OPTIMAL DESIGN OF THERMAL DEVICE FOR SKIN PERFUSION
皮肤灌注热装置的优化设计
基本信息
- 批准号:3431502
- 负责人:
- 金额:$ 3.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1988
- 资助国家:美国
- 起止时间:1988-02-15 至 1989-10-14
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
One of the most important measurements in biomedical research is
the determination of blood flow and tissue perfusion. Although a
few noninvasive methods have been studied extensively, these are
limited in application and accuracy. With the development of
sophisticated solid-state devices for heating and sensing
temperature, it is now possible to optimally design a measurement
system and experimental protocol to estimate flow in a given
tissue. Sensors can be fabricated in arrays of small individual
elements that can each produce a specified time-varying
temperature. For such a sensor to be optimally designed to
evaluate perfusion, it is necessary to develop a mathematical model
of heat transfer that incorporates sufficient detail of the
structure and properties of the tissue being measured and of the
device itself. The underlying hypothesis is that by producing a
temperature change at the tissue surface the subsequent dynamics
of the heat transfer rate measured at the same surface will depend
on the blood flow of the underlying tissue. Consequently, it
should be possible to interpret the sensor response to perfusion
at different depths and, thus, to estimate the blood flow in
different layers. To establish specifications of a multi-element,
multi-temperature heat flux sensor for estimating perfusion, we
shall use a mathematical model to simulate the dynamic responses
of the system. Furthermore, we can determine conditions under
which the responses are most sensitive and specific to blood flow.
With this information, we can develop simplified models to obtain
a practical method of signal processing. The initial goal is to
evaluate the dermal capillary-loop perfusion. The measurement of
skin perfusion and blood flow is important in understanding normal
skin physiology, thermal regulation, skin pathology and conditions
relating continuously monitored transcutaneous oxygen tension (a
widely applied instrument in critical care medicine) with central
arterial values. Although skin perfusion is important in its own
right, it is also essential for evaluating transcutaneous oxygen
tension by surface electrodes. Furthermore, if this basic approach
is feasible, then it can be applied to other medical applications
for the noninvasive evaluation of blood flow deeper in tissues.
生物医学研究中最重要的测量方法之一是
血流量和组织灌注的测定。 虽然
一些非侵入性方法已经被广泛研究,这些方法是
应用和准确性有限。 的发展
用于加热和传感的精密固态设备
温度,现在可以优化设计测量
用于估计给定流中流量的系统和实验协议
组织. 传感器可以被制造成小的个体阵列,
每个元素都可以产生一个指定的时变
温度 为了使这种传感器被最佳地设计成
评价灌注,有必要建立一个数学模型,
包含足够细节的传热
被测量的组织的结构和特性以及
装置本身。 潜在的假设是,通过产生一个
组织表面的温度变化
在同一表面测得的热传递率将取决于
对下层组织的血流有影响。 从而
应该可以解释传感器对灌注的反应
在不同的深度,因此,估计血液流量,
不同的层次。 为了建立多元件的规格,
用于估计灌注的多温度热通量传感器,
应使用数学模型来模拟动态响应
该系统 此外,我们可以确定条件下,
这些反应对血流最敏感和特异。
有了这些信息,我们可以开发简化的模型来获得
一种实用的信号处理方法。 最初的目标是
评价真皮毛细血管袢灌注情况。 的测量
皮肤灌注和血流对于理解正常
皮肤生理学、热调节、皮肤病理学和条件
将连续监测的经皮氧分压(a
在重症监护医学中广泛应用的仪器),
动脉值。 虽然皮肤灌注本身很重要,
对,它也是评估经皮氧的必要条件,
表面电极张力。 此外,如果这种基本方法
是可行的,那么它可以应用于其他医疗应用
用于无创评估组织中更深处的血流。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('GERALD M SAIDEL', 18)}}的其他基金
Center for Modeling Integrated Metabolic Systems (MIMS)
综合代谢系统建模中心 (MIMS)
- 批准号:
6773958 - 财政年份:2002
- 资助金额:
$ 3.75万 - 项目类别:
Center for Modeling Integrated Metabolic Systems (MIMS)
综合代谢系统建模中心 (MIMS)
- 批准号:
6543695 - 财政年份:2002
- 资助金额:
$ 3.75万 - 项目类别:
Thermal Model to Guide Tumor Ablation by RF Heating
通过射频加热指导肿瘤消融的热模型
- 批准号:
6469123 - 财政年份:2002
- 资助金额:
$ 3.75万 - 项目类别:
Thermal Model to Guide Tumor Ablation by RF Heating
通过射频加热指导肿瘤消融的热模型
- 批准号:
6670742 - 财政年份:2002
- 资助金额:
$ 3.75万 - 项目类别:
Thermal Model to Guide Tumor Ablation by RF Heating
通过射频加热指导肿瘤消融的热模型
- 批准号:
6936650 - 财政年份:2002
- 资助金额:
$ 3.75万 - 项目类别:
Center for Modeling Integrated Metabolic Systems (MIMS)
综合代谢系统建模中心 (MIMS)
- 批准号:
6919284 - 财政年份:2002
- 资助金额:
$ 3.75万 - 项目类别:
Center for Modeling Integrated Metabolic Systems (MIMS)
综合代谢系统建模中心 (MIMS)
- 批准号:
7090664 - 财政年份:2002
- 资助金额:
$ 3.75万 - 项目类别:
Center for Modeling Integrated Metabolic Systems (MIMS)
综合代谢系统建模中心 (MIMS)
- 批准号:
6640211 - 财政年份:2002
- 资助金额:
$ 3.75万 - 项目类别:
Thermal Model to Guide Tumor Ablation by RF Heating
通过射频加热指导肿瘤消融的热模型
- 批准号:
6787216 - 财政年份:2002
- 资助金额:
$ 3.75万 - 项目类别:
Center for Modeling Integrated Metabolic Systems (MIMS)
综合代谢系统建模中心 (MIMS)
- 批准号:
7252805 - 财政年份:2002
- 资助金额:
$ 3.75万 - 项目类别:
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