Long-term Follow-up of Cohorts Previously Treated for H. Pylori Infection

对先前接受过幽门螺杆菌感染治疗的队列进行长期随访

• 批准号: 8320333
• 负责人: PELAYO none CORREA
• 金额: $ 15.64万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8320333
• 关键词: Address; Adult; Aftercare; Age; Animal Experiments; Antibiotic Resistance; Antibiotic Therapy; Antibiotics; Ants; Bacteria; Biological; Biological Markers; Biopsy; Cause of Death; Cessation of life; Chemoprevention; Child; Childhood; China; Colombia; Communities; Country; CpG Islands; DNA; Data; Detection; Development; Disease; Eastern Europe; Effectiveness; Endoscopy; Ethics; Evaluation; Feces; Gastric mucosa; Generations; Genes; Genotype; Goals; Helicobacter Infections; Helicobacter pylori; Histopathology; Human Resources; Incidence; Individual; Infection; Instruction; Intervention; Investigation; Japan; Latin America; Lesion; Long-Term Effects; Malignant Neoplasms; Measurement; Methylation; Modeling; Monitor; Neoplasms; Participant; Patients; Pattern; Population; Population Study; Premalignant; Prevalence; Procedures; Process; Randomized; Research Infrastructure; Research Subjects; Residual state; Risk; Risk Factors; Rural Population; Sampling; Screening procedure; Staging; Stomach; Stomach Carcinoma; Surveys; Testing; Time; Tumor Suppressor Genes; Virulence; arm; cancer prevention; cancer risk; carcinogenesis; cohort; cost; effective therapy; follow-up; high risk; instrument; malignant stomach neoplasm; mortality; pathogenic bacteria; post intervention; prevent; programs; resistant strain; tool

While Helicobacter pylori is now established as a pivotal factor in gastric carcinogenesis, its mechanisms of action and timing in the premalignant process are the subject of research. This project builds upon a recently completed 12-year randomized chemoprevention trial in a high-risk region of Colombia. A significantly greater regression of premalignant lesions was observed in study participants who were treated and were cleared of H. pylori infection. Upon completion of the trial, participants who had not been in the ant\-H.pylori treatment arm were offered standard triple therapy. Quarterly contact has been maintained with trial participants, and this project now proposes to evaluate the long-term effectiveness of anti-H.py/or/treatment in an adult population in which the community prevalence of infection is greater than 90%. A cohort of children has been followed-up for 6 years, String tests to culture H. pylori and stool samples to extract DNA are obtained periodically. The specific aims of the study are to: 1. Conduct endoscopy survey, gastric biopsies, and cultures at 18 and 20 years after intervention 2. Test biomarkers of progression of the precancerous process, mainly methylation of CpG islands 3. Genotype Helicobacter pylori at different ages and different stages in the precancerous process RELEVANCE (See instructions): This project provides information of the long term effects of treating patients with antibiotics to cure their infection with the bacterium Helicobacter pylori. The original treatment took place in 1992-1993. How effective the treatment was in preventing cancer development will be investigated.

虽然幽门螺杆菌现在被证实是胃癌发生的关键因素，但它的机制是 癌前过程中的行动和时机是研究的主题。这个项目是建立在最近一个 在哥伦比亚的一个高危地区完成了为期12年的随机化学预防试验。值得注意的是 在接受治疗并接受治疗的研究参与者中观察到癌前病变的更大程度的消退 清除了幽门螺杆菌感染。试验结束后，没有感染过幽门螺杆菌的参与者 治疗组接受标准的三联疗法。每季度通过试用保持联系 参与者，该项目现在建议评估抗H.py/或/治疗的长期效果 在社区感染率超过90%的成年人口中。 对一群儿童进行了6年的随访，进行了幽门螺杆菌培养和粪便样本培养 提取的DNA定期获得。 这项研究的具体目的是： 1.在干预后18年和20年进行内窥镜检查、胃活检和培养 2.检测癌前过程进展的生物标志物，主要是CpG岛的甲基化 3.不同年龄、不同癌前病变阶段幽门螺杆菌的基因分型 相关性(请参阅说明)： 该项目提供了使用抗生素治疗患者的长期效果的信息。 感染幽门螺杆菌。最初的治疗发生在1992-1993年。多么 该疗法在预防癌症发展方面的有效性将得到调查。