Adverse childhood experiences and alcohol misuse in Latino adolescents: testing biopsychosocial and cultural mechanisms.

拉丁裔青少年的不良童年经历和酒精滥用:测试生物心理社会和文化机制。

基本信息

  • 批准号:
    10574557
  • 负责人:
  • 金额:
    $ 16.12万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-02-20 至 2027-01-31
  • 项目状态:
    未结题

项目摘要

Project Summary Background. Latino adolescents have higher prevalence of alcohol consumption and binge drinking, start using drugs and alcohol earlier, and are at greater risk of developing addiction due to early use. It has been well documented that adverse childhood experiences (ACEs), such as abuse and neglect, significantly increase the risk for alcohol misuse. ACEs also affect HPA axis functioning and alter cortisol levels that can lead to mental health problems and alcohol use. More recently, epigenetic studies have uncovered that methylation of HPA axis genes affect cortisol levels and increase the risk for alcohol use disorder. More integrative research is needed to understand how biological and environmental factors interact to increase the vulnerability for alcohol misuse. Research Strategy. To obtain a more nuanced understanding of mechanisms leading to alcohol misuse, we hypothesize influences at the psychological (traumatic stressors), biological (genetics, endocrine), interpersonal (family cohesion), and cultural (values) level and identify paths of risk and resilience. The current project will assess the impact of ACEs on alcohol abuse and identify relevant protective factors (aim 1), evaluate the role of HPA axis functioning (hair cortisol) in the ACEs-alcohol misuse link and identify relevant protective factors (aim 2), and explore epigenetic mechanisms (saliva DNA methylation) linking ACEs and HPA axis functioning (hair cortisol; aim 3). The proposed study will leverage the structure and resources of the candidate primary mentor’s parent R01 and select a subsample of Latino adolescents (N= 150), for stress biomarkers collection (i.e., hair cortisol, saliva DNA methylation). Data yielded from the proposed study will lead to a future R01 examining the contribution of childhood adversities on biological vulnerabilities for alcohol use disorders longitudinally. Training Plan. In coordination with the research plan, the candidate will pursue training in the following three areas: (1) obtain training on alcohol epidemiology and etiology as a foundation to developing addiction prevention research with racial/ethnic minorities, (2) gain knowledge of epigenetics via DNA methylation, particularly in HPA axis and alcoholism-related genes, and (3) train in statistical genetics. Mentorship. Dr. Alegría is an expert in health and substance use disparities with extensive experience in mentoring early career investigators. Co-mentor Dr. Shields provides expertise on adversity-related epigenetics among minorities, co-mentor Dr. Zhang provides expertise in epigenetic influences in alcohol use disorders, and co-mentor Dr. Becker provides expertise in alcohol addiction among adolescents. A team of advisors provides additional expertise in biostatistics modeling of longitudinal data (Dr. Spiegelman) and in the impact of adversity on child endocrinology (Dr. Valentino). Candidate. The candidate is an early career scientist and clinical psychologist with extensive health disparities research experience. Together, the research and training experiences and expertise developed through this K08 award will support the applicant’s transition to research independence and ensure the applicant becomes a leading expert in biopsychosocial influences in minority addiction and health.
项目摘要 背景拉丁裔青少年饮酒和酗酒的患病率较高,开始使用 药物和酒精的早期使用,并在更大的风险发展成瘾,由于早期使用。已经充分 有证据表明,不良的童年经历(ACE),如虐待和忽视,显着增加 滥用酒精的风险。ACE还影响HPA轴功能,并改变皮质醇水平,从而导致精神 健康问题和酗酒。最近,表观遗传学研究发现HPA轴甲基化 基因影响皮质醇水平,增加酒精使用障碍的风险。需要更多的综合研究 了解生物和环境因素如何相互作用,增加滥用酒精的脆弱性。 研究战略。为了更细致地了解导致酒精滥用的机制,我们 假设心理(创伤性压力源),生物(遗传学,内分泌),人际关系 (家庭凝聚力)和文化(价值观)水平,并确定风险和复原力的途径。目前的项目将 评估ACE对酒精滥用的影响,并确定相关的保护因素(目标1),评估ACE的作用, HPA轴功能(头发皮质醇)在ACEs-酒精滥用联系,并确定相关的保护因素(目的 2),并探讨表观遗传机制(唾液DNA甲基化)连接ACE和HPA轴功能(头发 皮质醇; aim 3)。拟议的研究将利用候选人主要导师的结构和资源, 父母R 01,并选择拉丁裔青少年的子样本(N= 150),用于压力生物标志物收集(即,头发 皮质醇、唾液DNA甲基化)。从拟议的研究中获得的数据将导致未来的R 01检查 儿童期逆境对酒精使用障碍的生物脆弱性的纵向贡献。培训 计划根据研究计划,候选人将在以下三个方面进行培训:(1) 获得酒精流行病学和病因学培训,作为开展成瘾预防研究的基础 (2)通过DNA甲基化获得表观遗传学知识,特别是在HPA轴, 酒精中毒相关基因;(3)统计遗传学培训。导师制。阿莱格里亚博士是一位健康专家, 在指导早期职业调查人员方面具有丰富经验的人。共同导师Dr. Shields提供少数民族中与逆境相关的表观遗传学方面的专业知识,共同导师张博士提供 专业知识在酒精使用障碍的表观遗传影响,和共同导师博士贝克尔提供专业知识, 青少年的酒精成瘾。顾问团队提供生物统计学建模方面的额外专业知识 纵向数据(Spiegelman博士)和逆境对儿童内分泌学的影响(Valentino博士)。 候选人候选人是一个早期的职业科学家和临床心理学家与广泛的健康差距 研究经验。总之,通过K 08开发的研究和培训经验和专业知识 该奖项将支持申请人的过渡到研究的独立性,并确保申请人成为一个 在少数群体成瘾和健康的生物心理社会影响方面的领先专家。

项目成果

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Jenny Zhen-Duan其他文献

Jenny Zhen-Duan的其他文献

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{{ truncateString('Jenny Zhen-Duan', 18)}}的其他基金

Adverse childhood experiences and alcohol misuse in Latino adolescents: testing biopsychosocial and cultural mechanisms supplement
拉丁裔青少年的不良童年经历和酒精滥用:测试生物心理社会和文化机制补充
  • 批准号:
    10873557
  • 财政年份:
    2023
  • 资助金额:
    $ 16.12万
  • 项目类别:
Adverse childhood experiences and alcohol misuse in Latino adolescents: testing biopsychosocial and cultural mechanisms.
拉丁裔青少年的不良童年经历和酒精滥用:测试生物心理社会和文化机制。
  • 批准号:
    10368646
  • 财政年份:
    2022
  • 资助金额:
    $ 16.12万
  • 项目类别:

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