Adverse childhood experiences and alcohol misuse in Latino adolescents: testing biopsychosocial and cultural mechanisms supplement

项目摘要 这种K补充的目的是在分娩这一即将发生的重大生命事件之后请求支持。 我于2022年2月获得K 08奖，并于2022年6月生下第一个孩子。这四 几个月后，我雇佣并培训了一名研究助理，开始收集数据，并立即休了产假。 考虑到预算限制，我只能支付每周10小时的研究助理时间，这是一个很大的负担。 专注于招聘和数据收集。K 08的目标是1）识别风险和保护 ACE-酒精使用联系中的因素，2）评估HPA轴功能（头发皮质醇）在ACE中的作用- 酒精滥用的联系，并确定相关的保护因素和3）探索表观遗传机制（唾液DNA 甲基化）连接ACE和HPA轴功能。尽管我的孩子的健康问题和有限的 在研究助理的支持下，我在K 08项目上取得了重大进展，包括招收了140名 一年150名目标参与者，在哈佛完成课程，参与地方和国家 出版了15本合著的手稿。然而，尽管我的K 08取得了很好的进展， 尽管我们没有实现目标，但它的速度是不可持续的，特别是考虑到我孩子的医疗并发症。 因此，我的K 08补充申请的目的是为我申请资金，以聘请全职 研究助理和基金兼职生物统计学家。研究助理和生物统计学家将协助我 我现在承担的职责，并将在下一个项目阶段帮助其他活动（例如， 数据管理、分析、发布初步数据），并支持我实现提交第一个R 01的目标， 即将到来的一年考虑到表观遗传分析是如此昂贵，我不得不把我早年的大部分时间分配给 用于表观遗传分析的研究预算。然而，我在3.5-5年的预算几乎完全是 分配给他们的时间，所以我应该能够在补充结束时恢复全部生产力 期

Project Summary The purpose of this K supplement is to request support following the impending critical life event of childbirth. I was awarded the K08 award in February 2022 and gave birth to my first child in June 2022. During these four months, I hired and trained a research assistant, started data collection, and promptly went on maternity leave. Given budgetary constraints, I am only able to pay for 10 hours a week of a research assistant’s time, which is exclusively focused on recruitment and data collection. The K08 aims are to 1) identify risk and protective factors in the ACEs-alcohol use link, 2) evaluate the role of HPA axis functioning (hair cortisol) in the ACEs- alcohol misuse link and identify relevant protective factors and 3) explore epigenetic mechanisms (saliva DNA methylation) linking ACEs and HPA axis functioning. Despite my child’s health problems and the limited research assistant support, I have made significant progress on my K08 project, including enrolling 140 of the 150 target participants in a year, completing coursework at Harvard, engaging in local and national presentations, and publishing 15 co-authored manuscripts. However, despite the excellent progress on my K08 goals, it has been done at an unsustainable pace, particularly given my child’s medical complications. Therefore, the purpose of my K08 Supplement application is to request funding for me to hire a full-time research assistant and fund a part-time biostatistician. The research assistant and biostatistician will assist me with the duties I am assuming right now and will help with additional activities in the next project phases (e.g., data management, analysis, publishing preliminary data) and support me in my goal to submit my first R01 this upcoming year. Given that epigenetic analysis is so costly, I have had to allocate most of my earlier years of the research budget towards epigenetic analysis. However, my budget during years 3.5-5 are almost exclusively allocated to fund their time, so I should be able to return to full productivity at the end of the supplemental period.