Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls.
Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls.
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DOI：
10.1016/j.envint.2022.107586
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发表时间：
2022-12
影响因子：
11.8
通讯作者：
Michels, Karin B.
中科院分区：
文献类型：
--
作者：
Yoon, Lara S.;Binder, Alexandra M.;Pereira, Ana;Calafat, Antonia M.;Shepherd, John;Corval, Camila;Michels, Karin B.
流行病学证据表明，环境因素作为内分泌干扰物（EDCs）与乳腺摄影乳腺密度和乳腺癌的风险有关。在青春期（乳房快速发育的时期）暴露于EDCs可能会影响乳腺癌发生的易感性。在来自生长和肥胖队列研究的366名智利青少年中，我们评估了青春期三个时间点15种可疑EDC生物标志物的尿液浓度之间的关系。（坦纳乳腺1期（B1）、4期（B4）和初潮后1年）和乳腺纤维腺体体积（FGV;百分比FGV [%FGV]和绝对FGV [aFGV]）和初潮后2年的总乳房体积（tBV）。我们使用线性混合模型来检验B4和初潮后1年与B1时肌酐校正的EDC生物标志物浓度的差异，并计算各时间点EDC浓度的组内相关系数（ICC），以评估测量结果的一致性。我们拟合多变量广义估计方程（GEE），以评估log 10转换的EDC和log 10转换的乳腺结局之间相关性的易感性窗口。GEE根据年龄、体脂百分比、总热量摄入和母亲教育进行调整。青春期不同时间点的尿液EDC生物标志物浓度差异很大（ICC范围为0.01-0.30）。对于12种内分泌干扰物，生物标志物浓度随时间推移而降低。初潮后1年测量的三氯生与初潮后2年的%FGV呈负相关（β = −0.025，95%置信区间= −0.041，−0.008）。B4时邻苯二甲酸单（2-乙基-5-羧基戊基）酯和邻苯二甲酸二（2-乙基己基）酯代谢物浓度总和与初潮后2年的aFGV和tBV呈正相关。没有测量的酚类与aFGV和tBV相关，而没有测量的对羟基苯甲酸酯与%FGV和aFGV相关。我们的研究表明，在青春期前后的EDC生物标志物浓度相对较高的变异性。我们还发现证据表明，可能有青春期窗口的敏感性，选择内分泌干扰物与青少年乳腺密度。
Epidemiologic evidence suggests that environmental factors acting as endocrine disrupting chemicals (EDCs) are associated with mammographic breast density and the risk of breast cancer. Exposure to EDCs during puberty, a period of rapid breast development, may affect susceptibility to breast carcinogenesis. In a cohort of 366 Chilean adolescents from the Growth and Obesity Cohort Study, we evaluated the relation between urinary concentrations of 15 suspected EDC biomarkers across three pubertal time points (Tanner breast stage 1 (B1), 4 (B4), and 1-year post-menarche) and breast fibroglandular volume (FGV; percent FGV [%FGV] and absolute FGV [aFGV]) and total breast volume (tBV) at 2-years post-menarche. We used linear mixed models to test differences in creatinine-corrected EDC biomarker concentrations at B4 and 1-year post-menarche compared to B1 and calculated intraclass correlation coefficients (ICC) of EDC concentrations across time points to appraise the consistency of measurements. We fit multivariable generalized estimating equations (GEEs) to evaluate windows of susceptibility for the association between log10-transformed EDCs and log10-transformed breast outcomes. GEEs were adjusted for age, body fat percentage, total caloric intake, and maternal education. Urinary EDC biomarker concentrations highly varied across pubertal time points (ICC range 0.01–0.30). For 12 EDCs, biomarker concentrations decreased over time. Triclosan measured at 1-year post-menarche was inversely associated with %FGV at 2-years post-menarche (β = −0.025, 95 % confidence interval = −0.041, −0.008). Mono(2-ethyl-5-carboxypentyl) phthalate and the sum of di(2-ethylhexyl) phthalate metabolite concentrations at B4 were positively associated with aFGV and tBV at 2-years post-menarche. No measured phenols were associated with aFGV and tBV, while no measured parabens were associated with %FGV and aFGV. Our study suggests relatively high variability in EDC biomarker concentrations across the peripubertal time period. We also found evidence to suggest that there may be pubertal windows of susceptibility to select EDCs for the association with adolescent breast density.
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影响因子：
11.8
作者：
Cantonwine, David E.;Cordero, Jose F.;Rivera-Gonzalez, Luis O.;Del Toro, Liza V. Anzalota;Ferguson, Kelly K.;Mukherjee, Bhramar;Calafat, Antonia M.;Crespo, Noe;Jimenez-Velez, Braulio;Padilla, Ingrid Y.;Alshawabkeh, Akram N.;Meeker, John D.
通讯作者：
Meeker, John D.
影响因子：
10.4
作者：
Birnbaum LS;Bucher JR;Collman GW;Zeldin DC;Johnson AF;Schug TT;Heindel JJ
通讯作者：
Heindel JJ
影响因子：
4.9
作者：
Cediel, G.;Corvalan, C.;Uauy, R.
通讯作者：
Uauy, R.
影响因子：
--
作者：
Frederiksen, H.;Sorensen, K.;Juul, A.
通讯作者：
Juul, A.
影响因子：
10.4
作者：
Calafat AM;Wong LY;Silva MJ;Samandar E;Preau JL Jr;Jia LT;Needham LL
通讯作者：
Needham LL