A Compact and Low Cost High-Precision Carbon Isotope Ratio Monitoring Tool for Ro

紧凑、低成本的高精度碳同位素比监测工具

• 批准号: 7802343
• 负责人: Nabil M.R. Saad
• 金额: $ 9.52万
• 依托单位: PICARRO, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-25 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7802343
• 关键词: Compact; Low; Cost; Precision; Carbon

DESCRIPTION (provided by applicant): This application is in response to the FDA's Center for Food Safety and Applied Nutrition (CFSAN) solicitation. One of the pillars of food safety and integrity is labeling that provides a truthful designation of origin and additives in food. Unfortunately, without appropriate authentication and controls in place to ensure the safety and integrity of food, the consumer is at risk of fraud and its sometimes disastrous effects on the health and welfare of the general public. In the USA, the FDA's Center for Food Safety and Applied Nutrition (CFSAN) holds the responsibility of ensuring, predominantly, food safety. However, it is difficult to separate food quality from food safety, as they are interdependent. Isotopic analysis of organic compounds is a critical component of food safety studies and applications. One salient application is the use of stable isotope signature of food constituents as tools for adulteration detection and authenticity confirmation. For food safety applications, 13C variations in organic compounds are the record keepers of the authentic makeup of food item and a proof of its geographic origin. Their isotopic ratio values can be routinely monitored to ensure compliance with regulatory measures and adherence to food label statements. The tool of choice so far for such high-precision measurements are techniques based on continuous-flow Isotope Ratio Mass Spectrometry (IRMS), namely Gas Chromatogrpahy-Combustion-IRMS. Yet, IRMS systems are prohibitively complicated to use and expensive to acquire and operate for them to be widely used as a routine practice in food quality control and authentication studies. Picarro plans to address this opportunity by extending the capabilities of the company's WS-CRDS (wavelength-scanned cavity ring down spectroscopy) instrumentation to develop a fast, simple, and inexpensive replacement for IRMS while meeting or exceeding the performance of Gas Chromatography-Combustion-IRMS (GC-C-IRMS) by coupling a low-cost isotopic CRDS analyzer to a compact Gas Chromatography- Combustion system to measure carbon isotopes of carbon dioxide as the combustion product of individual organic compounds. This effort will advance the state-of-the-art of isotope ratio monitoring instrumentation used to ensure food safety and integrity and will establish routine isotopic monitoring practices by replacing GC-C-IRMS systems with a significantly lower cost GC-C-CRDS system. PUBLIC HEALTH RELEVANCE: One of the pillars of food safety and integrity is food labeling that provides a truthful designation of origin and additives in food products. Unfortunately, without appropriate routine authentication and controls in place to ensure the safety and integrity of food, the consumer is at risk of fraud and its sometimes disastrous effects on the health and welfare of the general public. Picarro plans to address this opportunity by extending the capabilities of the company's wavelength-scanned cavity ring down spectroscopy (WS-CRDS) technology to develop a fast, simple, and inexpensive Gas Chromatography-Combustion-CRDS (GC-C-CRDS) system that will advance the state-of-the-art of isotope ratio monitoring instrumentation to be used for adulteration detection and authenticity confirmation as a routine practice to ensure the safety and integrity of food products.

描述(申请人提供)：此申请是对FDA食品安全和应用营养中心(CFSAN)的邀请的回应。食品安全和完整性的支柱之一是标签，它真实地标明食品中的原产地和添加剂。不幸的是，如果没有适当的认证和控制措施来确保食品的安全和完整性，消费者就会面临欺诈的风险，有时还会对公众的健康和福利造成灾难性的影响。在美国，FDA的食品安全和应用营养中心(CFSAN)主要负责确保食品安全。然而，很难将食品质量与食品安全分开，因为它们是相互依存的。有机化合物的同位素分析是食品安全研究和应用的重要组成部分。一个突出的应用是使用食品成分的稳定同位素签名作为掺假检测和真实性确认的工具。对于食品安全应用，有机化合物中的13C变异是食品正宗组成的记录保持者，也是其地理来源的证据。可以对它们的同位素比值进行常规监测，以确保遵守监管措施和遵守食品标签声明。到目前为止，用于这种高精度测量的工具是基于连续流动同位素比质谱仪(IRMS)的技术，即气相色谱-燃烧-IRMS。然而，IRMS系统的使用复杂得令人望而却步，获得和操作它们的成本也高得令人望而却步，因此它们将被广泛用作食品质量控制和认证研究的常规做法。Picarro计划通过扩展公司的WS-CRDS(波长扫描腔衰荡光谱)仪器的能力来利用这一机会，开发一种快速、简单和廉价的IRMS替代品，同时通过将低成本同位素CRDS分析仪耦合到紧凑型气相色谱-燃烧系统来测量二氧化碳作为单个有机化合物的燃烧产物的碳同位素，同时达到或超过气相色谱-燃烧-IRMS(GC-C-IRMS)的性能。这一努力将推动用于确保食品安全和完整性的同位素比率监测仪器的最先进水平，并将通过用成本低得多的GC-C-CRDS系统取代GC-C-IRMS系统，建立常规的同位素监测做法。 与公众健康相关：食品安全和完整性的支柱之一是食品标签，它真实地标明食品中的原产地和添加剂。不幸的是，如果没有适当的常规认证和控制措施来确保食品的安全和完整性，消费者就会面临欺诈的风险，有时还会对公众的健康和福利造成灾难性的影响。Picarro计划通过扩展公司的波长扫描腔衰荡光谱(WS-CRDS)技术的能力来抓住这一机会，开发一种快速、简单和廉价的气相色谱-燃烧-CRDS(GC-C-CRDS)系统，该系统将推进最先进的同位素比率监测仪器，用于掺假检测和真实性确认，作为确保食品安全和完整性的常规做法。