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Long-term Follow-up of Cohorts Previously Treated for H. Pylori Infection

对先前接受过幽门螺杆菌感染治疗的队列进行长期随访

基本信息

批准号：
7749277
负责人：
PELAYO none CORREA
金额：
$ 16.03万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-01 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7749277
关键词：
Address Adult Aftercare Age Animal Experiments Antibiotic Resistance Antibiotic Therapy Antibiotics Ants Bacteria Biological Biological Markers Biopsy Cause of Death Cessation of life Chemoprevention Child Childhood China Colombia Communities Country CpG Islands DNA Data Detection Development Disease Eastern Europe Effectiveness Endoscopy Ethics Evaluation Feces Gastric mucosa Generations Genes Genotype Goals Helicobacter Infections Helicobacter pylori Histopathology Human Resources Incidence Individual Infection Instruction Intervention Investigation Japan Latin America Lesion Long-Term Effects Malignant Neoplasms Measurement Methylation Modeling Monitor Neoplasms Participant Patients Pattern Population Population Study Premalignant Prevalence Procedures Process Randomized Research Infrastructure Research Subjects Residual state Risk Risk Factors Rural Population Sampling Screening procedure Staging Stomach Stomach Carcinoma Surveys Testing Time Tumor Suppressor Genes Upper arm Virulence cancer prevention cancer risk carcinogenesis cohort cost effective therapy follow-up high risk instrument malignant stomach neoplasm mortality pathogenic bacteria post intervention prevent programs resistant strain tool

项目摘要

While Helicobacter pylori is now established as a pivotal factor in gastric carcinogenesis, its mechanisms of action and timing in the premalignant process are the subject of research. This project builds upon a recently completed 12-year randomized chemoprevention trial in a high-risk region of Colombia. A significantly greater regression of premalignant lesions was observed in study participants who were treated and were cleared of H. pylori infection. Upon completion of the trial, participants who had not been in the ant\-H.pylori treatment arm were offered standard triple therapy. Quarterly contact has been maintained with trial participants, and this project now proposes to evaluate the long-term effectiveness of anti-H.py/or/treatment in an adult population in which the community prevalence of infection is greater than 90%. A cohort of children has been followed-up for 6 years, String tests to culture H. pylori and stool samples to extract DNA are obtained periodically. The specific aims of the study are to: 1. Conduct endoscopy survey, gastric biopsies, and cultures at 18 and 20 years after intervention 2. Test biomarkers of progression of the precancerous process, mainly methylation of CpG islands 3. Genotype Helicobacter pylori at different ages and different stages in the precancerous process RELEVANCE (See instructions): This project provides information of the long term effects of treating patients with antibiotics to cure their infection with the bacterium Helicobacter pylori. The original treatment took place in 1992-1993. How effective the treatment was in preventing cancer development will be investigated.

虽然目前已确定幽门螺杆菌是胃癌发生的关键因素，但其机制尚不明确