Long-term Follow-up of Cohorts Previously Treated for H. Pylori Infection

对先前接受过幽门螺杆菌感染治疗的队列进行长期随访

• 批准号: 7749277
• 负责人: PELAYO none CORREA
• 金额: $ 16.03万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7749277
• 关键词: Address; Adult; Aftercare; Age; Animal Experiments; Antibiotic Resistance; Antibiotic Therapy; Antibiotics; Ants; Bacteria; Biological; Biological Markers; Biopsy; Cause of Death; Cessation of life; Chemoprevention; Child; Childhood; China; Colombia; Communities; Country; CpG Islands; DNA; Data; Detection; Development; Disease; Eastern Europe; Effectiveness; Endoscopy; Ethics; Evaluation; Feces; Gastric mucosa; Generations; Genes; Genotype; Goals; Helicobacter Infections; Helicobacter pylori; Histopathology; Human Resources; Incidence; Individual; Infection; Instruction; Intervention; Investigation; Japan; Latin America; Lesion; Long-Term Effects; Malignant Neoplasms; Measurement; Methylation; Modeling; Monitor; Neoplasms; Participant; Patients; Pattern; Population; Population Study; Premalignant; Prevalence; Procedures; Process; Randomized; Research Infrastructure; Research Subjects; Residual state; Risk; Risk Factors; Rural Population; Sampling; Screening procedure; Staging; Stomach; Stomach Carcinoma; Surveys; Testing; Time; Tumor Suppressor Genes; Upper arm; Virulence; cancer prevention; cancer risk; carcinogenesis; cohort; cost; effective therapy; follow-up; high risk; instrument; malignant stomach neoplasm; mortality; pathogenic bacteria; post intervention; prevent; programs; resistant strain; tool

While Helicobacter pylori is now established as a pivotal factor in gastric carcinogenesis, its mechanisms of action and timing in the premalignant process are the subject of research. This project builds upon a recently completed 12-year randomized chemoprevention trial in a high-risk region of Colombia. A significantly greater regression of premalignant lesions was observed in study participants who were treated and were cleared of H. pylori infection. Upon completion of the trial, participants who had not been in the ant\-H.pylori treatment arm were offered standard triple therapy. Quarterly contact has been maintained with trial participants, and this project now proposes to evaluate the long-term effectiveness of anti-H.py/or/treatment in an adult population in which the community prevalence of infection is greater than 90%. A cohort of children has been followed-up for 6 years, String tests to culture H. pylori and stool samples to extract DNA are obtained periodically. The specific aims of the study are to: 1. Conduct endoscopy survey, gastric biopsies, and cultures at 18 and 20 years after intervention 2. Test biomarkers of progression of the precancerous process, mainly methylation of CpG islands 3. Genotype Helicobacter pylori at different ages and different stages in the precancerous process RELEVANCE (See instructions): This project provides information of the long term effects of treating patients with antibiotics to cure their infection with the bacterium Helicobacter pylori. The original treatment took place in 1992-1993. How effective the treatment was in preventing cancer development will be investigated.

虽然幽门螺杆菌现已被确定为胃癌发生的关键因素，但其机制 癌前过程中的作用和时机是研究的主题。该项目建立在最近的 在哥伦比亚高风险地区完成了为期 12 年的随机化学预防试验。显着地 在接受治疗并接受治疗的研究参与者中观察到癌前病变有更大的消退。 清除幽门螺杆菌感染。试验完成后，未曾接触过 ant\-H.pylori 的参与者 治疗组接受标准三联疗法。与试验保持季度联系 参与者，该项目现在建议评估抗 H.py/或/治疗的长期有效性 在社区感染率大于 90% 的成年人口中。 对一组儿童进行了 6 年的随访，通过线测试培养幽门螺杆菌，并通过粪便样本进行幽门螺杆菌培养 定期获取提取DNA。 该研究的具体目标是： 1. 干预后18年和20年进行内镜检查、胃活检和培养 2. 检测癌前病变进展的生物标志物，主要是CpG岛的甲基化 3、不同年龄、癌前过程不同阶段的幽门螺杆菌基因型 相关性（参见说明）： 该项目提供了使用抗生素治疗患者的长期效果的信息，以治愈他们的疾病 幽门螺杆菌感染。最初的治疗发生在 1992-1993 年。如何 将调查治疗在预防癌症发展方面的有效性。