SJOGREN'S SYNDROME SYMPOSIUM

要求提供资金以支持第二届国际 干燥综合征研讨会将在奥斯汀举行， 1988年10月23日至25日在德克萨斯州。这次会议是一个机会 对于国际当局以及许多美国人来说 风湿病学家讨论一种生物学上非常感兴趣的疾病， 牙科和医学。这次会议的具体需求 从这种多因素疾病的自然病史中走出来 吸引了基础医疗和医疗人员的极大兴趣 牙科科学家以及临床医生代表几个 不同的学科。该综合征被认为是 风湿性疾病，与类风湿性关节炎和 系统性红斑狼疮。研讨会的组织机构将 基础科学的进步(对疾病的基本了解 侧重于免疫遗传和自身免疫机制) 然后发展到医学和医学中的具体临床问题 牙科。自身抗原基因的克隆及其作用 淋巴因子和其他免疫调节因子，以及可能的 我们将讨论病毒感染的作用。我们的目标之一是 解决诊断分类的问题，因为许多患者 有重叠的临床症状，导致 近年来出现了相当大的困难，特别是在 到中枢神经系统的表现。 两个讲习班将讨论新的治疗形式和 干燥综合征的流行病学。所有美国国立卫生研究院的主管 将邀请受资助的多功能关节炎中心，希望 在这两个机构之间开展流行病学研究合作 中锋。本次会议将提供与以下内容相关的信息 生长因子和淋巴细胞生物学也可能刺激未来 干燥综合征后肿瘤及癌变的研究进展 是一种交界性疾病，5%-10%的患者会发展成 恶性淋巴组织增生症。

Funds are requested to support the Second International Symposium on Sjogren's Syndrome which will be held in Austin, Texas from October 23-25, 1988. This meeting is an opportunity for international authorities as well as many American rheumatologists to discuss a disease of great interest to biology, dentistry and medicine. The specific needs for this conference come out of the natural history of this multifactorial illness which has attracted considerable interest among basic medical and dental scientists as well as clinicians representing several different disciplines. The syndrome is considered one of the rheumatic diseases and is related to rheumatoid arthritis and systemic lupus erythematosus. The Symposium's organization will progress from basic science (understanding the disease at a basic level focusing on immunogenetic and autoimmune mechanisms) and then progress to specific clinical problems in medicine and dentistry. The cloning of autoantigen genes, the role of lymphokines and other immunoregulatory factors, and the possible role of virus infection will be discussed. One of our goals is to address the issue of diagnostic classification since many patients have overlapping clinical syndromes which have created considerable difficulties in recent years particularly with regard to central nervous system manifestations. Two workshops will deal with new forms of treatment and the epidemiology of Sjogren's Syndrome. The Directors of all NIH funded Multipurpose Arthritis Centers will be invited in hopes of developing an epidemiologic research collaboration between these centers. Information to come out of this meeting related to growth factors and lymphocyte biology may also stimulate future research in neoplasia and carcinogenesis since Sjogren's Syndrome is an interface disease in which 5-10% of patients develop malignant lymphoproliferation.