Workshop on Statistical Genetic Methods for Human Complex Traits

项目总结 该提案要求再提供五年的资金，以支持组织和交付面对面和 虚拟强化培训研讨会的重点是发展统计、行为和 数量遗传学将推进NIMH的使命。四个研讨会将在一周内面对面进行 其中一个将在两周内成为虚拟的。我们还要求提供资金以支持一个网站的开发。 致力于这种材料的自我教育，这将极大地扩大研讨会的影响。这个 工作坊及其相关网站面向博士后实习生、研究生和医学生，以及 早期职业教师目前正在进行或计划启动心理健康遗传学的研究。至 使用各种方法平衡调查人员的需求，我们的面对面研讨会将交替进行 将重点放在双胞胎、家庭、多变量和发育数据的结构方程建模( “潜在遗传学课程”)，以及侧重于分析测量到的基因组变异的研讨会，包括 序列数据(“分子遗传学课程”)。虚拟课程将涵盖这两个内容领域， 稍微多一些介绍性的重点。该网站将成为学习所有内容的统计遗传学的中心枢纽 类型。它将由视频讲座、实践、代码和相关阅读材料以及一个论坛组成，所有这些 按主题和交叉引用进行组织。 通过授课和实践经验，参加研讨会的研究科学家将改进 他们在基因设计和分析方面的研究技能。研讨会提供了一个创新的计划，旨在 提供最先进的遗传方法学教育，对实现当前的目标很重要 NIMH战略计划。虽然是为培训而设计的，但现场(面对面和虚拟)研讨会分享了一些 科学会议的特点。鼓励参与者讨论他们目前的研究，带来 在研讨会期间直接处理他们的数据副本，并讨论和制定研究计划。新的 建立协作以促进对现有数据集的高质量研究，以及新的研究 讲习班上形成的协作加强了倡议。它的课程不断更新。 世界领先的统计、行为和数量遗传学及其在心理健康方面的应用。 从历史上看，这个研讨会是行为、统计和 数量遗传学。自1987年成立以来，它已经记录了约3,000次注册。很大比例的 论文的作者以“GWAS”和“孪生研究”为关键词参加了研讨会，许多 这一领域的领先者是从这方面开始的。建议的研讨会形式(面对面、虚拟和在线) 代表着内容交付方式的现代化，并已在扩大覆盖范围方面结出硕果 和多样性。

PROJECT SUMMARY This proposal requests a further five years of funding to support the organization and delivery of in-person and virtual intensive training workshops focused on the development of skills in statistical, behavioral, and quantitative genetics that will advance the mission of NIMH. Four workshops will be in-person over one week and one will be virtual across two weeks. We also request funding to support the development of a website devoted to self-education of this material and that will greatly increase the reach of the workshop. The workshop and its associated website are targeted at post-doctoral trainees, graduate and medical students, and early career faculty currently conducting or planning to initiate research on the genetics of mental health. To balance the needs of investigators using a variety of methodologies, our in-person workshops will alternate between a focus on structural equation modeling of twin, family, multivariate, and developmental data (the “Latent Genetics Course”), and a workshop focusing on the analysis of measured genome variation including sequence data (the “Molecular Genetics Course”). The virtual course will cover both content areas with a slightly more introductory focus. The website will be a central hub for learning statistical genetics of all content types. It will be made up of video lectures, practicals, code, and relevant readings along with a forum, all organized by topic and cross-referenced. Through both didactics and hands-on experience, research scientists participating in the workshops will refine their research skills in genetic design and analysis. The workshop offers an innovative program designed to provide education in state-of-the-art genetic methodology important to fulfill the objectives of the current NIMH Strategic Plan. Although designed for training, the live (in-person and virtual) workshops share some characteristics of a scientific meeting. Participants are encouraged to discuss their current research, to bring copies of their data to work on directly while at the workshop, and to discuss and develop research plans. New collaborations are established to facilitate high quality research on existing data sets, and new research initiatives are strengthened by collaborations formed at the workshop. Its curriculum is continuously updated by world leaders in statistical, behavioral, and quantitative genetics and their applications to mental health. This workshop has historically been one of the most important gateways to behavioral, statistical, and quantitative genetics. It has logged ~3,000 registrations since its inception in 1987. A large proportion of authors of papers with keywords such as “GWAS” and “twin studies” have attended the workshop and many leaders in the field got their start at it. The proposed workshop formats (in-person, virtual, and online) represent a modernization of how content is delivered and have already born fruit in terms of increased reach and diversity.