Linkage and association studies of schizophrenia in an isolated population.

孤立人群中精神分裂症的关联和关联研究。

• 批准号: nhmrc : 496698
• 负责人: A/Pr Stuart Macgregor
• 金额: $ 46.26万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/linkage-association-studies-isolated-population/82709
• 关键词: Linkage; association; studies; schizophrenia; isolated

The cause of schizophrenia is unknown, but there is good evidence that genes play a role. Geneticists do not fully understand how the disease is inherited, but it is very complex, and several interacting genes as well as environmental factors are likely involved. To address this complexity, we have recruited large schizophrenia pedigrees from the Iban of Sarawak, a geographically and genetically isolated population. This sample will help clarify the genetics of this devastating illness.

精神分裂症的原因尚不清楚，但有充分的证据表明基因起着作用。遗传学家并不完全了解这种疾病是如何遗传的，但它非常复杂，可能涉及几个相互作用的基因以及环境因素。为了解决这种复杂性，我们从砂拉越的依班人（Iban of Sarawak）中招募了大型精神分裂症家系，这是一个地理和遗传隔离的人群。这个样本将有助于澄清这种毁灭性疾病的遗传学。