SBIR TOPIC 401 PHASE II:

SBIR 主题 401 第二阶段：

• 批准号: 10923637
• 负责人: PEYMON GHAZI, PH.D.
• 金额: $ 199.81万
• 依托单位: MALCOVA INC
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-18 至 2025-09-17
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10923637
• 关键词: 3-Dimensional; Anatomy; Brain; Brain imaging; Breast; Clinical Trials; Development; Diagnostic; Ensure; Health; Investigation; Life; Methods; Organ; Patient Recruitments; Patients; Performance; Phase; Prostate; Radiation therapy; Risk Reduction; Safety; Shapes; Small Business Innovation Research Grant; Speed; Technology; X-Ray Computed Tomography; breast imaging; cancer imaging; commercialization; design; fabrication; improved; large datasets; lung imaging; malignant breast neoplasm; novel strategies; validation studies

As long as breast cancer remains a pervasive health concern, the need for ever-improving breast cancer imaging and radiation therapy technologies will exist. Design changes – to incorporate new hardware technologies or methods - may trigger the need for clinical trials to ensure safety and assess performance. Conducting a clinical trial is not only expensive, but often takes years for patient recruitment and study. Utilizing physical phantoms, rather than patients, would be faster, far less expensive, reduces risk to patients and potentially increases the speed with which life-saving technological advances are made available to the public. Currently, commercially available compressed and uncompressed breast phantoms do not produce realistic breast images; rather they provide basic breast shapes with no anatomical information. Utilizing access to a large data set (over 200) of three-dimensional real patient breast CT images at UC Davis, and a novel approach to phantom development, we propose to fill this need. In this Phase II SBIR project, we will develop, and commercialize, patient-derived anthropomorphic phantoms for use in diagnostic and radiation therapy applications. We will also investigate the utility of our core technology in developing anthropomorphic phantoms for prostate, brain, and lung imaging applications.

只要乳腺癌仍然是一个普遍的健康问题，就需要不断改进乳腺癌成像和放射治疗技术。设计变更（纳入新的硬件技术或方法）可能会引发临床试验的需要，以确保安全性和评估性能。进行临床试验不仅费用昂贵，而且通常需要数年时间进行患者招募和研究。使用实体模型而不是病人会更快、更便宜、降低病人的风险，并有可能加快向公众提供拯救生命的技术进步的速度。目前，市售的压缩和未压缩乳房模型无法产生逼真的乳房图像；相反，它们提供基本的乳房形状，但没有解剖学信息。我们建议利用加州大学戴维斯分校的三维真实患者乳房 CT 图像的大型数据集（超过 200 个）以及一种新颖的体模开发方法来满足这一需求。在这个 II 期 SBIR 项目中，我们将开发并商业化源自患者的拟人模型，用于诊断和放射治疗应用。我们还将研究我们的核心技术在开发用于前列腺、大脑和肺部成像应用的拟人模型方面的效用。