STRUCTURE AND DETERIORATION OF DECLARATIVE KNOWLEDGE

我们项目的这一部分探索了陈述性知识和 陈述性知识系统退化为 器质性脑部疾病。我们试图检验这样一个假设，即陈述性 记忆可以被看作是由适应性行为产生的， 分布式、交互式网络模型，而不是传统的 命题网络。我们将通过评估来检验这一假设 这类模型的模拟是否能够捕捉到 患者表现出的幸免和受损的表现 从进行性语义性痴呆综合征。该项目 将同时采用计算建模和实验 对语义性痴呆患者的调查。我们将a)开发一个 从暴露中学习概念的内部表示的模型 到具有代表性的命题陈述语料库；b)测试 模型~S有能力解释赤字的七个关键特征 由语义性痴呆患者表现出来，其中包括进行性 概念性知识退化、部分剩余知识 即使是受到严重影响的概念，也不涉及概念的各个方面 与其他相关概念共享，类别的可能影响 在备用知识、频率敏感性、 高频类别坐标作为图片命名中的错误，以及 内部和内部损失模式的高度一致性 任务之间；c)测试模型~S处理现象的能力 正常成年人表现出的，如原型性、基本的 水平和专业知识；收购顺序；以及对领域的敏感性 相关的底层关系信息，而不是表面信息 相似之处。然后我们将开发该模型的第二个版本，以 增加命题内容的灵活性，可以 表示，以便可以存储特定的事实和事件信息 以及一般的概念知识。我们将测试新的 模型对事实恶化模式的解释能力，以及 语义性痴呆患者的情景信息。这个 实验工作将产生用于培训 网络，并在测试中使用测试模型~S的充分性 解释了语义恶化的模式。的其他目标 实验工作是：a)检查内部的赤字模式 个别病人可口头报告的知识及 无需口头表述即可获取的知识。B)评估 具体情况(人、地点)的知识细目， 关于频率、一致性和类别一致性；以及 探索语义记忆和情景记忆之间的关系 语义记忆和言语产生之间的关系。这些测试将 评估企业间相互依存的整合程度 有问题的进程。

This part of our project explores the declarative knowledge and the deterioration of the declarative knowledge system as a function of organic brain disease. We seek to test the hypothesis that declarative memory can be seen as arising from the behavior of adaptive, distributed, interactive network models, rather than a conventional propositional network. We will test this hypothesis by assessing whether simulations of such models can capture the patterns of spared and impaired performance that are seen in patients suffering from the progressive syndrome of semantic dementia. The project will employ both computational modeling and experimental investigations with semantic dementia patients. We will a) develop a model that learns internal representations of concepts from exposure to a corpus of representative propositional statements; b) test the model~s ability to account for seven key characteristics of the deficits shown by semantic dementia patients, which include progressive deterioration of conceptual knowledge, partial residual knowledge even of severely affected concepts, sparing of aspects of concepts shared with other related concepts, possible effects of category coherence on spared knowledge, frequency sensitivity, occurrence of high-frequency category coordinates as errors in picture naming, and the high degree of consistency in the pattern of loss within and between tasks; c) Test the model~s ability to address phenomena exhibited by normal adults, such as effects of prototypicality, basic level, and expertise; order of acquisition; and sensitivity to domain relevant underlying relational information as opposed to surface similarity. We will then develop a second version of the model to increase the flexibility of the propositional content that can be represented, so that specific fact and event information can be stored along with general conceptual knowledge. We will test the new model's ability to account for pattern of deterioration of fact, and episodic information in semantic dementia patients. The experimental work will generate materials to be used in training the network, and to test use in testing the model~s adequacy in accounting for patterns of semantic deterioration. Additional aims of the experimental work are to a)Examine the pattern of deficits within individual patients with respect to verbally reportable knowledge and knowledge accessible without requiring verbalization. b)Assess the breakdown of knowledge of specific instances (people, places), with respect to frequency, consistency, and category coherence; and explore the relationships between semantic and episodic memory and between semantic memory and speech production. These tests will assess the degree of integration of interdependency among the processes in question.