CCR Collaborative Bioinformatics Resource

CCR 协作生物信息学资源

• 批准号: 10926636
• 负责人: David Goldstein
• 金额: $ 258.41万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10926636
• 关键词: Area; Bioinformatics; Biological; CCR; Cells; Collaborations; Communities; Computer software; Data Analyses; Data Correlations; Databases; Ecosystem; Fostering; Genomics; Goals; Information Technology; Infrastructure; Laboratories; Maps; Metadata; MicroRNAs; Modeling; Outcome; Pathway interactions; Play; Principal Investigator; Reporting; Research; Research Personnel; Resources; Scientist; Services; Statistical Data Interpretation; System; United States National Institutes of Health; Update; base; bioinformatics resource; biomedical informatics; cancer genomics; comparative genomic hybridization; data integration; data mining; experimental study; forging; improved; mathematical analysis; next generation sequence data; operation; virtual

The CCR Collaborative Bioinformatics Resource (CCBR) is an organizational umbrella which provides a mechanism for CCR researchers to obtain many different types of bioinformatics assistance to further their research goals. This entity pulls together many different bioinformatics expertise within NCI, with strengths in a broad range of bioinformatics topics. The CCBR currently is providing support to over 80 Principal Investigators within CCR and are working on 120 projects related to several different general areas, including support to a wide variety of cancer genomics areas. The newest efforts have been in the area of single-cell genomics. Since its inception in 2011, CCBR has played a progressively key role as an "ecosystem" for bioinformatics support in CCR. This conceptual ecosystem has formed relationships for scientific collaborations and for computational, logistical, and strategic support. This evolving model allows CCBR to strengthen its core service to CCR laboratories while fostering scientific collaborations with other service facilities and embedded bioinformaticians in CCR. The various scientific and operational collaborations create a virtual umbrella under which bioinformatics support is integrated across several logistical pieces of BACS/ABCS operations. These partnerships also act as a conduit for fostering ideas, solutions, and new opportunities.

CCR协作生物信息学资源（CCBR）是一种组织伞，为CCR研究人员提供了一种获得许多不同类型的生物信息学帮助以实现其研究目标的机制。该实体在NCI中汇集了许多不同的生物信息学专业知识，并具有广泛的生物信息学主题。 CCBR目前正在为CCR中的80多名主要研究人员提供支持，并正在研究与几个不同领域有关的120个项目，包括支持各种癌症基因组学领域。最新的努力是在单细胞基因组学领域。自2011年成立以来，CCBR作为CCR中生物信息学支持的“生态系统”逐渐发挥了关键作用。这个概念性生态系统已经建立了科学合作以及计算，后勤和战略支持的关系。这种不断发展的模型使CCBR能够加强其对CCR实验室的核心服务，同时促进与其他服务设施的科学合作，并在CCR中嵌入了生物信息学家。各种科学和运营的合作创建了一个虚拟的伞，在该伞上，生物信息学支持在几个后勤的BAC/ABC操作中集成在一起。这些伙伴关系还充当培养思想，解决方案和新机会的渠道。

项目成果

Micro-environment causes reversible changes in DNA methylation and mRNA expression profiles in patient-derived glioma stem cells.

• DOI: 10.1371/journal.pone.0094045
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Baysan M;Woolard K;Bozdag S;Riddick G;Kotliarova S;Cam MC;Belova GI;Ahn S;Zhang W;Song H;Walling J;Stevenson H;Meltzer P;Fine HA
• 通讯作者: Fine HA

Germline HABP2 Mutation Causing Familial Nonmedullary Thyroid Cancer.

• DOI: 10.1056/nejmoa1502449
• 发表时间: 2015-07-30
• 期刊: The New England journal of medicine
• 作者: Gara SK;Jia L;Merino MJ;Agarwal SK;Zhang L;Cam M;Patel D;Kebebew E
• 通讯作者: Kebebew E

A macrohistone variant links dynamic chromatin compaction to BRCA1-dependent genome maintenance.

• DOI: 10.1016/j.celrep.2014.07.024
• 发表时间: 2014-08-21
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Khurana S;Kruhlak MJ;Kim J;Tran AD;Liu J;Nyswaner K;Shi L;Jailwala P;Sung MH;Hakim O;Oberdoerffer P
• 通讯作者: Oberdoerffer P

Identification of the genomic insertion site of Pmel-1 TCR α and β transgenes by next-generation sequencing.

• DOI: 10.1371/journal.pone.0096650
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Ji Y;Abrams N;Zhu W;Salinas E;Yu Z;Palmer DC;Jailwala P;Franco Z;Roychoudhuri R;Stahlberg E;Gattinoni L;Restifo NP
• 通讯作者: Restifo NP

Genome-wide redistribution of BRD4 binding sites in transformation resistant cells.

转化抗性细胞中 BRD4 结合位点的全基因组重新分布。

• DOI: 10.1016/j.gdata.2014.11.005
• 发表时间: 2015
• 期刊: Genomics data
• 作者: Si,Han;Scaffidi,Paola;Merchant,Anand;Cam,Maggie;Stahlberg,Eric;Misteli,Tom;Fernandez,Patricia
• 通讯作者: Fernandez,Patricia