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Generating new mouse models

Generating new mouse models
生成新的鼠标模型
批准号：
10908197
负责人：
Karl Eric Pfeifer
金额：
$91.98万
依托单位：
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10908197
关键词：
Chemotherapy-Oncologic ProcedureES Cell LineElectroporationEmbryoEnhancersEpigenetic ProcessFertilityGene Expression RegulationGenome StabilityGoalsHematopoiesisImmune systemImplantInjectionsIntramural Research ProgramModelingMusMutant Strains MiceMutateNational Institute of Child Health and Human DevelopmentOperative Surgical ProceduresPathway interactionsProceduresProtocols documentationRNA metabolismResearchResearch PersonnelResearch SupportScientistSignal PathwayT-Cell DevelopmentThymus GlandUnited States National Institutes of HealthWorkanti-cancerblastocystdesignembryonic stem cellimmune functionmouse modelnovelstem cell biologyzygote

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中文摘要
翻译
在过去的一年里，我们的研究核心与美国国立卫生研究院的七个研究单位合作，创造了新的胚胎干细胞系和新的小鼠模型。这项研究包括建立模型以研究免疫系统、T细胞发育、造血、干细胞生物学、早期胚胎的表观遗传、调节基因组稳定性的机制、RNA代谢以及基因调节和增强子功能的信号通路相互作用。我们还进行了包括胸腺植入在内的专门手术，以支持免疫功能的研究。最后，我们建立了小鼠模型来评估给予青春期前小鼠的抗癌化疗对它们长期生育能力的影响。
英文摘要
During the last year our research core has worked with seven NIH research units to generate novel embryonic stem cell lines and new mouse models. This research included establishment of models to study signal pathway interactions in the immune system, T cell development, hematopoiesis, stem cell biology, epigenetic inheritance in the early embryo, mechanisms regulating genomic stability, RNA metabolism, and gene regulation and enhancer function. We also performed specialized surgeries including thymus implants to support research on immune function. Finally we established mouse models to evaluate the effects of anti-cancer chemotherapies given to prepubescent mice on their long term fertility.
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Epigenetic mechanisms regulating the Igf2/H19 and Kcnq1 locus
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