2009 Motile and Contractile Systems Gordon Research Conference

2009 年运动和收缩系统戈登研究会议

• 批准号: 7667081
• 负责人: Kerry S Bloom
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7667081
• 关键词: Actins; Area; Basic Science; Binding; Biological Process; Blindness; Cell Communication; Cell Polarity; Cell division; Cell physiology; Cellular Immunity; Chromosome Segregation; Communities; Complex; Contractile System; Cytoskeleton; Defect; Development; Disease; Elements; Embryonic Development; Eukaryota; Goals; Human; Indium; Infertility; Intracellular Transport; Life; Lung diseases; Membrane; Membrane Protein Traffic; Microtubules; Mind; Molecular; Molecular Motors; Movement; Muscle; Musculoskeletal; Nature; Neurodegenerative Disorders; New Hampshire; Oral; Organism; Physiological; Play; Proteins; Research; Research Personnel; Role; Scientist; Seminal; Signal Transduction; Structure; Students; Vesicle; Work; Wound Healing; abstracting; base; cell growth regulation; cell motility; college; deafness; human disease; insight; interest; lectures; meetings; pathogen; posters; public health relevance; stem; symposium; tumorigenesis

DESCRIPTION (provided by applicant): Support is requested for the 2009 Gordon Research Conference on Motile and Contractile Systems to be held July 12- July 17, 2009 at Colby-Sawyer College in New Hampshire. The purpose of this conference is to encourage the transfer of ideas and information within the community of scientists who work at the forefront of cytoskeletal research, an area that has long been recognized as critical for understanding fundamental biological processes. Cytoskeletal elements are essential for life in eukaryotes, making central contributions to cell motility, cell signaling, membrane trafficking, cell division, cell polarity, and the development of multicellular organisms. Actin, microtubules and molecular motor proteins are important for many normal physiological functions including wound healing, pathogen-cell interactions, cell- mediated immunity and embryogenesis. Moreover, cytoskeletal defects underlie many pathological human conditions including musculoskeletal and neurodegenerative diseases, oncogenesis, respiratory diseases, infertility, congenital blindness, deafness and ciliaopathies. Understanding the molecular basis for these disease states stems directly from basic research discussed at this meeting. The 2009 conference will focus on dynamics of cytoskeletal elements in living cells, and the functions of these complexes in cell locomotion, intracellular transport of membrane-bounded vesicles and mRNAs, chromosome segregation and cell division, and cellular movement within living organism. Because of its breadth and interdisciplinary nature, the Motile and Contractile Systems Gordon Conference has continued to play a seminal role in the field, despite the proliferation of subspecialty meetings. Approximately 60 outstanding research scientists will make formal presentations in eight lecture/discussion sessions. About one-third of these presentations will be selected from the submitted abstracts to encourage participation by outstanding new investigators, postdocs and students. Conferees that do not make oral contributions will be encouraged to present their recent work in a poster format. Public Health Relevance: The cytoskeleton is a complex, dynamic structure that impacts all aspects of cell function including cell division, cell motility, intracellular transport, muscle contractility and regulation of cellular organization. A number of major human diseases have been found to result from alterations in some aspect of cytoskeletal function. It is the goal of the Motile and Contractile Systems GRC to generate new insights into cytoskeletal function and human disease by bringing together a group of diverse and broad-minded scientists interested in basic cellular function.

描述（由申请人提供）：支持要求为2009年戈登研究会议的能动性和收缩系统将于2009年7月12日至7月17日在科尔比索耶学院在新罕布什尔州。本次会议的目的是鼓励在细胞骨架研究前沿工作的科学家社区内转移思想和信息，细胞骨架研究长期以来被认为是理解基本生物过程的关键领域。细胞骨架元素是真核生物生命所必需的，对细胞运动、细胞信号传导、膜运输、细胞分裂、细胞极性和多细胞生物体的发育做出重要贡献。肌动蛋白、微管和分子马达蛋白对于许多正常生理功能包括伤口愈合、病原体-细胞相互作用、细胞介导的免疫和胚胎发生是重要的。此外，细胞骨架缺陷是许多病理性人类病症的基础，包括肌肉骨骼和神经退行性疾病、肿瘤发生、呼吸系统疾病、不育、先天性失明、耳聋和纤毛病。理解这些疾病状态的分子基础直接源于本次会议讨论的基础研究。2009年的会议将集中在活细胞中的细胞骨架元素的动力学，以及这些复合物在细胞运动，膜结合囊泡和mRNA的细胞内运输，染色体分离和细胞分裂，以及活生物体内的细胞运动中的功能。由于其广度和跨学科的性质，运动和收缩系统戈登会议继续在该领域发挥着开创性的作用，尽管亚专业会议的扩散。大约60名杰出的研究科学家将在八个讲座/讨论会上作正式演讲。大约三分之一的演讲将从提交的摘要中选出，以鼓励优秀的新研究人员，博士后和学生的参与。将鼓励不作口头发言的与会者以海报形式介绍其最近的工作。 公共卫生相关性：细胞骨架是一种复杂的动态结构，其影响细胞功能的所有方面，包括细胞分裂、细胞运动、细胞内运输、肌肉收缩性和细胞组织的调节。已经发现许多主要的人类疾病是由细胞骨架功能的某些方面的改变引起的。运动和收缩系统GRC的目标是通过汇集一群对基本细胞功能感兴趣的多元化和广泛的科学家，对细胞骨架功能和人类疾病产生新的见解。