10th Annual International Bone Fluid Flow Workshop

第十届国际骨液流动研讨会

• 批准号: 7805173
• 负责人: Henry J Donahue
• 金额: $ 1.5万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-10 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7805173
• 关键词: Address; Aging; Area; Arthritis; Biology; Bone Regeneration; Cells; Clinical Research; Collaborations; Computer Simulation; Computers; Disabled Persons; Disease; Educational workshop; Endothelial Cells; Engineering; Environment; Flow-It; Future; Genomics; Growth and Development function; Image; Imaging Techniques; Individual; Injury; Institutes; International; Joints; Journals; Letters; Medical; Metabolic Bone Diseases; Methodology; Minority; Molecular; Molecular Biology; Musculoskeletal Diseases; Musculoskeletal System; Nature; Orthopedics; Osteoblasts; Osteoclasts; Osteocytes; Osteogenesis Imperfecta; Osteoporosis; Physiological; Probability; Proteomics; Publications; Regenerative Medicine; Research; Research Personnel; Role; Scientist; Source; Stem cells; Stromal Cells; Structure; Techniques; Technology; Tissue Engineering; Tissues; Translations; Woman; Writing; abstracting; bone; bone cell; bone loss; bone metabolism; editorial; fluid flow; instrument; interest; meetings; nano; new therapeutic target; novel therapeutic intervention; programs; skeletal tissue; tissue regeneration; web site

DESCRIPTION (provided by applicant): Abstract Bone fluid flow research has emerged as one of the more exciting research areas in bone. The advent of exciting new molecular technologies including genomics, proteomics and phospho-proteomics present a unique opportunity to better understand the role of fluid flow in bone adaptation. Additionally, advanced imaging techniques and computer modeling methodology promise to reveal the nature of fluid flow within bone with exquisite detail. The quantity of research needed to fully characterize the effects of fluid flow on bone at the nano, micro and macro tissue levels appears vast. However, recent advances in understanding the mechanism by which fluid flow regulates bone metabolism have identified potential new therapeutic targets for treating bone loss to disease, aging or injury. To realize the potential of these new techniques and concepts requires the collaboration of diverse interdisciplinary teams including biologist, engineers, material scientists, computer scientists and clinicians. A perfect opportunity to facilitate these collaborations is the Annual International Bone Fluid Flow (IBFF) Workshop. The objectives of this 10th Annual International Bone Fluid Flow (IBFF) Workshop are to provide an environment that promotes collaborations at the local, national and international level between basic scientists, engineers, material scientists, computer scientists and clinicians in an effort to advance the field of bone fluid flow. This meeting will cover current and potential future directions of bone fluid flow research by discussing each of the following: recent breakthroughs in the fluid flow field, newly developed experimental and imaging approaches that quantify fluid flow through bone, bone cell mechanotransduction and bone fluid flow as it relates to skeletal tissue regeneration. An underlying theme of the meeting will be to address critical issues in physiological mechanisms and translation of these topics to clinical research. We will also make a strong effort to attract, as attendees, young investigators as well as women, minorities and persons with disabilities.

摘要骨液流动研究已成为骨科学中比较令人兴奋的研究领域之一。令人兴奋的新分子技术的出现，包括基因组学、蛋白质组学和磷酸化蛋白质组学，为更好地理解流体在骨适应中的作用提供了一个独特的机会。此外，先进的成像技术和计算机建模方法有望以精美的细节揭示骨内流体流动的本质。为了在纳米、微观和宏观组织水平上充分表征流体流动对骨骼的影响，需要进行大量的研究。然而，最近在了解体液流动调节骨代谢的机制方面取得的进展已经确定了治疗因疾病、衰老或损伤导致的骨质流失的潜在新治疗靶点。为了实现这些新技术和概念的潜力，需要不同跨学科团队的合作，包括生物学家、工程师、材料科学家、计算机科学家和临床医生。年度国际骨液流动（IBFF）研讨会是促进这些合作的一个绝佳机会。第十届国际骨液流动（IBFF）研讨会的目标是提供一个环境，促进地方，国家和国际层面的基础科学家，工程师，材料科学家，计算机科学家和临床医生之间的合作，努力推进骨液流动领域。本次会议将通过讨论以下内容来涵盖当前和潜在的未来骨液流动研究方向：流体流动领域的最新突破，新开发的实验和成像方法，量化通过骨的流体流动，骨细胞机械转导和骨液流动，因为它与骨骼组织再生有关。会议的一个基本主题将是解决生理机制中的关键问题，并将这些问题转化为临床研究。我们还将努力吸引年轻的研究人员以及妇女、少数民族和残疾人作为与会者。