Adverse childhood experiences and alcohol misuse in Latino adolescents: testing biopsychosocial and cultural mechanisms supplement

项目摘要 这个K补充物的目的是为了在即将到来的分娩关键生活事件后请求支持。 我在2022年2月被授予K08奖，并在2022年6月生下了我的第一个孩子。在这四个月中 几个月后，我聘请并培训了一名研究助理，开始收集数据，并迅速休了产假。 由于预算有限，我每周只能支付研究助理时间的10个小时，这是 专门专注于招聘和数据收集。K08的目标是1)识别风险和保护 ACES-酒精使用环节中的因素，2)评估HPA轴功能(头发皮质醇)在ACES中的作用- 酒精滥用与相关保护因素的联系，以及3)探索表观遗传机制(唾液DNA 甲基化)连接ACE和HPA轴的功能。尽管我孩子的健康问题和有限的 研究助理支持，我在我的K08项目上取得了重大进展，包括在 一年内150名目标参与者，完成哈佛大学的课程作业，参与当地和全国 发表演讲，出版15篇合著手稿。然而，尽管我的K08取得了很好的进步 目标，这是一个不可持续的速度，特别是考虑到我的孩子的医疗并发症。 因此，我申请K08增刊的目的是为我申请资金，以便聘请一名全职 研究助理和资助一名兼职生物统计师。研究助理和生物统计学家将协助我 我现在正在承担的职责，并将在下一个项目阶段帮助开展其他活动(例如， 数据管理、分析、发布初步数据)并支持我的目标，提交我的第一个R01 即将到来的一年。考虑到表观遗传学分析是如此昂贵，我不得不将我早年的大部分时间 用于表观遗传学分析的研究预算。然而，我在3.5-5年期间的预算几乎完全 分配给他们的时间，所以我应该能够在补充结束时恢复全部工作效率 句号。

Project Summary The purpose of this K supplement is to request support following the impending critical life event of childbirth. I was awarded the K08 award in February 2022 and gave birth to my first child in June 2022. During these four months, I hired and trained a research assistant, started data collection, and promptly went on maternity leave. Given budgetary constraints, I am only able to pay for 10 hours a week of a research assistant’s time, which is exclusively focused on recruitment and data collection. The K08 aims are to 1) identify risk and protective factors in the ACEs-alcohol use link, 2) evaluate the role of HPA axis functioning (hair cortisol) in the ACEs- alcohol misuse link and identify relevant protective factors and 3) explore epigenetic mechanisms (saliva DNA methylation) linking ACEs and HPA axis functioning. Despite my child’s health problems and the limited research assistant support, I have made significant progress on my K08 project, including enrolling 140 of the 150 target participants in a year, completing coursework at Harvard, engaging in local and national presentations, and publishing 15 co-authored manuscripts. However, despite the excellent progress on my K08 goals, it has been done at an unsustainable pace, particularly given my child’s medical complications. Therefore, the purpose of my K08 Supplement application is to request funding for me to hire a full-time research assistant and fund a part-time biostatistician. The research assistant and biostatistician will assist me with the duties I am assuming right now and will help with additional activities in the next project phases (e.g., data management, analysis, publishing preliminary data) and support me in my goal to submit my first R01 this upcoming year. Given that epigenetic analysis is so costly, I have had to allocate most of my earlier years of the research budget towards epigenetic analysis. However, my budget during years 3.5-5 are almost exclusively allocated to fund their time, so I should be able to return to full productivity at the end of the supplemental period.