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Analytical Performance/Clinical Utility Of Laboratory Tests For Atherothrombosis

动脉粥样硬化血栓形成实验室测试的分析性能/临床实用性

基本信息

批准号：
7733631
负责人：
Gyorgy Csako
金额：
$ 2.9万
依托单位：
CLINICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7733631
关键词：
Age Atherosclerosis Bacteria Bacterial Infections Biochemical Pathway Blood Body Weight decreased C-reactive protein CD36 gene Cardiovascular Diseases Cells Cholesterol Clinical Daily Data Diagnosis Disease Employee Endotoxins Exercise Future Glucose Goals Gonadal Steroid Hormones Gram-Negative Bacteria Health Benefit Heart Hemostatic Agents Human Inflammatory Institutes Insulin Laboratories Lipids Lipopolysaccharides Lung Measurable Measures Methods Monitor Morbidity - disease rate Nutritional Obesity Occupations Overweight Oxygen Consumption Performance Play Process Purpose Risk Risk Factors Role Serum Serum amyloid A protein Testing Therapeutic Intervention Woman Work Workplace aged apolipoprotein Lp(a+)atherothrombosis cardiovascular risk factor cell type disorder risk fitness improved lipoprotein triglyceride mortality programs receptor sedentary

项目摘要

Atherothrombosis is a multifactorial disease and risk factors for atherothrombosis are now estimated to be in the hundreds. In addition to classical risk factors like serum lipids (total cholesterol and triglycerides), lipoproteins, and apolipoproteins, a variety of inflammatory molecules such as C-reactive protein and serum amyloid A, hemostatic factors and various specific cell types have been also considered for risk and/or require management. In a collaborative study, we searched for predictors of endothelial function and potential association with cardiovascular risk in women with sedentary occupations, in whom obesity-associated risk factors may contribute to excess morbidity and mortality. Ninety consecutive women (age 22-63 years, 22 overweight and 42 obese) had vital signs and a variety of laboratory parameters (lipids, insulin, glucose, high-sensitivity C-reactive protein, and sex hormones) measured along with assessment of endothelial function. We found that endothelial function was significantly associated with cardiovascular risk in these women with sedentary occupations, who were commonly overweight or obese. Even in the absence of routine exercise, cardiorespiratory fitness, rather than conventional risk factors or body mass, was the dominant predictor of endothelial function and suggested a modifiable approach to risk. In another collaborative study, we investigated predictors of endothelial function in employees with sedentary occupations in a worksite exercise program. Since a sedentary work force may be at increased risk of future cardiovascular disease, our purpose was to determine whether risk could be reduced with nutritional guidance and daily exercise at worksite facilities. Seventy-two sedentary employees (aged 22-62 years; 26 overweight) completed 3 months of participation in the Keep the Beat program of the National Heart, Lung and Blood Institute, with determination of endothelial function, vital signs, laboratory data and peak oxygen consumption during treadmill exercise. Results of this study showed that daily exercise achievable in the workplace, along with nutritional information, have measurable health benefits, including improved endothelial function, regardless of adiposity or weight loss, which may decrease cardiovascular risk, if sustained. In a third collaborative study, we found that a previously described receptor on human cells, CD36, also functions as a phagocytic receptor for a variety of bacteria and hence plays an important role in bacterial infections. Along with identification of a new role for this receptor, we also identified the intracellular biochemical pathways that are activated during interaction of human cells with bacteria. These findings are potentially important for atherosclerosis because it is now considered as an inflammatory disease and toxic components called lipopolysaccharides or endotoxins present in the wall of gram-negative bacteria have been implicated in the atherosclerotic process.

动脉粥样硬化血栓形成是一种多因素疾病，目前估计动脉粥样硬化血栓形成的危险因素有数百个。除了血清脂质（总胆固醇和甘油三酯）、脂蛋白和载脂蛋白等经典危险因素外，C反应蛋白和血清淀粉样蛋白 A 等多种炎症分子、止血因子和各种特定细胞类型也被认为存在风险和/或需要管理。在一项合作研究中，我们寻找了久坐职业女性的内皮功能和与心血管风险的潜在关联的预测因素，其中肥胖相关的危险因素可能导致发病率和死亡率过高。连续 90 名女性（年龄 22-63 岁，22 名超重，42 名肥胖）测量了生命体征和各种实验室参数（血脂、胰岛素、葡萄糖、高敏 C 反应蛋白和性激素）以及内皮功能评估。我们发现，内皮功能与这些久坐职业的女性（通常超重或肥胖）的心血管风险显着相关。即使在缺乏常规锻炼的情况下，心肺健康，而不是传统的危险因素或体重，也是内皮功能的主要预测因素，并提出了一种可修改的风险方法。在另一项合作研究中，我们调查了在工作场所锻炼计划中久坐的员工的内皮功能预测因素。由于久坐的工作人员未来患心血管疾病的风险可能会增加，因此我们的目的是确定是否可以通过工作场所设施的营养指导和日常锻炼来降低风险。 72 名久坐的员工（年龄 22-62 岁；26 名超重）完成了为期 3 个月的国家心肺血液研究所 Keep the Beat 计划的参与，测定了跑步机运动期间的内皮功能、生命体征、实验室数据和峰值耗氧量。这项研究的结果表明，在工作场所进行的日常锻炼以及营养信息具有可衡量的健康益处，包括改善内皮功能，无论肥胖或体重减轻如何，如果持续下去，可能会降低心血管风险。在第三项合作研究中，我们发现先前描述的人类细胞上的受体 CD36 也可作为多种细菌的吞噬细胞受体，因此在细菌感染中发挥重要作用。除了确定该受体的新作用外，我们还确定了在人体细胞与细菌相互作用过程中被激活的细胞内生化途径。这些发现对于动脉粥样硬化可能很重要，因为它现在被认为是一种炎症性疾病，并且革兰氏阴性菌壁中存在的称为脂多糖或内毒素的有毒成分与动脉粥样硬化过程有关。

项目成果

期刊论文数量（29）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Effects of estrogen and the selective estrogen receptor modulator raloxifene on markers of inflammation in postmenopausal women.

雌激素和选择性雌激素受体调节剂雷洛昔芬对绝经后妇女炎症标志物的影响。

DOI：
10.1016/s0002-9149(00)01116-4
发表时间：
2000
期刊：
The American journal of cardiology
影响因子：
0
作者：
Blum,A;Schenke,WH;Hathaway,L;Mincemoyer,R;Csako,G;Waclawiw,MA;Cannon3rd,RO
通讯作者：
Cannon3rd,RO

Effect of hormone replacement therapy on carotid arterial compliance in healthy postmenopausal women.

激素替代疗法对健康绝经后妇女颈动脉顺应性的影响。

DOI：
10.1016/s0002-9149(02)02397-4
发表时间：
2002
期刊：
The American journal of cardiology
影响因子：
0
作者：
Bui,MinhN;Arai,AndrewE;Hathaway,Londa;Waclawiw,MyronA;Csako,Gyorgy;Cannon3rd,RichardO
通讯作者：
Cannon3rd,RichardO

The possible role of hepatitis A virus in the pathogenesis of atherosclerosis.

甲型肝炎病毒在动脉粥样硬化发病机制中的可能作用。