Novel statistical genetic methods for DNA pooling

DNA 混合的新型统计遗传方法

• 批准号: nhmrc : 496675
• 负责人: A/Pr Stuart Macgregor
• 金额: $ 14.28万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-statistical-genetic-dna-pooling/101425
• 关键词: Novel; statistical; genetic; methods; DNA

Many recent gene mapping efforts have focused on population based approaches instead of previously used family based approaches. One of the limiting factors with population based approaches is the cost of the technology - each participant must be evaluated (or genotyped) for hundreds of thousands of genetic markers. The cost can be reduced by using an approach which pools individuals together for genotyping, with statistical models used to deal with the problems that this creates.

许多最近的基因定位工作都集中在人口为基础的方法，而不是以前使用的家庭为基础的方法。基于群体的方法的限制因素之一是技术的成本-每个参与者必须评估（或基因分型）数十万个遗传标记。通过将个体集中在一起进行基因分型，并使用统计模型来处理由此产生的问题，可以降低成本。