigenetic inheritance in the early embryo, mechanisms regulating genomic stability, RNA metabolism, and gene regulation and enhancer function. We also performed specialized surgeries including thymus implants to support research on immune function. Finally we established mouse models to evaluate the effects of anti-cancer chemotherapies given to prepubescent mice on their long term fertility.
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Epigenetic mechanisms regulating the Igf2/H19 and Kcnq1 locus
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