Long-term Follow-up of Cohorts Previously Treated for H. Pylori Infection

对先前接受过幽门螺杆菌感染治疗的队列进行长期随访

• 批准号: 8320333
• 负责人: PELAYO none CORREA
• 金额: $ 15.64万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8320333
• 关键词: Address; Adult; Aftercare; Age; Animal Experiments; Antibiotic Resistance; Antibiotic Therapy; Antibiotics; Ants; Bacteria; Biological; Biological Markers; Biopsy; Cause of Death; Cessation of life; Chemoprevention; Child; Childhood; China; Colombia; Communities; Country; CpG Islands; DNA; Data; Detection; Development; Disease; Eastern Europe; Effectiveness; Endoscopy; Ethics; Evaluation; Feces; Gastric mucosa; Generations; Genes; Genotype; Goals; Helicobacter Infections; Helicobacter pylori; Histopathology; Human Resources; Incidence; Individual; Infection; Instruction; Intervention; Investigation; Japan; Latin America; Lesion; Long-Term Effects; Malignant Neoplasms; Measurement; Methylation; Modeling; Monitor; Neoplasms; Participant; Patients; Pattern; Population; Population Study; Premalignant; Prevalence; Procedures; Process; Randomized; Research Infrastructure; Research Subjects; Residual state; Risk; Risk Factors; Rural Population; Sampling; Screening procedure; Staging; Stomach; Stomach Carcinoma; Surveys; Testing; Time; Tumor Suppressor Genes; Virulence; arm; cancer prevention; cancer risk; carcinogenesis; cohort; cost; effective therapy; follow-up; high risk; instrument; malignant stomach neoplasm; mortality; pathogenic bacteria; post intervention; prevent; programs; resistant strain; tool

While Helicobacter pylori is now established as a pivotal factor in gastric carcinogenesis, its mechanisms of action and timing in the premalignant process are the subject of research. This project builds upon a recently completed 12-year randomized chemoprevention trial in a high-risk region of Colombia. A significantly greater regression of premalignant lesions was observed in study participants who were treated and were cleared of H. pylori infection. Upon completion of the trial, participants who had not been in the ant\-H.pylori treatment arm were offered standard triple therapy. Quarterly contact has been maintained with trial participants, and this project now proposes to evaluate the long-term effectiveness of anti-H.py/or/treatment in an adult population in which the community prevalence of infection is greater than 90%. A cohort of children has been followed-up for 6 years, String tests to culture H. pylori and stool samples to extract DNA are obtained periodically. The specific aims of the study are to: 1. Conduct endoscopy survey, gastric biopsies, and cultures at 18 and 20 years after intervention 2. Test biomarkers of progression of the precancerous process, mainly methylation of CpG islands 3. Genotype Helicobacter pylori at different ages and different stages in the precancerous process RELEVANCE (See instructions): This project provides information of the long term effects of treating patients with antibiotics to cure their infection with the bacterium Helicobacter pylori. The original treatment took place in 1992-1993. How effective the treatment was in preventing cancer development will be investigated.

虽然幽门螺杆菌现在被确定为胃癌发生的关键因素，但其机制 预先辩护过程中的行动和时机是研究的主题。这个项目建立在最近的 在哥伦比亚高危地区完成了12年的随机化学预防试验。一个很大的 在接受治疗的研究参与者中，观察到预先病变的更大回归 清除幽门螺杆菌感染。审判完成后，尚未参加过蚂蚁的参与者 提供治疗组的标准三重治疗。季度联系已通过审判维持 参与者，该项目现在建议评估反h.py/or/theratment的长期有效性 在社区感染率大于90％的成年人口中。 一批儿童已进行了6年的跟踪，对幽门螺杆菌和粪便样本进行了弦测试 定期获得提取DNA。 该研究的具体目的是： 1。干预后18到20年的内窥镜检查，胃活检和培养物 2。癌前过程进展的生物标志物，主要是CpG岛的甲基化 3。在癌前过程中不同年龄和不同阶段的基因型幽门螺杆菌幽门螺杆菌 相关性（请参阅说明）： 该项目提供了治疗抗生素治疗患者的长期影响的信息 细菌幽门螺杆菌感染。最初的治疗发生在1992 - 1993年。如何 有效的治疗方法将在预防癌症的发展中进行研究。