Workshop on Statistical Genetic Methods for Human Complex Traits

项目摘要 该提案要求再提供五年的资金，以支持组织和交付， 举办了为期一周的强化培训讲习班，重点是发展统计技能， 遗传学将推进NIMH的使命。该研讨会是针对博士后培训生，研究生 和医学生（医学博士和博士），以及开展心理健康研究的早期职业教师 目前正在进行或计划开展遗传学研究的公共卫生服务部门， 复杂的心理健康特征以便在调查人员的需要之间保持平衡 进行不同类型的研究和使用各种方法的研究，我们建议交替 在一个专注于双胞胎，家庭，多变量和发展的结构方程模型的研讨会之间， 数据，以及一个侧重于包括序列数据在内的基因组变异分析的讲习班。以来 自1987年开办讲习班以来，已有2 000多人报名参加这一培训。24个 现任PI（John休伊特）在科罗拉多博尔德举办了31次研讨会。虽然训练 研讨会，它分享了科学会议的一些特点。鼓励与会者讨论他们的 当前的研究，在研讨会上直接携带数据副本进行工作，并进行讨论和 制定研究计划。建立新的合作，以促进高质量的研究， 通过专家合作，加强现有数据集的出版物和新的研究举措 与方法学专家一起研究表型讲习班的课程不断更新 世界领先的统计和计算遗传学及其在心理健康方面的应用。这项建议 遵循PA编号：PAR-17-082心理健康相关研究短期课程中的指导方针 教育和扩展以前由赠款T35 MH 19392，T35 MH 19918资助的培训工作， R25MH019918。通过教学法和实践经验，参加 讲习班将提高他们在遗传和基因组设计和分析方面的研究技能。研讨会提供了一个 创新教育计划，旨在提供最先进的统计遗传学方法的教育 重要的是实现当前NIMH战略计划的目标，包括其第一个战略目标： 定义复杂行为的机制，特别是通过研究优先确定 与精神疾病相关的基因组和非基因组因素。

PROJECT SUMMARY This proposal requests a further five years of funding to support the organization and delivery, on five occasions, of a one week intensive training workshop focused on the development of skills in statistical genetics that will advance the mission of NIMH. The workshop is targeted at post-doctoral trainees, graduate and medical students (MDs and PhDs), and early career faculty carrying out mental health research supported by the Public Health Service, who are currently conducting or planning to initiate research on the genetics of complex traits involved in mental health. So as to keep a balance between the needs of investigators conducting different kinds of studies and those using a variety of methodologies, we propose to alternate between a workshop focusing on structural equation modeling of twin, family, multivariate, and developmental data, and a workshop focusing on the analysis of genome variation including sequence data. Since the inception of the workshops in 1987, there have been over 2000 registrations for this training. Twenty four of the 31 workshops have been hosted by the current PI (John Hewitt) in Boulder, Colorado. Although a training workshop, it shares some characteristics of a scientific meeting. Participants are encouraged discuss their current research, to bring copies of their data to work on directly while at the workshop, and to discuss and develop research plans. New collaborations are established to facilitate both high quality research and publication on existing data sets, and new research initiatives are strengthened by the collaboration of experts with a phenotypic focus with experts in methodology. The curriculum of the workshop is continuously updated by world leaders in statistical and computational genetics and their application to mental health. This proposal follows the guidelines in PA Number: PAR-17-082 for Short Courses for Mental Health-Related Research Education and extends the training work previously funded by grants T35MH19392, T35MH19918, and R25MH019918. Through both didactics and hands-on experience, research scientists participating in the workshops will refine their research skills in genetic and genomic design and analysis. The workshop offers an innovative educational program designed to provide education in state-of-the-art statistical genetic methods important to fulfill the objectives of the current NIMH Strategic Plan, including its first Strategic Objective: to define the mechanisms of complex behaviors, in particular through the research priority of identifying the genomic and non-genomic factors associated with mental illnesses.