Workshop on Statistical Genetic Methods for Human Complex Traits

项目总结 这项提议要求再提供五年的资金，以支持组织和交付工作， 举办为期一周的强化培训讲习班，重点是发展统计方面的技能 将推进NIMH使命的遗传学。该研讨会面向博士后实习生、研究生 和医学生(医学博士和博士)，以及从事心理健康研究的早期职业教师 由公共卫生服务机构提供，他们目前正在进行或计划启动对人类基因组遗传学的研究 与心理健康有关的复杂特征。以便在调查人员的需求之间保持平衡 进行不同类型的研究和使用各种方法的研究，我们建议交替进行 在专注于双胞胎、家庭、多变量和发育的结构方程建模的研讨会之间 数据，以及侧重于包括序列数据在内的基因组变异分析的讲习班。自.以来 自1987年讲习班开始以来，已有2000多人报名参加这项培训。其中二十四个 31个研讨会由现任PI(John Hewitt)在科罗拉多州博尔德市主办。虽然这是一次培训 研讨会，它有一些科学会议的特点。鼓励参与者讨论他们的 目前的研究，带着他们的数据的副本在研讨会上直接工作，并讨论和 制定研究计划。建立新的合作关系，以促进高质量的研究和 关于现有数据集的出版和新的研究举措因专家的协作而得到加强 与方法论专家一起专注于表型研究。工作坊的课程不断更新 由世界领先的统计和计算遗传学及其在心理健康方面的应用。这项建议 遵循PA编号中的指南：PAR-17-082心理健康相关研究短期课程 教育和扩展以前由赠款T35MH19392、T35MH19918和 R25MH019918。通过教学和实践经验，参与研究的科学家们 讲习班将完善他们在遗传和基因组设计和分析方面的研究技能。研讨会提供了一个 旨在提供最先进的统计遗传方法教育的创新教育计划 重要的是实现当前NIMH战略计划的目标，包括其第一个战略目标： 定义复杂行为的机制，特别是通过确定 与精神疾病相关的基因组和非基因组因素。

PROJECT SUMMARY This proposal requests a further five years of funding to support the organization and delivery, on five occasions, of a one week intensive training workshop focused on the development of skills in statistical genetics that will advance the mission of NIMH. The workshop is targeted at post-doctoral trainees, graduate and medical students (MDs and PhDs), and early career faculty carrying out mental health research supported by the Public Health Service, who are currently conducting or planning to initiate research on the genetics of complex traits involved in mental health. So as to keep a balance between the needs of investigators conducting different kinds of studies and those using a variety of methodologies, we propose to alternate between a workshop focusing on structural equation modeling of twin, family, multivariate, and developmental data, and a workshop focusing on the analysis of genome variation including sequence data. Since the inception of the workshops in 1987, there have been over 2000 registrations for this training. Twenty four of the 31 workshops have been hosted by the current PI (John Hewitt) in Boulder, Colorado. Although a training workshop, it shares some characteristics of a scientific meeting. Participants are encouraged discuss their current research, to bring copies of their data to work on directly while at the workshop, and to discuss and develop research plans. New collaborations are established to facilitate both high quality research and publication on existing data sets, and new research initiatives are strengthened by the collaboration of experts with a phenotypic focus with experts in methodology. The curriculum of the workshop is continuously updated by world leaders in statistical and computational genetics and their application to mental health. This proposal follows the guidelines in PA Number: PAR-17-082 for Short Courses for Mental Health-Related Research Education and extends the training work previously funded by grants T35MH19392, T35MH19918, and R25MH019918. Through both didactics and hands-on experience, research scientists participating in the workshops will refine their research skills in genetic and genomic design and analysis. The workshop offers an innovative educational program designed to provide education in state-of-the-art statistical genetic methods important to fulfill the objectives of the current NIMH Strategic Plan, including its first Strategic Objective: to define the mechanisms of complex behaviors, in particular through the research priority of identifying the genomic and non-genomic factors associated with mental illnesses.