Genetic Basis of Variable Expression of Glycan Xeno-Autoantigens by Cattle

牛聚糖异种自身抗原变异表达的遗传基础

• 批准号: DP200103734
• 负责人: Prof Michael Jennings
• 金额: $ 33.72万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200103734
• 关键词: Genetic; Basis; Variable; Expression; Glycan

Meat and dairy products from cattle contain sugar structures (glycans) that are not made by humans. These structures can be recognised by the immune system and lead to allergic reactions, inflammation and potentially cancer. These non-human structures are called xeno-autoantigens or XAs. We have discovered individual cattle that do not produce one of these XAs. We will study the gene required to make XA in the XA-free cattle to find the underlying mutation. The same approach will be used to look for natural XA-free individuals in other food species. This knowledge may enable us to create a test to facilitate the natural breeding of non-GMO, XA-free livestock to benefit Australian primary producers and provide safer food for consumers.

来自牛的肉类和乳制品含有人类无法制造的糖结构（聚糖）。这些结构可以被免疫系统识别，并导致过敏反应，炎症和潜在的癌症。这些非人类结构被称为异种自身抗原或XA。我们发现个别牛不产生这些XA之一。我们将研究在不含XA的牛中制造XA所需的基因，以找到潜在的突变。同样的方法将用于寻找其他食物物种中的天然无XA个体。这一知识可能使我们能够创建一个测试，以促进非转基因，无XA牲畜的自然繁殖，使澳大利亚初级生产者受益，并为消费者提供更安全的食品。